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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Streptococcus dysgalactiae subsp. equisimilis (strain GGS_124)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei259ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDYS486410:GHH8-1963-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotationImported
Ordered Locus Names:SDEG_1967Imported
OrganismiStreptococcus dysgalactiae subsp. equisimilis (strain GGS_124)Imported
Taxonomic identifieri486410 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002732 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC5WJ84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 327tRNA-synt_1cInterPro annotationAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 22"HIGH" regionUniRule annotationAdd BLAST11
Motifi256 – 260"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252720.
KOiK09698.
OMAiAYYAFDT.

Family and domain databases

CDDicd00808. GluRS_core. 1 hit.
Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022. Glu_tRNA_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR033910. GluRS_core.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

C5WJ84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKPIRVRY APSPTGLLHI GNARTALFNY LYARHHGGTF IIRIEDTDRK
60 70 80 90 100
RHVEDGERSQ LENLKWLGMD WDESPETHEQ YRQSERLDLY QKYIDQLLAE
110 120 130 140 150
GKAYKSYVTE DELAAERERQ EAAGETPRYI NEFLGMTEEQ KAAYIAEREA
160 170 180 190 200
AGIVPTVRLA VNEAGIYKWT DMVKGDIEFE GGNIGGDWVI QKKDGYPTYN
210 220 230 240 250
FAVVVDDHDM QISHVIRGDD HIANTPKQLM VYEALGWEAP AFGHMTLIIN
260 270 280 290 300
SETGKKLSKR DTNTLQFIED YRKKGYMPEA VFNFIALLGW NPGGEEEIFS
310 320 330 340 350
REQLIDLFDE NRLSKSPAAF DQKKMDWMSN EYLKNADFET VYALCKPFLE
360 370 380 390 400
EACRLTEKAE KLVELYKPQL KSADEIIPLT DLFFSDFPEL TEAEKEVMAG
410 420 430 440 450
ETVPTVLQAF KEKLEAMSDE DFKPENIFPQ IKAVQKETGI KGKNLFMPIR
460 470 480
IAVSGEMHGP ELPNTIYLLG RDKSIEHINK ML
Length:482
Mass (Da):55,309
Last modified:September 1, 2009 - v1
Checksum:i628752723E30BB6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010935 Genomic DNA. Translation: BAH82449.1.
RefSeqiWP_012767571.1. NC_012891.1.

Genome annotation databases

EnsemblBacteriaiBAH82449; BAH82449; SDEG_1967.
KEGGisds:SDEG_1967.

Similar proteinsi

Entry informationi

Entry nameiC5WJ84_STRDG
AccessioniPrimary (citable) accession number: C5WJ84
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: January 31, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported