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Protein

Eukaryotic translation initiation factor 6

Gene

Sb03g011410

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

  1. ribosomal large subunit binding Source: UniProtKB-HAMAP
  2. ribosome binding Source: EnsemblPlants/Gramene
  3. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. embryo development ending in seed dormancy Source: EnsemblPlants/Gramene
  2. mature ribosome assembly Source: UniProtKB-HAMAP
  3. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factorUniRule annotation

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:Sb03g011410Imported
Synonyms:EIF6UniRule annotationImported, EIF6-1Imported
ORF Names:SORBIDRAFT_03g011410Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum
ProteomesiUP000000768: Chromosome 3

Organism-specific databases

GrameneiC5XHC8.

Subcellular locationi

Cytoplasm UniRule annotation. Nucleusnucleolus UniRule annotation
Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi4558.Sb03g011410.1.

Structurei

3D structure databases

ProteinModelPortaliC5XHC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1976.
HOGENOMiHOG000230605.
InParanoidiC5XHC8.
KOiK03264.
OMAiGSFCAFS.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

C5XHC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRVKFENS CEVGVFARLT NAYCLVPAGA ASQGFYSVLE GELAGAVPVV
60 70 80 90 100
RTSVAGTRIV GRLCVGNKRG LLLPHTATDQ EIQHLRNSLP DEVVVKCVDE
110 120 130 140 150
RLSALGNCIA CNDHVALTHP DLDKETEEVI SDVLGVEVFR QTIAGNILVG
160 170 180 190 200
SYCTFTNKGG LVHPQTSVED LDELSTLLQV PMVAGTVNRG SEVVSAGMAV
210 220 230 240 250
NDWTAFCGSD TTATEVSVVE SVFRLRDPRA GALGSVQDFF TSGAGLLPEP

RQKTRLC
Length:257
Mass (Da):27,322
Last modified:September 1, 2009 - v1
Checksum:i6DD2937B50820C0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000762 Genomic DNA. Translation: EES02790.1.
RefSeqiXP_002457670.1. XM_002457625.1.
UniGeneiSbi.5473.

Genome annotation databases

EnsemblPlantsiSb03g011410.1; Sb03g011410.1; Sb03g011410.
GeneIDi8078117.
KEGGisbi:SORBI_03g011410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000762 Genomic DNA. Translation: EES02790.1.
RefSeqiXP_002457670.1. XM_002457625.1.
UniGeneiSbi.5473.

3D structure databases

ProteinModelPortaliC5XHC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4558.Sb03g011410.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSb03g011410.1; Sb03g011410.1; Sb03g011410.
GeneIDi8078117.
KEGGisbi:SORBI_03g011410.

Organism-specific databases

GrameneiC5XHC8.

Phylogenomic databases

eggNOGiCOG1976.
HOGENOMiHOG000230605.
InParanoidiC5XHC8.
KOiK03264.
OMAiGSFCAFS.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. BTx623Imported.

Entry informationi

Entry nameiC5XHC8_SORBI
AccessioniPrimary (citable) accession number: C5XHC8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: January 7, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.