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C6A168 (RNP1_THESM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein component 1

Short name=RNase P component 1
EC=3.1.26.5
Alternative name(s):
Rpp29
Gene names
Name:rnp1
Ordered Locus Names:TSIB_0297
OrganismThermococcus sibiricus (strain MM 739 / DSM 12597) [Complete proteome] [HAMAP]
Taxonomic identifier604354 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length122 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity. HAMAP-Rule MF_00754

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00754

Subunit structure

Consists of a catalytic RNA component and at least 4-5 protein subunits By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00754.

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmRNA cleavage

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: InterPro

tRNA 5'-leader removal

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonuclease MRP complex

Inferred from electronic annotation. Source: InterPro

ribonuclease P complex

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

ribonuclease P activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 122122Ribonuclease P protein component 1 HAMAP-Rule MF_00754
PRO_1000212852

Sequences

Sequence LengthMass (Da)Tools
C6A168 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 4655CD008EE11E64

FASTA12214,221
        10         20         30         40         50         60 
MWRNSQKWKN RASRRPQRKG EALIDKLWIF RGLDRGRMTK KTLLMHELIG LKVKVVKSSH 

        70         80         90        100        110        120 
PGLIGIEGYV IDETKNTLTI LGTKVWAIPK IVAEFEFEVG DKKIRIKGEE LVGRPEMRLK 


KR 

« Hide

References

[1]"Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MM 739 / DSM 12597.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001463 Genomic DNA. Translation: ACS89363.1.
RefSeqYP_002993712.1. NC_012883.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING604354.TSIB_0297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS89363; ACS89363; TSIB_0297.
GeneID8095270.
KEGGtsi:TSIB_0297.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1588.
HOGENOMHOG000231353.
KOK03538.
OMAISTKGRV.

Enzyme and pathway databases

BioCycTSIB604354:GHMS-303-MONOMER.

Family and domain databases

Gene3D2.30.30.210. 1 hit.
HAMAPMF_00754. RNase_P_1.
InterProIPR002730. RNase_P/MRP_p29.
IPR023538. RNase_P_comp-1.
IPR023534. Rof/RNase_P-like.
[Graphical view]
PfamPF01868. UPF0086. 1 hit.
[Graphical view]
SUPFAMSSF101744. SSF101744. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRNP1_THESM
AccessionPrimary (citable) accession number: C6A168
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: July 9, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families