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C5VWZ7

- C5VWZ7_STRSE

UniProt

C5VWZ7 - C5VWZ7_STRSE

Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

pheS

Organism
Streptococcus suis (strain P1/7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per tetramer.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi262 – 2621MagnesiumUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
    4. tRNA binding Source: InterPro

    GO - Biological processi

    1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSUI218494:GJDS-1043-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phenylalanine--tRNA ligase alpha subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
    Alternative name(s):
    Phenylalanyl-tRNA synthetase alpha subunitUniRule annotation
    Gene namesi
    Name:pheSUniRule annotationImported
    Ordered Locus Names:SSU0997Imported
    OrganismiStreptococcus suis (strain P1/7)Imported
    Taxonomic identifieri218494 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002055: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi218494.SSU0997.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0016.
    HOGENOMiHOG000242675.
    KOiK01889.
    OMAiIRYFFEN.
    OrthoDBiEOG6WX4QN.

    Family and domain databases

    HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view]
    PfamiPF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view]
    SUPFAMiSSF46589. SSF46589. 1 hit.
    TIGRFAMsiTIGR00468. pheS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5VWZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNIEQQLAE LSQTTLEKLK EIQHQGEKEL QDLRVAVLGK KGSLTDLLKG    50
    LKDLSNDMKP IVGKQVNEVR DVLTTAFEET AQKVAAAKIQ QQLASETIDV 100
    TLPGRQVKVG KRHVLTQTSE EIEDIFLGMG FQIVDGFEVE KDYYNFERMN 150
    LPKDHPARDM QDTFYITEEI LMRTHTSPVQ ARTMDQHDFS KGALKMISPG 200
    RVFRRDTDDA THSHQFHQIE GLVVGENVSM GDLKGTLEMI IKKMFGEERQ 250
    IRLRPSYFPF TEPSVEVDVS CFKCGGDGCN VCKKTGWIEI LGAGMVHPQV 300
    LEMSGIDSTK YSGFAFGLGQ ERIAMLRYGI NDIRGFYQGD VRFSEQF 347
    Length:347
    Mass (Da):39,209
    Last modified:September 1, 2009 - v1
    Checksum:iE7BBDD7F94A56936
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM946016 Genomic DNA. Translation: CAR46091.1.
    RefSeqiYP_003026859.1. NC_012925.1.

    Genome annotation databases

    EnsemblBacteriaiCAR46091; CAR46091; SSU0997.
    GeneIDi8151608.
    KEGGissi:SSU0997.
    PATRICi19786900. VBIStrSui84581_0956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM946016 Genomic DNA. Translation: CAR46091.1 .
    RefSeqi YP_003026859.1. NC_012925.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218494.SSU0997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR46091 ; CAR46091 ; SSU0997 .
    GeneIDi 8151608.
    KEGGi ssi:SSU0997.
    PATRICi 19786900. VBIStrSui84581_0956.

    Phylogenomic databases

    eggNOGi COG0016.
    HOGENOMi HOG000242675.
    KOi K01889.
    OMAi IRYFFEN.
    OrthoDBi EOG6WX4QN.

    Enzyme and pathway databases

    BioCyci SSUI218494:GJDS-1043-MONOMER.

    Family and domain databases

    HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view ]
    Pfami PF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46589. SSF46589. 1 hit.
    TIGRFAMsi TIGR00468. pheS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: P1/7Imported.

    Entry informationi

    Entry nameiC5VWZ7_STRSE
    AccessioniPrimary (citable) accession number: C5VWZ7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3