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C5YBX0 (C5YBX0_SORBI) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:Sb06g022050 EMBL EES11093.1
ORF Names:SORBIDRAFT_06g022050 EMBL EES11093.1
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare) [Reference proteome]
Taxonomic identifier4558 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding150 – 1523NADP By similarity
Nucleotide binding383 – 3886NADP By similarity
Region169 – 1757Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding3251Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding3481Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site1521Substrate By similarity PIRSR PIRSR000108-2
Binding site1571NADP By similarity
Binding site1841Substrate By similarity PIRSR PIRSR000108-2
Binding site2071Substrate By similarity PIRSR PIRSR000108-2
Binding site3331NADP By similarity
Binding site4011NADP; via amide nitrogen and carbonyl oxygen By similarity
Site2141Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2851Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
C5YBX0 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: E3C9F8AE5EB5A896

FASTA48754,412
        10         20         30         40         50         60 
MRNLLLPRRL LSAPTMARAS VSGSAAAAKA LLPLNPVRGG RLPSLLPARL PVPGSARVLR 

        70         80         90        100        110        120 
GASLRCYAAA AAVAEQSRIK VQNPIVEMDG DEMTRVIWKL IKDKLIFPYL ELDVKYYDLG 

       130        140        150        160        170        180 
ILNRDATNDE VTVESAEATL KYNVAVKCAT ITPDETRVKE FKLKSMWRSP NGTIRNILNG 

       190        200        210        220        230        240 
TVFREPILCK NIPRILSGWK KPICIGRHAF GDQYRATDMI INGPGKLKMV FVPDGADPME 

       250        260        270        280        290        300 
LDVYDFKGPG VALSMYNVDE SIRAFAESSM AMALSKKWPL YLSTKNTILK KYDGRFKDIF 

       310        320        330        340        350        360 
QEVYEEQWKE KFEANSIWYE HRLIDDMVAY AVKSDGGYVW ACKNYDGDVQ SDFLAQGFGS 

       370        380        390        400        410        420 
LGLMTSVLLS SDGKTLEAEA AHGTVTRHFR LHQKGQETST NSIASIFAWT RGLEHRAKLD 

       430        440        450        460        470        480 
KNDSLLDFTH KLESACVETV ESGKMTKDLA LLIHGPKVTR EFYLSTEEFI DAVAQQLRGK 


IQLPTMV 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000765 Genomic DNA. Translation: EES11093.1.
RefSeqXP_002446765.1. XM_002446720.1.
UniGeneSbi.5433.

3D structure databases

ProteinModelPortalC5YBX0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4558.Sb06g022050.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsSb06g022050.1; Sb06g022050.1; Sb06g022050.
GeneID8075909.
KEGGsbi:SORBI_06g022050.

Organism-specific databases

GrameneC5YBX0.

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC5YBX0_SORBI
AccessionPrimary (citable) accession number: C5YBX0
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)