ID   C5YKQ5_SORBI            Unreviewed;      1260 AA.
AC   C5YKQ5;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 88.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SORBI_3007G121700 {ECO:0000313|EMBL:EES13798.1};
OS   Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX   NCBI_TaxID=4558 {ECO:0000313|EMBL:EES13798.1, ECO:0000313|Proteomes:UP000000768};
RN   [1] {ECO:0000313|EMBL:EES13798.1, ECO:0000313|Proteomes:UP000000768}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX   PubMed=19189423; DOI=10.1038/nature07723;
RA   Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA   Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA   Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA   Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA   Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA   Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA   Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA   Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT   "The Sorghum bicolor genome and the diversification of grasses.";
RL   Nature 457:551-556(2009).
RN   [2] {ECO:0000313|Proteomes:UP000000768}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX   PubMed=29161754; DOI=10.1111/tpj.13781;
RA   McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA   Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA   Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT   "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT   a transcriptome atlas, and signatures of genome organization.";
RL   Plant J. 93:338-354(2018).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00358}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM000766; EES13798.1; -; Genomic_DNA.
DR   RefSeq; XP_002444303.1; XM_002444258.1.
DR   AlphaFoldDB; C5YKQ5; -.
DR   STRING; 4558.C5YKQ5; -.
DR   EnsemblPlants; EES13798; EES13798; SORBI_3007G121700.
DR   GeneID; 8070040; -.
DR   Gramene; EES13798; EES13798; SORBI_3007G121700.
DR   KEGG; sbi:8070040; -.
DR   eggNOG; KOG1082; Eukaryota.
DR   HOGENOM; CLU_004556_1_0_1; -.
DR   InParanoid; C5YKQ5; -.
DR   OMA; HIAKYQN; -.
DR   OrthoDB; 5481936at2759; -.
DR   Proteomes; UP000000768; Chromosome 7.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0042054; F:histone methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   Gene3D; 2.30.280.10; SRA-YDG; 1.
DR   InterPro; IPR025794; H3-K9-MeTrfase_plant.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR036987; SRA-YDG_sf.
DR   InterPro; IPR003105; SRA_YDG.
DR   PANTHER; PTHR45660; HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR; 1.
DR   PANTHER; PTHR45660:SF11; OS08G0400200 PROTEIN; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF02182; SAD_SRA; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00466; SRA; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS51575; SAM_MT43_SUVAR39_2; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS51015; YDG; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00358}; Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          802..953
FT                   /note="YDG"
FT                   /evidence="ECO:0000259|PROSITE:PS51015"
FT   DOMAIN          1023..1083
FT                   /note="Pre-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50867"
FT   DOMAIN          1086..1230
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          1244..1260
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1260 AA;  135107 MW;  B3BA5071A06E30E5 CRC64;
     MDSYAARLDV ARQPRLPVPG PAAGRVGRAC PPQRADHRGR PPASPRGCGG DTRRAGGLRE
     HGVVAAAVAA TAIAAGSVGD DAAAGVAAAM VAREETGGSE VGSKRCLPLA AAHPPPKRRA
     VSARRRFPPQ CGRNVAAPLA TANNASRFGD AGAEVCSAVL DLEKTAASSP LAGGKDGALL
     GAVSPVSAAT SLVKQLCAVD GDAPMADGGH HGPQPGVVKS SEALRRSGGT AVDGLLDGGS
     QGVAAVSMED RGKGAWSGEL GRKELVPDAH LQANPRMSLD ERSFPLGYGK DAVLSLLLAG
     GSSKVCLPLK SRPTDKLGVL EEAVVATHGC ISSVQGHYIK IVSNDGTVQD YELEDGEIPP
     ELVVQESQVS TGVALHESTD CRHGPSVPEV NAKETFAMQP CNEKTGGDTL QCGEKISSYL
     VANDVEVVNK SIGSSVNVVA ASLAEDLSKQ NMVGKRVSES AMMNIVDVTA GGCGNGTTMR
     CVTMHDSAAC RHGDSVPEIS AVETSVMQSS NEKTGGNILQ CGDKKSSCLV TKDIEVMNKS
     IRISCTAVAG PLAEDSFKQN LMGKRVSESA RMNRASDDVA AATSGNSIMM RSKVRFTPRK
     VIKLSKVIQK STLDTRHRHC PEDREKETEL SRRGIINKIE DTDKLTKDRV LQAPMTQEKE
     AATTRGFFGP RKRVKVKVPA HLQMKIASTC ALGCKVKLDD KVASSLDDDD ILKALVVNEG
     NLELFLNSYS SLTSARCQMK HGSQNADARS KFKMLCRRFE FVCRALVQAV EQNSLKIRRI
     DLQADRVIRK LPGFTKSGPI VGQVPGVQVG DEFLYRVQLA IVGLHLAYQG GIDTTIYRNG
     ERIAISIVAS GGYPDELSSS GELIYSGSGG KPAGKKDHED QKLERGNLAL KNCIKTKTPV
     RVIYGFKAQN NRVGSHSRAR EVSTFTYDGL YRVLDFWMDG QPGSRVFKYK LKKIPGQPKL
     PMHMAEGMRK SKTRPGLCEI DISQGKEGIP ICVINTVDTE RPAPFRYTTR IRYPFELTKK
     RHQGCDCTNG CSDSVSCACA VKNGGEIPFN LNGAIVNEKP LIFECGPSCK CPPSCQNKVS
     QHGLKIPLEV FKTTKTGWGV RSLRSISSGS FICEYVGELL YGNEADERRN SNFLFDIGLN
     HGDENFCNGL LSDVSDMKSS SSSSQILGDV GFTIDSAECG NIGRFINHSC SPNLYAQNVL
     WDHDDLRIPH IMFFAAETIP PLQELTYDYN YEIDHVEDVN GRIKFKVCQC GSSGCSGRLY
//