ID   C5PHU4_COCP7            Unreviewed;       625 AA.
AC   C5PHU4;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Histone-lysine N-methyltransferase SET9 {ECO:0000256|ARBA:ARBA00015413};
DE            EC=2.1.1.372 {ECO:0000256|ARBA:ARBA00024057};
DE   AltName: Full=Histone-lysine N-methyltransferase set9 {ECO:0000256|ARBA:ARBA00014232};
DE   AltName: Full=SET domain protein 9 {ECO:0000256|ARBA:ARBA00030653};
GN   ORFNames=CPC735_054670 {ECO:0000313|EMBL:EER24097.1};
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929 {ECO:0000313|EMBL:EER24097.1, ECO:0000313|Proteomes:UP000009084};
RN   [1] {ECO:0000313|EMBL:EER24097.1, ECO:0000313|Proteomes:UP000009084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Histone methyltransferase that trimethylates 'Lys-20' of
CC       histone H4 to form H4K20me3. {ECO:0000256|ARBA:ARBA00001984}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+)
CC         + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:64456, Rhea:RHEA-COMP:15554, Rhea:RHEA-
CC         COMP:15998, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.372;
CC         Evidence={ECO:0000256|ARBA:ARBA00023940};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EER24097.1}.
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DR   EMBL; ACFW01000049; EER24097.1; -; Genomic_DNA.
DR   RefSeq; XP_003066242.1; XM_003066196.1.
DR   AlphaFoldDB; C5PHU4; -.
DR   GeneID; 9691712; -.
DR   KEGG; cpw:CPC735_054670; -.
DR   VEuPathDB; FungiDB:CPC735_054670; -.
DR   HOGENOM; CLU_013724_0_0_1; -.
DR   OrthoDB; 1705992at2759; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0140943; F:histone H4K20 trimethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd10524; SET_Suv4-20-like; 1.
DR   Gene3D; 1.10.10.1700; Histone-lysine N-methyltransferase; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR041938; Hist-Lys_N-MTase_N.
DR   InterPro; IPR025783; Set9_fungi.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR039977; Suv4-20/Set9.
DR   PANTHER; PTHR12977:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B-RELATED; 1.
DR   PANTHER; PTHR12977; SUPPRESSOR OF VARIEGATION 4-20-RELATED; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          115..229
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          254..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          363..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          460..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          574..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..303
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..424
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   625 AA;  70356 MW;  DBE9C5314AE70B4F CRC64;
     MAPTPPPKQK GKLTLAQLAA YDDIVTDALV DRAFFWTKIR KNRPKYFAVR GVVEDDVTSI
     LLHDVIVAKD VIKAEESLLN LSGLRKYVEK LKSDKEKEWF RRHLRKYIAI YLPDCPFEVT
     TTNRYTITTH EAALSARKFI RTGDTIKHLS GTLVAITPEE EKTLDLTRRD FSIVMSSRKK
     TPSLFLGPAR FSNHDCNPNA RLVTKGSEGM EIVAIRDISI GEEITVSYGE NYFGVDNCEC
     LCHTCELSLS NGWSPGGPPE HDSRASTPES TTEHQEKSSS GSEKRKSPPE SPSHPSEDMP
     SKRPRFENIL NLRLELSPPS SPDPIAEPLI TVNGGLRALR SHFASLAGKS ELRHFQKPHS
     NFISASSSSD QTSCSLCPDD EAPTSTRSTS ATSVSDSNVP VKTEPTVEQQ PRASSETASK
     TISGDHGLHV QDVIRDNDES DLSDLSASWE INDREMTAVK REPVKKKKRK RKSSIIPTIE
     HEAPKARTPG DYTKTPKLLA QRYDRWVDCQ TCNAWFVQGD AYLTRKECPR CERHSKLYGY
     CWPKTDREGR NDTEERVMDH RTIHRFLRTE DEARVQRRGR GVSHATSPTP DVSENKTETD
     ASEFGDERRL TRSLRRARSS LHLAI
//