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Protein

Elongator complex protein 3

Gene

SORBI_006G125900

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.UniRule annotation

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandIron, Iron-sulfurUniRule annotation, Metal-binding, S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3UniRule annotation (EC:2.3.1.48UniRule annotation)
Gene namesi
ORF Names:SORBI_006G125900Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeSorghinaeSorghum
Proteomesi
  • UP000000768 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb06g020610.1.

Structurei

3D structure databases

ProteinModelPortaliC5YAW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini420 – 571N-acetyltransferaseInterPro annotationAdd BLAST152

Sequence similaritiesi

Belongs to the ELP3 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2535. Eukaryota.
COG1243. LUCA.
HOGENOMiHOG000227514.
InParanoidiC5YAW5.
KOiK07739.
OMAiMPDLPNM.
OrthoDBiEOG093605YI.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.40.630.30. 1 hit.
InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR032432. Radical_SAM_C.
IPR007197. rSAM.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
PF16199. Radical_SAM_C. 1 hit.
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiView protein in SMART
SM00729. Elp3. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiView protein in PROSITE
PS51186. GNAT. 1 hit.

Sequencei

Sequence statusi: Complete.

C5YAW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAAAAAVA APEQPRRRKP APGRGGVALP AGISEEEARV RAIAEIVSAM
60 70 80 90 100
GELSRRGEDV DLNALKSAAC RRYGLARAPK LVEMIAAVPE ADRAALLPRL
110 120 130 140 150
RAKPVRTASG IAVVAVMSKP HRCPHIATTG NICVYCPGGP DSDFEYSTQS
160 170 180 190 200
YTGYEPTSMR AIRARYNPYV QARSRIDQLK RLGHSVDKVE FILMGGTFMS
210 220 230 240 250
LPADYRDYFI RNLHDALSGH TSANVEEAIC YSEHSAVKCI GMTIETRPDY
260 270 280 290 300
CLGPHLRQML SYGCTRLEIG VQSTYEDVAR DTNRGHTVAA VADCFCLAKD
310 320 330 340 350
AGFKVVAHMM PDLPNVGVER DLESFREFFE SPAFRADGLK IYPTLVIRGT
360 370 380 390 400
GLYELWKTGR YRNYPPELLV DIVARILSMV PPWTRVYRVQ RDIPMPLVTS
410 420 430 440 450
GVEKGNLREL ALARMEDLGL KCRDVRTREA GIQDIHHKIR PDEVELVRRD
460 470 480 490 500
YAANEGWETF LSYEDTRQDI LIGLLRLRKC GRNVTCPELV GRCSIVRELH
510 520 530 540 550
VYGTAVPVHG RDVDKLQHQG YGTLLMEEAE RIAQKEHRSK KLAVISGVGT
560 570
RHYYRKLGYE LEGPYMVKTL A
Length:571
Mass (Da):63,730
Last modified:September 1, 2009 - v1
Checksum:iF47E75BA5414D7D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000765 Genomic DNA. Translation: EES12405.1.
RefSeqiXP_002448077.1. XM_002448032.1.
UniGeneiSbi.7389.

Genome annotation databases

EnsemblPlantsiSb06g020610.1; Sb06g020610.1; Sb06g020610.
GeneIDi8073682.
GrameneiSb06g020610.1; Sb06g020610.1; Sb06g020610.
KEGGisbi:SORBI_06g020610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000765 Genomic DNA. Translation: EES12405.1.
RefSeqiXP_002448077.1. XM_002448032.1.
UniGeneiSbi.7389.

3D structure databases

ProteinModelPortaliC5YAW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4558.Sb06g020610.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSb06g020610.1; Sb06g020610.1; Sb06g020610.
GeneIDi8073682.
GrameneiSb06g020610.1; Sb06g020610.1; Sb06g020610.
KEGGisbi:SORBI_06g020610.

Phylogenomic databases

eggNOGiKOG2535. Eukaryota.
COG1243. LUCA.
HOGENOMiHOG000227514.
InParanoidiC5YAW5.
KOiK07739.
OMAiMPDLPNM.
OrthoDBiEOG093605YI.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.40.630.30. 1 hit.
InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR032432. Radical_SAM_C.
IPR007197. rSAM.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
PF16199. Radical_SAM_C. 1 hit.
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiView protein in SMART
SM00729. Elp3. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiView protein in PROSITE
PS51186. GNAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC5YAW5_SORBI
AccessioniPrimary (citable) accession number: C5YAW5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 12, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.