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Protein

Isocitrate dehydrogenase [NADP]

Gene

Sb06g022050

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521SubstrateUniRule annotation
Binding sitei157 – 1571NADPUniRule annotation
Binding sitei184 – 1841SubstrateUniRule annotation
Binding sitei207 – 2071SubstrateUniRule annotation
Sitei214 – 2141Critical for catalysisUniRule annotation
Sitei285 – 2851Critical for catalysisUniRule annotation
Metal bindingi325 – 3251Magnesium or manganeseUniRule annotation
Binding sitei333 – 3331NADPUniRule annotation
Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
Binding sitei401 – 4011NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1523NADPUniRule annotation
Nucleotide bindingi383 – 3886NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: EnsemblPlants/Gramene
  3. NAD binding Source: EnsemblPlants/Gramene

GO - Biological processi

  1. isocitrate metabolic process Source: EnsemblPlants/Gramene
  2. response to stress Source: EnsemblPlants/Gramene
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:Sb06g022050Imported
ORF Names:SORBIDRAFT_06g022050Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum
ProteomesiUP000000768 Componenti: Chromosome 6

Organism-specific databases

GrameneiC5YBX0.

Subcellular locationi

GO - Cellular componenti

  1. chloroplast stroma Source: EnsemblPlants/Gramene
  2. chloroplast thylakoid Source: EnsemblPlants/Gramene
  3. mitochondrion Source: EnsemblPlants/Gramene
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb06g022050.1.

Structurei

3D structure databases

ProteinModelPortaliC5YBX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni169 – 1757Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
InParanoidiC5YBX0.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5YBX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNLLLPRRL LSAPTMARAS VSGSAAAAKA LLPLNPVRGG RLPSLLPARL
60 70 80 90 100
PVPGSARVLR GASLRCYAAA AAVAEQSRIK VQNPIVEMDG DEMTRVIWKL
110 120 130 140 150
IKDKLIFPYL ELDVKYYDLG ILNRDATNDE VTVESAEATL KYNVAVKCAT
160 170 180 190 200
ITPDETRVKE FKLKSMWRSP NGTIRNILNG TVFREPILCK NIPRILSGWK
210 220 230 240 250
KPICIGRHAF GDQYRATDMI INGPGKLKMV FVPDGADPME LDVYDFKGPG
260 270 280 290 300
VALSMYNVDE SIRAFAESSM AMALSKKWPL YLSTKNTILK KYDGRFKDIF
310 320 330 340 350
QEVYEEQWKE KFEANSIWYE HRLIDDMVAY AVKSDGGYVW ACKNYDGDVQ
360 370 380 390 400
SDFLAQGFGS LGLMTSVLLS SDGKTLEAEA AHGTVTRHFR LHQKGQETST
410 420 430 440 450
NSIASIFAWT RGLEHRAKLD KNDSLLDFTH KLESACVETV ESGKMTKDLA
460 470 480
LLIHGPKVTR EFYLSTEEFI DAVAQQLRGK IQLPTMV
Length:487
Mass (Da):54,412
Last modified:September 1, 2009 - v1
Checksum:iE3C9F8AE5EB5A896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000765 Genomic DNA. Translation: EES11093.1.
RefSeqiXP_002446765.1. XM_002446720.1.
UniGeneiSbi.5433.

Genome annotation databases

EnsemblPlantsiSb06g022050.1; Sb06g022050.1; Sb06g022050.
GeneIDi8075909.
KEGGisbi:SORBI_06g022050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000765 Genomic DNA. Translation: EES11093.1.
RefSeqiXP_002446765.1. XM_002446720.1.
UniGeneiSbi.5433.

3D structure databases

ProteinModelPortaliC5YBX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4558.Sb06g022050.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSb06g022050.1; Sb06g022050.1; Sb06g022050.
GeneIDi8075909.
KEGGisbi:SORBI_06g022050.

Organism-specific databases

GrameneiC5YBX0.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
InParanoidiC5YBX0.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. BTx623Imported.

Entry informationi

Entry nameiC5YBX0_SORBI
AccessioniPrimary (citable) accession number: C5YBX0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: February 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.