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Protein

Histone deacetylase

Gene

SORBI_004G091200

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei113SubstrateUniRule annotation1
Active sitei154Proton acceptorUniRule annotation1
Binding sitei162Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi189Divalent metal cationUniRule annotation1
Metal bindingi191Divalent metal cationUniRule annotation1
Metal bindingi277Divalent metal cationUniRule annotation1
Binding sitei316SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:SORBI_004G091200Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeSorghinaeSorghum
Proteomesi
  • UP000000768 Componenti: Chromosome 4

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb04g007470.1.

Structurei

3D structure databases

ProteinModelPortaliC5XY14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 329Hist_deacetylInterPro annotationAdd BLAST288

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.
InParanoidiC5XY14.
KOiK06067.
OMAiKCVEFVR.
OrthoDBiEOG093609CH.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

C5XY14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSSAGSGG NSLPSVGADG QKRRVCYFYD SDVGNYYYGQ GHPMKPHRIR
60 70 80 90 100
MTHSLLARYG LLNQMQVYRP NPARDRDLCR FHADDYINFL RSVTPETQQD
110 120 130 140 150
QIRLLKRFNV GEDCPVFDGL YSFCQTYAGA SVGGAVKLNH GHDIAINWSG
160 170 180 190 200
GLHHAKKCEA SGFCYVNDIV LAILELLKHH ERVLYVDIDI HHGDGVEEAF
210 220 230 240 250
YTTDRVMTVS FHKFGDYFPG TGDIRDIGHS KGKYYSLNVP LDDGIDDESY
260 270 280 290 300
QSLFKPIMGK VMEVFRPGAV VLQCGADSLS GDRLGCFNLS IRGHAECVRY
310 320 330 340 350
MRSFNVPLLL LGGGGYTIRN VARCWCYETG VALGQELEDK MPVNEYYEYF
360 370 380 390 400
GPDYTLHVAP SNMENKNTRN QLDDIRSKLL DNLSKLRHAP SVQFQERVPD
410 420 430 440 450
TEVPEPDEDQ DDPDERHDPD SDMEVDDHKA VEESARRSIP GIKVKREFGE
460 470 480 490 500
NETKVQDGGR IASDHRGVEP MAEDIGSSKQ APQADASAMA VDEPSNVKNE
510
PESSTKLQDQ AAAYHKP
Length:517
Mass (Da):57,885
Last modified:September 1, 2009 - v1
Checksum:iB61250EA8BC725EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000763 Genomic DNA. Translation: EES04741.1.
RefSeqiXP_002451765.1. XM_002451720.1.
UniGeneiSbi.15980.

Genome annotation databases

EnsemblPlantsiEES04741; EES04741; SORBI_004G091200.
GeneIDi8082952.
GrameneiEES04741; EES04741; SORBI_004G091200.
KEGGisbi:SORBI_04g007470.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiC5XY14_SORBI
AccessioniPrimary (citable) accession number: C5XY14
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: July 5, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported