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C6A0Y7

- PGK_THESM

UniProt

C6A0Y7 - PGK_THESM

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341SubstrateUniRule annotation
Binding sitei114 – 1141SubstrateUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Binding sitei332 – 3321ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi358 – 3614ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSIB604354:GHMS-220-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:TSIB_0215
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000009079: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Phosphoglycerate kinasePRO_1000203351Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi604354.TSIB_0215.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 213Substrate bindingUniRule annotation
Regioni57 – 604Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiAGHPVGK.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Complete.

C6A0Y7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRLSDFNYH DKVIFLRADL NSPVKDGKII SDARFRAVLH TIRYLLEHKA
60 70 80 90 100
KVVIGTHQSK PYEEDYLTTE QHAEILSSLL GVKVKYVDDI FGKCARDAIK
110 120 130 140 150
ALKPSEVLML ENLRFAAEET KQNPLEYCER THFVRKLSPL IDYVVNEAFA
160 170 180 190 200
AAHRSQPSLV GFARIRPMIP GFLMEKEIKA LTRAYESLER PKIYVLGGAK
210 220 230 240 250
VEDSLNVAEN VLRNEKADLI LTGGLVGHVF TLAKGFDLGD ANISFLDEKG
260 270 280 290 300
LIKLVDRAEI ILNEFYPYIR TPVDFAVEYK GERVEIDLLS DKQWIFDERP
310 320 330 340 350
ILDIGSRTIE KYSEILKEAS IIVANGPMGV FEIEEFAKGT VEVFKAIGES
360 370 380 390 400
KAFSIVGGGH SIASIYQYNI KGISHISTGG GAMLTFFAGQ SLPVLQALKI
410
SYEKFKNKKE LNQ
Length:413
Mass (Da):46,459
Last modified:September 1, 2009 - v1
Checksum:i2F4F5348F5F10741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS89282.1.
RefSeqiYP_002993631.1. NC_012883.1.

Genome annotation databases

EnsemblBacteriaiACS89282; ACS89282; TSIB_0215.
GeneIDi8095187.
KEGGitsi:TSIB_0215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS89282.1 .
RefSeqi YP_002993631.1. NC_012883.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 604354.TSIB_0215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS89282 ; ACS89282 ; TSIB_0215 .
GeneIDi 8095187.
KEGGi tsi:TSIB_0215.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi AGHPVGK.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci TSIB604354:GHMS-220-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
    Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
    Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MM 739 / DSM 12597.

Entry informationi

Entry nameiPGK_THESM
AccessioniPrimary (citable) accession number: C6A0Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3