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C5WG96 (C5WG96_STRDG) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length834 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1201O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
C5WG96 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 8D531DC043444921

FASTA83493,126
        10         20         30         40         50         60 
MQDRNLIDVN LTSEMKTSFI DYAMSVIVAR ALPDVRDGLK PVHRRILYGM NELGVMPDKP 

        70         80         90        100        110        120 
HKKSARITGD VMGKYHPHGD SSIYEAMVRM AQWWSYRHML VDGHGNFGSM DGDGAAAQRY 

       130        140        150        160        170        180 
TEARMSKIAL ELLRDINKNT VDFQDNYDGS EREPLVLPAR FPNLLVNGAT GIAVGMATNI 

       190        200        210        220        230        240 
PPHNLAESID AVKMVMENPD CTTRDLMEVI PGPDFPTGAL VMGRSGIHRA YDTGKGSIVL 

       250        260        270        280        290        300 
RSRTEIETTK TGRERIVVTE FPYGVNKTKV HEHIVRLAQE KRIEGITAVR DESSREGVRF 

       310        320        330        340        350        360 
VIEIRRDASA NVILNNLFKL TSLQTNFSFN MLAIENGVPK ILSLRQIIDN YISHQKEVIT 

       370        380        390        400        410        420 
RRTQFDKNKA EARAHILEGL LIALDHLDEV IAIIRNSETD VIAQAELMSR FNLSERQSQA 

       430        440        450        460        470        480 
ILDMRLRRLT GLERDKIQSE YDELLALIAD LADILAKPER VVTIIKEEMD EIKRKYANSR 

       490        500        510        520        530        540 
RTELMIGEVL SLEDEDLIEE EDVLITLSNK GYIKRLAQDE FRAQKRGGRG VQGTGVNDDD 

       550        560        570        580        590        600 
FVRELVSTST HDTLLFFTNF GRVYRLKAYE IPEYGRTAKG LPIVNLLKLE DGETIQTIIN 

       610        620        630        640        650        660 
ARKEETAGKS FFFTTKQGVV KRTEVSEFNN IRQNGLRALN LKEGDQLINV LLTNGQDDII 

       670        680        690        700        710        720 
IGTQSGYSVR FNEASIRNMG RSATGVRGVS LREDDRVVGA SRINDHQEVL VITENGYGKR 

       730        740        750        760        770        780 
TEATEYPTKG RGGKGIKTAN ITPKNGQLAG LVTVDGTEDI MVITNKGVII RTNVANISQT 

       790        800        810        820        830 
GRATLGVKVM KLDADAKIVT FALVQADDEE ETIGEVEQSQ IPAAADTTPN NDKE

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References

[1]"Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS)."
Shimomura Y., Okumura K., Murayama S.Y., Yagi J., Ubukata K., Kirikae T., Miyoshi-Akiyama T.
BMC Genomics 12:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GGS_124 EMBL BAH81411.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP010935 Genomic DNA. Translation: BAH81411.1.
RefSeqYP_002996625.1. NC_012891.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING486410.SDEG_0912.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH81411; BAH81411; SDEG_0912.
GeneID8110890.
KEGGsds:SDEG_0912.
PATRIC19642095. VBIStrDys95162_0888.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycSDYS486410:GHH8-1688-MONOMER.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC5WG96_STRDG
AccessionPrimary (citable) accession number: C5WG96
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info