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C5ZZZ3

- SYR_THESM

UniProt

C5ZZZ3 - SYR_THESM

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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSIB604354:GHMS-1970-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:TSIB_1925
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000009079: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Arginine--tRNA ligasePRO_1000203108Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi604354.TSIB_1925.

Structurei

3D structure databases

ProteinModelPortaliC5ZZZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 14411"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247213.
KOiK01887.
OMAiMEHMGFG.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5ZZZ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTYDDIKAKV GELLKTIISE MLEKEGKTWE GEILFDETPN MEFGDFATTV
60 70 80 90 100
AFLLAKVFKK APRIIAQEIA SNLEDKLPEY IAKVEVAGAG YINFFLDYEK
110 120 130 140 150
FSKLTVKEIL QKGEHFGESK IGEGKKVIVE HTSVNPTKPL HMGHARNAVL
160 170 180 190 200
GDTVARIMRA LGYNVEVQNY IDDLGVQFAQ VLWGYLNMRE EFESIIKELK
210 220 230 240 250
EKGLSKEDIL DHALGLLYVE VHKKMEEYPE VEREIRSIMK ELEKEDNEIS
260 270 280 290 300
EKGRKLAEDV VKAQMKTTYR LSISYDLLSW ESDIVRSGIF EESYKRIQEN
310 320 330 340 350
SHFEWAQEGK YKGAFIMKLG DLFPDLENPD TVLIRSDGTA TYTGKDIAYH
360 370 380 390 400
LWKFGKVSAD MRYKVWDKIN DHKTWTTAKD GERMPGRFAN AEIVINVVGS
410 420 430 440 450
EQRYEQMAVA YALKLLGYEE EYHNFHHLAY EHVVRPEGKF SGRKGTWIGF
460 470 480 490 500
TVDEVLDEAV KRAKELVEEK NPSLSGEEKE KIAEIVGVGA VRYNLVKYSP
510 520 530 540 550
EKIITFRWED VLNFEGESAP YIQYAHARCA SILKKAMEEG INIDKDALLK
560 570 580 590 600
NADFSKLDNK EKELIKIISK FPEIVKTAGR DIKPHLLATY ANELAMVFNS
610 620 630 640
FYMALPVLKA EEGVRELRLL LVIATKQVLK NTLGLMGIEA PEVM
Length:644
Mass (Da):73,624
Last modified:September 1, 2009 - v1
Checksum:i2AEBBCFC4ED85354
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001463 Genomic DNA. Translation: ACS90974.1.
RefSeqiYP_002995323.1. NC_012883.1.

Genome annotation databases

EnsemblBacteriaiACS90974; ACS90974; TSIB_1925.
GeneIDi8096937.
KEGGitsi:TSIB_1925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001463 Genomic DNA. Translation: ACS90974.1 .
RefSeqi YP_002995323.1. NC_012883.1.

3D structure databases

ProteinModelPortali C5ZZZ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 604354.TSIB_1925.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS90974 ; ACS90974 ; TSIB_1925 .
GeneIDi 8096937.
KEGGi tsi:TSIB_1925.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247213.
KOi K01887.
OMAi MEHMGFG.

Enzyme and pathway databases

BioCyci TSIB604354:GHMS-1970-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
    Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
    Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MM 739 / DSM 12597.

Entry informationi

Entry nameiSYR_THESM
AccessioniPrimary (citable) accession number: C5ZZZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3