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C5YBX0

- C5YBX0_SORBI

UniProt

C5YBX0 - C5YBX0_SORBI

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Sb06g022050, SORBIDRAFT_06g022050
Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521Substrate By similarityUniRule annotation
Binding sitei157 – 1571NADP By similarity
Binding sitei184 – 1841Substrate By similarityUniRule annotation
Binding sitei207 – 2071Substrate By similarityUniRule annotation
Sitei214 – 2141Critical for catalysis By similarityUniRule annotation
Sitei285 – 2851Critical for catalysis By similarityUniRule annotation
Metal bindingi325 – 3251Magnesium or manganese By similarityUniRule annotation
Binding sitei333 – 3331NADP By similarity
Metal bindingi348 – 3481Magnesium or manganese By similarityUniRule annotation
Binding sitei401 – 4011NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1523NADP By similarity
Nucleotide bindingi383 – 3886NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:Sb06g022050Imported
ORF Names:SORBIDRAFT_06g022050Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum
ProteomesiUP000000768: Chromosome 6

Organism-specific databases

GrameneiC5YBX0.

Subcellular locationi

GO - Cellular componenti

  1. chloroplast stroma Source: EnsemblPlants/Gramene
  2. chloroplast thylakoid Source: EnsemblPlants/Gramene
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb06g022050.1.

Structurei

3D structure databases

ProteinModelPortaliC5YBX0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni169 – 1757Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5YBX0-1 [UniParc]FASTAAdd to Basket

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MRNLLLPRRL LSAPTMARAS VSGSAAAAKA LLPLNPVRGG RLPSLLPARL    50
PVPGSARVLR GASLRCYAAA AAVAEQSRIK VQNPIVEMDG DEMTRVIWKL 100
IKDKLIFPYL ELDVKYYDLG ILNRDATNDE VTVESAEATL KYNVAVKCAT 150
ITPDETRVKE FKLKSMWRSP NGTIRNILNG TVFREPILCK NIPRILSGWK 200
KPICIGRHAF GDQYRATDMI INGPGKLKMV FVPDGADPME LDVYDFKGPG 250
VALSMYNVDE SIRAFAESSM AMALSKKWPL YLSTKNTILK KYDGRFKDIF 300
QEVYEEQWKE KFEANSIWYE HRLIDDMVAY AVKSDGGYVW ACKNYDGDVQ 350
SDFLAQGFGS LGLMTSVLLS SDGKTLEAEA AHGTVTRHFR LHQKGQETST 400
NSIASIFAWT RGLEHRAKLD KNDSLLDFTH KLESACVETV ESGKMTKDLA 450
LLIHGPKVTR EFYLSTEEFI DAVAQQLRGK IQLPTMV 487
Length:487
Mass (Da):54,412
Last modified:September 1, 2009 - v1
Checksum:iE3C9F8AE5EB5A896
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000765 Genomic DNA. Translation: EES11093.1.
RefSeqiXP_002446765.1. XM_002446720.1.
UniGeneiSbi.5433.

Genome annotation databases

EnsemblPlantsiSb06g022050.1; Sb06g022050.1; Sb06g022050.
GeneIDi8075909.
KEGGisbi:SORBI_06g022050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000765 Genomic DNA. Translation: EES11093.1 .
RefSeqi XP_002446765.1. XM_002446720.1.
UniGenei Sbi.5433.

3D structure databases

ProteinModelPortali C5YBX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4558.Sb06g022050.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi Sb06g022050.1 ; Sb06g022050.1 ; Sb06g022050 .
GeneIDi 8075909.
KEGGi sbi:SORBI_06g022050.

Organism-specific databases

Gramenei C5YBX0.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. BTx623.

Entry informationi

Entry nameiC5YBX0_SORBI
AccessioniPrimary (citable) accession number: C5YBX0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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