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C5WIY3

- C5WIY3_STRDG

UniProt

C5WIY3 - C5WIY3_STRDG

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Protein
Alanine racemase
Gene
acpS, alr, SDEG_1866
Organism
Streptococcus dysgalactiae subsp. equisimilis (strain GGS_124)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei136 – 1361Substrate By similarityUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSDYS486410:GHH8-1862-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:acpSImported
Synonyms:alrImported
Ordered Locus Names:SDEG_1866Imported
OrganismiStreptococcus dysgalactiae subsp. equisimilis (strain GGS_124)Imported
Taxonomic identifieri486410 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002732: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi486410.SDEG_1866.

Structurei

3D structure databases

ProteinModelPortaliC5WIY3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiIYSHLAL.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5WIY3-1 [UniParc]FASTAAdd to Basket

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MISSFHRPTV ARVNLQAIKE NVASVQENIP LGVRTYAVVK ADAYGHGAVQ    50
VSKALLPQVD GYCVSNLDEA LQLRQAGIDK EILILGVLLP NELELAITRQ 100
VTVTVASLEW LAMAKQEWPD LKGLKVHIKI DSGMGRIGLR SVTEVDNLIA 150
GLKSMRAEVE GIFTHFATAD EADTVKFEQQ LTFFTNLVDQ LADKPSLVHA 200
SNSATSLWHS ETIFNAVRLG IVMYGLNPSG SELALPFPLK EAFNLESVLV 250
HVKEIAPGET VGYGATYKAQ TSEYVGTVPI GYADGWTRDM QGFTVLVEGQ 300
PCEIIGRVSM DQMTIRLPRA YPLGTKVTLI GQDQEKVIST TDIANYRNTI 350
NYEVLCLLSD RVPRVY 366
Length:366
Mass (Da):40,175
Last modified:September 1, 2009 - v1
Checksum:i4F2963FFA4F042A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010935 Genomic DNA. Translation: BAH82348.1.
RefSeqiYP_002997562.1. NC_012891.1.

Genome annotation databases

EnsemblBacteriaiBAH82348; BAH82348; SDEG_1866.
GeneIDi8110874.
KEGGisds:SDEG_1866.
PATRICi19644022. VBIStrDys95162_1835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010935 Genomic DNA. Translation: BAH82348.1 .
RefSeqi YP_002997562.1. NC_012891.1.

3D structure databases

ProteinModelPortali C5WIY3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 486410.SDEG_1866.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH82348 ; BAH82348 ; SDEG_1866 .
GeneIDi 8110874.
KEGGi sds:SDEG_1866.
PATRICi 19644022. VBIStrDys95162_1835.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi IYSHLAL.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SDYS486410:GHH8-1862-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS)."
    Shimomura Y., Okumura K., Murayama S.Y., Yagi J., Ubukata K., Kirikae T., Miyoshi-Akiyama T.
    BMC Genomics 12:17-17(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GGS_124Imported.

Entry informationi

Entry nameiC5WIY3_STRDG
AccessioniPrimary (citable) accession number: C5WIY3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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