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Protein

Elongation factor Tu

Gene

tuf

Organism
Streptococcus dysgalactiae subsp. equisimilis (strain GGS_124)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi25 – 328GTPUniRule annotation
Nucleotide bindingi90 – 945GTPUniRule annotation
Nucleotide bindingi145 – 1484GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDYS486410:GHH8-624-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:SDEG_0625Imported
OrganismiStreptococcus dysgalactiae subsp. equisimilis (strain GGS_124)Imported
Taxonomic identifieri486410 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002732 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi486410.SDEG_0625.

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiHYRPQLF.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5WFG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAFPKMAKE KYDRSKPHVN IGTIGHVDHG KTTLTAAITT VLARRLPTSV
60 70 80 90 100
NQPKDYASID AAPEERERGI TINTAHVEYE TETRHYAHID APGHADYVKN
110 120 130 140 150
MITGAAQMDG AILVVASTDG PMPQTREHIL LSRQVGVKHL IVFMNKVDLV
160 170 180 190 200
DDEELLELVE MEIRDLLSEY DFPGDDLPVI QGSALKALEG DSKYEDIIME
210 220 230 240 250
LMSTVDEYIP EPERDTDKPL LLPVEDVFSI TGRGTVASGR IDRGTVRVND
260 270 280 290 300
EIEIVGIKEE TKKAVVTGVE MFRKQLDEGL AGDNVGILLR GVQRDEIERG
310 320 330 340 350
QVIAKPGSIN PHTKFKGEVY ILSKDEGGRH TPFFNNYRPQ FYFRTTDVTG
360 370 380 390 400
SIELPAGTEM VMPGDNVTIN VELIHPIAVE QGTTFSIREG GRTVGSGIVS

EIEA
Length:404
Mass (Da):44,617
Last modified:September 1, 2009 - v1
Checksum:i4CA833CC5583B204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010935 Genomic DNA. Translation: BAH81127.1.
RefSeqiWP_012766716.1. NC_012891.1.
YP_002996341.1. NC_012891.1.

Genome annotation databases

EnsemblBacteriaiBAH81127; BAH81127; SDEG_0625.
KEGGisds:SDEG_0625.
PATRICi19641497. VBIStrDys95162_0590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010935 Genomic DNA. Translation: BAH81127.1.
RefSeqiWP_012766716.1. NC_012891.1.
YP_002996341.1. NC_012891.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi486410.SDEG_0625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH81127; BAH81127; SDEG_0625.
KEGGisds:SDEG_0625.
PATRICi19641497. VBIStrDys95162_0590.

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiHYRPQLF.
OrthoDBiEOG6R5C6X.

Enzyme and pathway databases

BioCyciSDYS486410:GHH8-624-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS)."
    Shimomura Y., Okumura K., Murayama S.Y., Yagi J., Ubukata K., Kirikae T., Miyoshi-Akiyama T.
    BMC Genomics 12:17-17(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GGS_124Imported.

Entry informationi

Entry nameiC5WFG2_STRDG
AccessioniPrimary (citable) accession number: C5WFG2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 29, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.