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C5Q9D1 (C5Q9D1_STAEP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL EES58261.1
ORF Names:HMPREF0789_1205 EMBL EES58261.1
OrganismStaphylococcus epidermidis BCM-HMP0060 EMBL EES58261.1
Taxonomic identifier525374 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding9 – 146NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding32 – 343NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding73 – 753NADP By similarity PIRSR PIRSR000109-3
Region127 – 1293Substrate binding By similarity PIRSR PIRSR000109-2
Region185 – 1862Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1821Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1891Proton donor By similarity PIRSR PIRSR000109-1
Binding site1011NADP By similarity PIRSR PIRSR000109-3
Binding site1011Substrate By similarity PIRSR PIRSR000109-2
Binding site1901Substrate By similarity PIRSR PIRSR000109-2
Binding site2591Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2861Substrate By similarity PIRSR PIRSR000109-2
Binding site4441Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4501Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
C5Q9D1 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: A4738F224237494E

FASTA46852,234
        10         20         30         40         50         60 
MTQQIGVVGL AVMGKNLAWN IESRGYSVSV YNRSRQKTDE MVKESPGREI YPTYSLEEFV 

        70         80         90        100        110        120 
ESLEKPRKIL LMVKAGPATD ATIDGLLPLL DDDDILIDGG NTNYQDTIRR NKALAESSIN 

       130        140        150        160        170        180 
FIGMGVSGGE IGALTGPSLM PGGQKDAYNK VSDILDAIAA KAQDGASCVT YIGPNGAGHY 

       190        200        210        220        230        240 
VKMVHNGIEY ADMQLIAESY AMMKDLLGMS HKEISQTFKE WNAGELESYL IEITGDIFNK 

       250        260        270        280        290        300 
LDDDNEALVE KILDTAGQKG TGKWTSINAL ELGVPLTIIT ESVFARFISS IKEERVTASK 

       310        320        330        340        350        360 
SLKGPKAHFE GDKKTFLEKI RKALYMSKIC SYAQGFAQMR KASEDNEWNL KLGELAMIWR 

       370        380        390        400        410        420 
EGCIIRAQFL QKIKDAYDNN ENLQNLLLDP YFKNIVMEYQ DALREVVATS VYNGVPTPGF 

       430        440        450        460 
SASINYYDSY RSEDLPANLI QAQRDYFGAH TYERKDREGI FHTQWVEE

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ACHE01000041 Genomic DNA. Translation: EES58261.1.

3D structure databases

ProteinModelPortalC5Q9D1.
SMRC5Q9D1. Positions 6-465.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC31392750. VBIStaEpi34063_1536.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC5Q9D1_STAEP
AccessionPrimary (citable) accession number: C5Q9D1
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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