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Protein

Glutathione synthetase

Gene

Sb05g025630

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutathione synthase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Glutathione biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00142; UER00210.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
Short name:
GSH-SUniRule annotation
Gene namesi
Name:Sb05g025630Imported
ORF Names:SORBIDRAFT_05g025630Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum
ProteomesiUP000000768: Chromosome 5

Organism-specific databases

GrameneiC5Y715.

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb05g025630.1.

Structurei

3D structure databases

ProteinModelPortaliC5Y715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic GSH synthase family.UniRule annotation

Phylogenomic databases

eggNOGiNOG329040.
HOGENOMiHOG000172641.
InParanoidiC5Y715.
KOiK01920.

Family and domain databases

Gene3Di1.10.1080.10. 2 hits.
3.30.1490.50. 1 hit.
3.30.1490.80. 1 hit.
3.40.50.1760. 1 hit.
InterProiIPR004887. Glutathione_synth_subst-bd_euk.
IPR014042. Glutathione_synthase_a-hlx_euk.
IPR014709. Glutathione_synthase_dom.
IPR005615. Glutathione_synthase_euk.
IPR014049. Glutathione_synthase_N_euk.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR11130. PTHR11130. 1 hit.
PfamiPF03917. GSH_synth_ATP. 2 hits.
PF03199. GSH_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001558. GSHase. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01986. glut_syn_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

C5Y715-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAEARPGVA PAEEGAATPG QQQALLAEMV ENAAVWCAVH GLVVGDRANQ
60 70 80 90 100
RSGTVPGVGL VHAPFSLLPA RFPASFWKQA CELAPIFNEL VDRVSLDGEF
110 120 130 140 150
LQAALSRQVL KSIHWVLSSG HRRPDYSSFS QLYNGFRTKQ VDEFTARLLQ
160 170 180 190 200
IHEKMMPINK KEDIRLGLHR SDYMLDSETN SLLQIELNTI SSSFPGLGSL
210 220 230 240 250
VSELHRTLLN QYGKILGLDP KRIPQNWAAT QFAEALGKAW AEYNNDRISR
260 270 280 290 300
KSITYGVATI RKTLAQVEAE GQVLTDGTLV IDGRTVAVVY FRAGYAPTDY
310 320 330 340 350
PSEVEWRARL LMEQSSAIKC PSISYHLVGT KKIQQELAKP NVLERFLDNK
360 370 380 390 400
EDIAKLRKSF AGLWSLDNEE IVKSAIEKPD LFVLKPQREG GGNNIYGHDL
410 420 430 440 450
RDTLIKLQKE QGESLAAYIL MQRIFPKASL TPLVRGGDWF EDLTISELGI
460 470 480 490
YGAYLRNKDK VILNNQSGYL MRTKVSSSNE GGVAAGFAVL DSVLLTDE
Length:498
Mass (Da):55,221
Last modified:September 1, 2009 - v1
Checksum:i1771DBEAB7C2F346
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000764 Genomic DNA. Translation: EES10181.1.
RefSeqiXP_002451193.1. XM_002451148.1.
UniGeneiSbi.20744.

Genome annotation databases

EnsemblPlantsiSb05g025630.1; Sb05g025630.1; Sb05g025630.
GeneIDi8068348.
KEGGisbi:SORBI_05g025630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000764 Genomic DNA. Translation: EES10181.1.
RefSeqiXP_002451193.1. XM_002451148.1.
UniGeneiSbi.20744.

3D structure databases

ProteinModelPortaliC5Y715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4558.Sb05g025630.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSb05g025630.1; Sb05g025630.1; Sb05g025630.
GeneIDi8068348.
KEGGisbi:SORBI_05g025630.

Organism-specific databases

GrameneiC5Y715.

Phylogenomic databases

eggNOGiNOG329040.
HOGENOMiHOG000172641.
InParanoidiC5Y715.
KOiK01920.

Enzyme and pathway databases

UniPathwayiUPA00142; UER00210.

Family and domain databases

Gene3Di1.10.1080.10. 2 hits.
3.30.1490.50. 1 hit.
3.30.1490.80. 1 hit.
3.40.50.1760. 1 hit.
InterProiIPR004887. Glutathione_synth_subst-bd_euk.
IPR014042. Glutathione_synthase_a-hlx_euk.
IPR014709. Glutathione_synthase_dom.
IPR005615. Glutathione_synthase_euk.
IPR014049. Glutathione_synthase_N_euk.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR11130. PTHR11130. 1 hit.
PfamiPF03917. GSH_synth_ATP. 2 hits.
PF03199. GSH_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001558. GSHase. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01986. glut_syn_euk. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. BTx623Imported.

Entry informationi

Entry nameiC5Y715_SORBI
AccessioniPrimary (citable) accession number: C5Y715
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: February 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.