Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C5YBX0

- C5YBX0_SORBI

UniProt

C5YBX0 - C5YBX0_SORBI

Protein

Isocitrate dehydrogenase [NADP]

Gene

Sb06g022050

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei152 – 1521Substrate
    Binding sitei157 – 1571NADPUniRule annotation
    Binding sitei184 – 1841Substrate
    Binding sitei207 – 2071SubstrateUniRule annotation
    Sitei214 – 2141Critical for catalysisUniRule annotation
    Sitei285 – 2851Critical for catalysisUniRule annotation
    Metal bindingi325 – 3251Magnesium or manganeseUniRule annotation
    Binding sitei333 – 3331NADPUniRule annotation
    Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
    Binding sitei401 – 4011NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi150 – 1523NADPUniRule annotation
    Nucleotide bindingi383 – 3886NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:Sb06g022050Imported
    ORF Names:SORBIDRAFT_06g022050Imported
    OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
    Taxonomic identifieri4558 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum
    ProteomesiUP000000768: Chromosome 6

    Organism-specific databases

    GrameneiC5YBX0.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast stroma Source: EnsemblPlants/Gramene
    2. chloroplast thylakoid Source: EnsemblPlants/Gramene

    Interactioni

    Protein-protein interaction databases

    STRINGi4558.Sb06g022050.1.

    Structurei

    3D structure databases

    ProteinModelPortaliC5YBX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni169 – 1757Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5YBX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNLLLPRRL LSAPTMARAS VSGSAAAAKA LLPLNPVRGG RLPSLLPARL    50
    PVPGSARVLR GASLRCYAAA AAVAEQSRIK VQNPIVEMDG DEMTRVIWKL 100
    IKDKLIFPYL ELDVKYYDLG ILNRDATNDE VTVESAEATL KYNVAVKCAT 150
    ITPDETRVKE FKLKSMWRSP NGTIRNILNG TVFREPILCK NIPRILSGWK 200
    KPICIGRHAF GDQYRATDMI INGPGKLKMV FVPDGADPME LDVYDFKGPG 250
    VALSMYNVDE SIRAFAESSM AMALSKKWPL YLSTKNTILK KYDGRFKDIF 300
    QEVYEEQWKE KFEANSIWYE HRLIDDMVAY AVKSDGGYVW ACKNYDGDVQ 350
    SDFLAQGFGS LGLMTSVLLS SDGKTLEAEA AHGTVTRHFR LHQKGQETST 400
    NSIASIFAWT RGLEHRAKLD KNDSLLDFTH KLESACVETV ESGKMTKDLA 450
    LLIHGPKVTR EFYLSTEEFI DAVAQQLRGK IQLPTMV 487
    Length:487
    Mass (Da):54,412
    Last modified:September 1, 2009 - v1
    Checksum:iE3C9F8AE5EB5A896
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000765 Genomic DNA. Translation: EES11093.1.
    RefSeqiXP_002446765.1. XM_002446720.1.
    UniGeneiSbi.5433.

    Genome annotation databases

    EnsemblPlantsiSb06g022050.1; Sb06g022050.1; Sb06g022050.
    GeneIDi8075909.
    KEGGisbi:SORBI_06g022050.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000765 Genomic DNA. Translation: EES11093.1 .
    RefSeqi XP_002446765.1. XM_002446720.1.
    UniGenei Sbi.5433.

    3D structure databases

    ProteinModelPortali C5YBX0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4558.Sb06g022050.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi Sb06g022050.1 ; Sb06g022050.1 ; Sb06g022050 .
    GeneIDi 8075909.
    KEGGi sbi:SORBI_06g022050.

    Organism-specific databases

    Gramenei C5YBX0.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. BTx623Imported.

    Entry informationi

    Entry nameiC5YBX0_SORBI
    AccessioniPrimary (citable) accession number: C5YBX0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3