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C5ZZZ3 (SYR_THESM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:TSIB_1925
OrganismThermococcus sibiricus (strain MM 739 / DSM 12597) [Complete proteome] [HAMAP]
Taxonomic identifier604354 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length644 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 644644Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000203108

Regions

Motif134 – 14411"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
C5ZZZ3 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 2AEBBCFC4ED85354

FASTA64473,624
        10         20         30         40         50         60 
MTYDDIKAKV GELLKTIISE MLEKEGKTWE GEILFDETPN MEFGDFATTV AFLLAKVFKK 

        70         80         90        100        110        120 
APRIIAQEIA SNLEDKLPEY IAKVEVAGAG YINFFLDYEK FSKLTVKEIL QKGEHFGESK 

       130        140        150        160        170        180 
IGEGKKVIVE HTSVNPTKPL HMGHARNAVL GDTVARIMRA LGYNVEVQNY IDDLGVQFAQ 

       190        200        210        220        230        240 
VLWGYLNMRE EFESIIKELK EKGLSKEDIL DHALGLLYVE VHKKMEEYPE VEREIRSIMK 

       250        260        270        280        290        300 
ELEKEDNEIS EKGRKLAEDV VKAQMKTTYR LSISYDLLSW ESDIVRSGIF EESYKRIQEN 

       310        320        330        340        350        360 
SHFEWAQEGK YKGAFIMKLG DLFPDLENPD TVLIRSDGTA TYTGKDIAYH LWKFGKVSAD 

       370        380        390        400        410        420 
MRYKVWDKIN DHKTWTTAKD GERMPGRFAN AEIVINVVGS EQRYEQMAVA YALKLLGYEE 

       430        440        450        460        470        480 
EYHNFHHLAY EHVVRPEGKF SGRKGTWIGF TVDEVLDEAV KRAKELVEEK NPSLSGEEKE 

       490        500        510        520        530        540 
KIAEIVGVGA VRYNLVKYSP EKIITFRWED VLNFEGESAP YIQYAHARCA SILKKAMEEG 

       550        560        570        580        590        600 
INIDKDALLK NADFSKLDNK EKELIKIISK FPEIVKTAGR DIKPHLLATY ANELAMVFNS 

       610        620        630        640 
FYMALPVLKA EEGVRELRLL LVIATKQVLK NTLGLMGIEA PEVM 

« Hide

References

[1]"Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MM 739 / DSM 12597.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001463 Genomic DNA. Translation: ACS90974.1.
RefSeqYP_002995323.1. NC_012883.1.

3D structure databases

ProteinModelPortalC5ZZZ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING604354.TSIB_1925.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS90974; ACS90974; TSIB_1925.
GeneID8096937.
KEGGtsi:TSIB_1925.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMAMEHMGFG.

Enzyme and pathway databases

BioCycTSIB604354:GHMS-1970-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_THESM
AccessionPrimary (citable) accession number: C5ZZZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries