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Protein

Probable thymidylate kinase

Gene

tmk

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSIB604354:G1GV3-147-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:TSIB_0148
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000009079 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002036311 – 210Probable thymidylate kinaseAdd BLAST210

Proteomic databases

PRIDEiC6A0S1

Interactioni

Protein-protein interaction databases

STRINGi604354.TSIB_0148

Structurei

3D structure databases

SMRiC6A0S1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01891 Archaea
COG0125 LUCA
HOGENOMiHOG000229077
KOiK00943
OMAiFLYTADH
OrthoDBiPOG093Z0A1C

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

C6A0S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIFIVLEGI DGAGKSTQAK MLAKWFENRG YEVVLTKEPT DTAFGKLIRR
60 70 80 90 100
LVLIGGKEGI IDGARISKEA EALLFAADRA EHVKKLIEPS IKAGKVVISD
110 120 130 140 150
RYFYSSLAYQ WARGLDLNWL INLNAFAPRA DLVILLDLPV KESINRINGR
160 170 180 190 200
SIRSEFDKIV ELQKKVRKNY LKLAEKFNEI RIINALAPVE DIHNDITALI
210
EHELFEKAED
Length:210
Mass (Da):23,734
Last modified:September 1, 2009 - v1
Checksum:iECCC43F989EA94F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA Translation: ACS89216.1
RefSeqiWP_012766177.1, NC_012883.1

Genome annotation databases

EnsemblBacteriaiACS89216; ACS89216; TSIB_0148
GeneIDi8095120
KEGGitsi:TSIB_0148

Similar proteinsi

Entry informationi

Entry nameiKTHY_THESM
AccessioniPrimary (citable) accession number: C6A0S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health