Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mediator of RNA polymerase II transcription subunit 4

Gene

MED4

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 4UniRule annotation
Alternative name(s):
Mediator complex subunit 4UniRule annotation
Gene namesi
Name:MED4UniRule annotation
ORF Names:SORBI_3002G280600Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeSorghinaeSorghum
Proteomesi
  • UP000000768 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Component of the Mediator complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 4 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IVDD. Eukaryota.
ENOG410Y5NG. LUCA.
HOGENOMiHOG000243278.
InParanoidiC5X6W5.
OMAiMMQSHLP.
OrthoDBiEOG09360LES.

Family and domain databases

InterProiView protein in InterPro
IPR019258. Mediator_Med4.
PANTHERiPTHR13208. PTHR13208. 1 hit.
PfamiView protein in Pfam
PF10018. Med4. 1 hit.

Sequencei

Sequence statusi: Complete.

C5X6W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQSHLPSPA RLGLTASSPS LPPNPVPLNP TSSPPPGSLP SSAAAGASAA
60 70 80 90 100
PTLTTSPSLL PLLPPLPRAQ SLLQLISSLA SNLFELSPNR AAWIQAYRGS
110 120 130 140 150
FPTFLPSASS SAPPLPTPIS STKDALSLLT TLQTQLFEAV AELQETLDLQ
160 170 180 190 200
DARARLAREA RAKDAALVAF AKKLHEAHQV LDRLVDDYAD YRRDPKRPRG
210 220 230 240 250
AAAADDPEPA SEGDFGTSLH SSLKLDDILA YAHRISYTTF APPEHGAGLP
260 270 280 290 300
LRVSLPPVPQ ENQMRASQLY LFADLDVGVP KKPLDAKEGI AAEVEAAPLY
310 320 330 340 350
EPPQEGPSRL PNTLPPMFPK ELKPPPGWKP GDPITLPPDE ILPGIKGEEP
360 370 380 390 400
QAPVPQPHVP VRPVAPMGAE PIQVQPVQLD FDSSSSDEYS SDVGSSEEDD

ED
Length:402
Mass (Da):42,767
Last modified:September 1, 2009 - v1
Checksum:i3D4F58BDC17C0D6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000761 Genomic DNA. Translation: EER99271.1.
CM000761 Genomic DNA. Translation: KXG36089.1.
CM000761 Genomic DNA. Translation: OQU89839.1.
RefSeqiXP_002462750.1. XM_002462705.1.

Genome annotation databases

EnsemblPlantsiEER99271; EER99271; SORBI_002G280600.
KXG36089; KXG36089; SORBI_002G280600.
GrameneiEER99271; EER99271; SORBI_002G280600.
KXG36089; KXG36089; SORBI_002G280600.

Similar proteinsi

Entry informationi

Entry nameiC5X6W5_SORBI
AccessioniPrimary (citable) accession number: C5X6W5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: January 31, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported