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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (TSIB_0471)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34SubstrateUniRule annotation1
Binding sitei114SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Binding sitei332ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi358 – 361ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSIB604354:G1GV3-210-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:TSIB_0215
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000009079 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002033511 – 413Phosphoglycerate kinaseAdd BLAST413

Proteomic databases

PRIDEiC6A0Y7

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi604354.TSIB_0215

Structurei

3D structure databases

SMRiC6A0Y7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 21Substrate bindingUniRule annotation3
Regioni57 – 60Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00496 Archaea
COG0126 LUCA
HOGENOMiHOG000227108
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG093Z051V

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015824 Phosphoglycerate_kinase_N
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE

Sequencei

Sequence statusi: Complete.

C6A0Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRLSDFNYH DKVIFLRADL NSPVKDGKII SDARFRAVLH TIRYLLEHKA
60 70 80 90 100
KVVIGTHQSK PYEEDYLTTE QHAEILSSLL GVKVKYVDDI FGKCARDAIK
110 120 130 140 150
ALKPSEVLML ENLRFAAEET KQNPLEYCER THFVRKLSPL IDYVVNEAFA
160 170 180 190 200
AAHRSQPSLV GFARIRPMIP GFLMEKEIKA LTRAYESLER PKIYVLGGAK
210 220 230 240 250
VEDSLNVAEN VLRNEKADLI LTGGLVGHVF TLAKGFDLGD ANISFLDEKG
260 270 280 290 300
LIKLVDRAEI ILNEFYPYIR TPVDFAVEYK GERVEIDLLS DKQWIFDERP
310 320 330 340 350
ILDIGSRTIE KYSEILKEAS IIVANGPMGV FEIEEFAKGT VEVFKAIGES
360 370 380 390 400
KAFSIVGGGH SIASIYQYNI KGISHISTGG GAMLTFFAGQ SLPVLQALKI
410
SYEKFKNKKE LNQ
Length:413
Mass (Da):46,459
Last modified:September 1, 2009 - v1
Checksum:i2F4F5348F5F10741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA Translation: ACS89282.1
RefSeqiWP_012766243.1, NC_012883.1

Genome annotation databases

EnsemblBacteriaiACS89282; ACS89282; TSIB_0215
GeneIDi8095187
KEGGitsi:TSIB_0215

Similar proteinsi

Entry informationi

Entry nameiPGK_THESM
AccessioniPrimary (citable) accession number: C6A0Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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