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Protein

E3 ubiquitin-protein ligase

Gene

SORBI_3009G047900

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.UniRule annotation

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathwayUniRule annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligaseUniRule annotation (EC:2.3.2.27UniRule annotation)
Gene namesi
ORF Names:SORBI_3009G047900Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeSorghinaeSorghum
Proteomesi
  • UP000000768 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb09g004110.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 220RING-typeInterPro annotationAdd BLAST39
Domaini239 – 298SIAH-typeInterPro annotationAdd BLAST60

Domaini

The RING-type zinc finger domain is essential for ubiquitin ligase activity.UniRule annotation
The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.UniRule annotation

Sequence similaritiesi

Belongs to the SINA (Seven in absentia) family.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3002. Eukaryota.
ENOG410XVP0. LUCA.
InParanoidiC5Z074.
OrthoDBiEOG09360HR5.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR018121. 7-in-absentia-prot_TRAF-dom.
IPR004162. SINA-like.
IPR008974. TRAF-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR013010. Znf_SIAH.
PANTHERiPTHR10315. PTHR10315. 1 hit.
PfamiView protein in Pfam
PF03145. Sina. 1 hit.
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.
PS51081. ZF_SIAH. 1 hit.

Sequencei

Sequence statusi: Complete.

C5Z074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVRRPILY SSQRRWRTWS SVAERGESSL SRKRARSRPP PPRLPLRYYY
60 70 80 90 100
SDDVVVDDGS HGRSHDDDYG EEEEDEEQIR TEDDRYPSRG NVSSGADDAA
110 120 130 140 150
EAGGAVEEQL PPEDEDSGDD DRPLSSVVAR AHTLVHRRSI STAPASMPAP
160 170 180 190 200
APPESSPTSS SSSDSSSVIK NVTVENSSAF DCSICYLPLK SPIFQCPVGH
210 220 230 240 250
VVCSPCHDKL RQATNCHVCR VPIPGGYFRC NAMEKVVDSI RVPCPHAAHG
260 270 280 290 300
CAERMAYHDR DGHARTCAHK PCHCPGEGCG FSGSVQTTLL EHFAAVHGWP
310 320 330 340 350
CSAGTATGMS GFVVSLRKGF NVVVVTAGAD DCGTTTTTTE QQYTLVLNVE
360 370 380 390 400
QAAPVCNTIT AFCIHPSHTG TVTVRLSYYR WYRWWRLDSD CCHRRQYAQS
410 420 430 440
SQLDVVCTDL SNGMPGPSSC FPLLVPRWSS PGGEDDEDIR VTVNYIRGN
Length:449
Mass (Da):49,157
Last modified:September 1, 2009 - v1
Checksum:iB63BC680784A96AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000768 Genomic DNA. Translation: EES17735.1.
RefSeqiXP_002439305.1. XM_002439260.1.

Genome annotation databases

EnsemblPlantsiEES17735; EES17735; SORBI_009G047900.
GrameneiEES17735; EES17735; SORBI_009G047900.

Entry informationi

Entry nameiC5Z074_SORBI
AccessioniPrimary (citable) accession number: C5Z074
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: January 31, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported