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Protein

Inositol-tetrakisphosphate 1-kinase

Gene

Sb01g027420

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.UniRule annotation

Catalytic activityi

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol-1,3,4-trisphosphate 5-kinase activity Source: InterPro
  3. inositol-1,3,4-trisphosphate 6-kinase activity Source: InterPro
  4. inositol tetrakisphosphate 1-kinase activity Source: UniProtKB-EC
  5. magnesium ion binding Source: InterPro

GO - Biological processi

  1. inositol trisphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-tetrakisphosphate 1-kinaseUniRule annotation (EC:2.7.1.134UniRule annotation)
Gene namesi
Name:Sb01g027420Imported
ORF Names:SORBIDRAFT_01g027420Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum
ProteomesiUP000000768: Chromosome 1

Organism-specific databases

GrameneiC5WQI3.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi4558.Sb01g027420.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the ITPK1 family.UniRule annotation

Phylogenomic databases

eggNOGiNOG85132.
HOGENOMiHOG000220790.
InParanoidiC5WQI3.
KOiK00913.
OMAiCIAELPP.

Family and domain databases

InterProiIPR008656. Inositol_tetrakis-P_1-kinase.
IPR017427. Inositol_tetrakis-P_kinase_pln.
[Graphical view]
PfamiPF05770. Ins134_P3_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF038186. ITPK. 1 hit.

Sequencei

Sequence statusi: Complete.

C5WQI3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRVHGEVSDD EAGAAAAAVT VVGETVVPSS PPPASAAGQQ QQQPQQLVVG
60 70 80 90 100
YALTKKKVKS FLQPKLLALA RKKGIHFVSI DETCPLSEQG PFDIILHKLT
110 120 130 140 150
SKEWQQVLED YREEHPEVTV LDPPNAIQHL HNRQSMLQEV ADLNLSDGYG
160 170 180 190 200
EVCAPRQLVI MKDPSSIPDA VAKAGLSLPL VAKPLVADGT SKSHELSLAY
210 220 230 240 250
VEASLPLLDP PLVLQEFVNH GGILFKVYIV GETIQVVRRF SLPDVNTYDL
260 270 280 290 300
GNNDGIFRFP RVSCATNNAE DADVDPCIAE LPPKPLLEKL GKELRRRLGL
310 320 330 340 350
RLFNIDIIRE HGRKDRYYVI DINYFPGYGK MPGYEHIFTD FLLSLVQSKY

KRHLSGS
Length:357
Mass (Da):39,514
Last modified:September 1, 2009 - v1
Checksum:iAB11A6373F018020
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000760 Genomic DNA. Translation: EER91837.1.
RefSeqiXP_002464839.1. XM_002464794.1.
UniGeneiSbi.11944.

Genome annotation databases

EnsemblPlantsiSb01g027420.1; Sb01g027420.1; Sb01g027420.
GeneIDi8055098.
KEGGisbi:SORBI_01g027420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000760 Genomic DNA. Translation: EER91837.1.
RefSeqiXP_002464839.1. XM_002464794.1.
UniGeneiSbi.11944.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4558.Sb01g027420.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSb01g027420.1; Sb01g027420.1; Sb01g027420.
GeneIDi8055098.
KEGGisbi:SORBI_01g027420.

Organism-specific databases

GrameneiC5WQI3.

Phylogenomic databases

eggNOGiNOG85132.
HOGENOMiHOG000220790.
InParanoidiC5WQI3.
KOiK00913.
OMAiCIAELPP.

Family and domain databases

InterProiIPR008656. Inositol_tetrakis-P_1-kinase.
IPR017427. Inositol_tetrakis-P_kinase_pln.
[Graphical view]
PfamiPF05770. Ins134_P3_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF038186. ITPK. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. BTx623Imported.

Entry informationi

Entry nameiC5WQI3_SORBI
AccessioniPrimary (citable) accession number: C5WQI3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: February 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.