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C5PIN8

- LIPA_COCP7

UniProt

C5PIN8 - LIPA_COCP7

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Protein
Lipoyl synthase, mitochondrial
Gene
CPC735_057610
Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi136 – 1361Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi141 – 1411Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi147 – 1471Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi167 – 1671Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi171 – 1711Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi174 – 1741Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrial (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
ORF Names:CPC735_057610
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084: Unassembled WGS sequence

Subcellular locationi

Mitochondrion Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626Mitochondrion Reviewed prediction
Add
BLAST
Chaini27 – 419393Lipoyl synthase, mitochondrialUniRule annotation
PRO_0000398263Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi222929.C5PIN8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0320.
KOiK03644.
OrthoDBiEOG79KPR7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5PIN8-1 [UniParc]FASTAAdd to Basket

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MAVCAGRLKC FGNPAVSLRT AASRAYATTT SPDPAIPSSS SASSSSALPK    50
RPQTSFRDKL NAGPSFSDFL SGGNRDDARI LDPNEAYALK TALVGPKGKK 100
KEITRLPSWL KTSIPDSNNY KRIKNDLRGL GLHTVCEEAR CPNISECWGG 150
SSKSAATATI MLMGDTCTRA CRFCSVKTSK TPPPLDPHEP ENTAEALSRW 200
GLGYVVLTTV DRDDLIDGGA RHFAETVIRI KQKAPNILVE CLTGDYAGDL 250
EMVALMAKSG LDVYAHNVET VEALTPHVRD RRANFQTSLR VLKAAKAAVP 300
SLITKTSMML GLGETEEQMW DALRQLRAAN VDVVTFGQYM RPTKRHMPVH 350
EYVRPDVFEL WKDRALEMGF LYCASGPLVR SSYKAGEAFI ENVLKKRRAE 400
STGPESTNVP NVTPDAIVR 419
Length:419
Mass (Da):45,766
Last modified:September 1, 2009 - v1
Checksum:iE41CAE42605B6DEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACFW01000049 Genomic DNA. Translation: EER24391.1.
RefSeqiXP_003066536.1. XM_003066490.1.
UniGeneiCpo.6500.

Genome annotation databases

GeneIDi9692006.
KEGGicpw:CPC735_057610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACFW01000049 Genomic DNA. Translation: EER24391.1 .
RefSeqi XP_003066536.1. XM_003066490.1.
UniGenei Cpo.6500.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 222929.C5PIN8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9692006.
KEGGi cpw:CPC735_057610.

Phylogenomic databases

eggNOGi COG0320.
KOi K03644.
OrthoDBi EOG79KPR7.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735.

Entry informationi

Entry nameiLIPA_COCP7
AccessioniPrimary (citable) accession number: C5PIN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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