C5WII1 (C5WII1_STRDG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase HAMAP MF_00193 RuleBase RU003812
EC=6.3.1.5 HAMAP MF_00193 RuleBase RU003812

Gene names

Name:	nadE HAMAP MF_00193 EMBL BAH82196.1
Ordered Locus Names:	SDEG_1713

Organism

Streptococcus dysgalactiae subsp. equisimilis (strain GGS_124) [Complete proteome] [HAMAP]

Taxonomic identifier

486410 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193 RuleBase RU003812 SAAS SAAS003694
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193 RuleBase RU004252 SAAS SAAS003694
Sequence similarities	Belongs to the NAD synthetase family. HAMAP MF_00193 RuleBase RU003811

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_00193 SAAS SAAS003694 RuleBase RU003811 NAD HAMAP MF_00193 SAAS SAAS003694 RuleBase RU003811 Nucleotide-binding
Molecular function	Ligase SAAS SAAS003694 HAMAP MF_00193 RuleBase RU003811 EMBL BAH82196.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	60 – 67	8	ATP By similarity HAMAP MF_00193
Sites
	Active site	62	1	By similarity HAMAP MF_00193

Sequences

	Sequence		Length	Mass (Da)
	C5WII1 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: 43281CDACE988C81	FASTA	288	31,848
	10 20 30 40 50 60 MIKFAKMLME RVSDMTLQEE IIRQLGVKAS IDPKEEIRKT VDFLKAYLRK HSFLETYVLG 70 80 90 100 110 120 ISGGQDSTLA GKLAQMAIAE LREQTGDQAY QFIAVRLPYG VQADEADAQK ALAFIMPDQT 130 140 150 160 170 180 LTINIKAAVD GQVEALQAAG VEISDFNKGN IKARQRMISQ YAIAGQMAGA VIGTDHAAEN 190 200 210 220 230 240 ITGFFTKFGD GGADILPLFR LNKRQGKALL QVLGADSALY EKVPTADLED QKPGLADEVA 250 260 270 280 LGVTYQEIDD YLEGKLISEA AQATIEKWWH KGQHKRHLPI TIFDNFWK

References

[1]

"Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS)." Shimomura Y., Okumura K., Murayama S.Y., Yagi J., Ubukata K., Kirikae T., Miyoshi-Akiyama T. BMC Genomics 12:17-17(2011) [PubMed: 21223537] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GGS_124.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP010935 Genomic DNA. Translation: BAH82196.1.
RefSeq	YP_002997410.1. NC_012891.1.
3D structure databases
ProteinModelPortal	C5WII1.
ModBase	Search...
Protein-protein interaction databases
STRING	C5WII1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000083271; EBSTRP00000076564; EBSTRG00000081967.
GeneID	8111274.
GenomeReviews	Gene locus SDEG_1713 in contig AP010935_GR.
KEGG	sds:SDEG_1713.
PATRIC	19643722. VBIStrDys95162_1686.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027750.
OMA	IAQYEIA.
ProtClustDB	PRK00768.
Family and domain databases
HAMAP	MF_00193. NadE. [Tree]
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR022926. NH(3)-dep_NAD(+)_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01916.
Pfam	PF02540. NAD_synthase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C5WII1_STRDG

Accession

Primary (citable) accession number: C5WII1

Entry history

Integrated into UniProtKB/TrEMBL:	September 1, 2009
Last sequence update:	September 1, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)