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Protein

Histone-lysine N-methyltransferase

Gene

CPC735_054670

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:CPC735_054670Imported
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)Imported
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000009084 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CPC735_054670.

Interactioni

Protein-protein interaction databases

STRINGi222929.XP_003066242.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 229SETInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
KOiK11429.
OrthoDBiEOG092C4LF0.

Family and domain databases

InterProiView protein in InterPro
IPR025783. Hist-Lys_N-MeTrfase_SET9.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51567. SAM_MT43_SUVAR420_1. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

C5PHU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTPPPKQK GKLTLAQLAA YDDIVTDALV DRAFFWTKIR KNRPKYFAVR
60 70 80 90 100
GVVEDDVTSI LLHDVIVAKD VIKAEESLLN LSGLRKYVEK LKSDKEKEWF
110 120 130 140 150
RRHLRKYIAI YLPDCPFEVT TTNRYTITTH EAALSARKFI RTGDTIKHLS
160 170 180 190 200
GTLVAITPEE EKTLDLTRRD FSIVMSSRKK TPSLFLGPAR FSNHDCNPNA
210 220 230 240 250
RLVTKGSEGM EIVAIRDISI GEEITVSYGE NYFGVDNCEC LCHTCELSLS
260 270 280 290 300
NGWSPGGPPE HDSRASTPES TTEHQEKSSS GSEKRKSPPE SPSHPSEDMP
310 320 330 340 350
SKRPRFENIL NLRLELSPPS SPDPIAEPLI TVNGGLRALR SHFASLAGKS
360 370 380 390 400
ELRHFQKPHS NFISASSSSD QTSCSLCPDD EAPTSTRSTS ATSVSDSNVP
410 420 430 440 450
VKTEPTVEQQ PRASSETASK TISGDHGLHV QDVIRDNDES DLSDLSASWE
460 470 480 490 500
INDREMTAVK REPVKKKKRK RKSSIIPTIE HEAPKARTPG DYTKTPKLLA
510 520 530 540 550
QRYDRWVDCQ TCNAWFVQGD AYLTRKECPR CERHSKLYGY CWPKTDREGR
560 570 580 590 600
NDTEERVMDH RTIHRFLRTE DEARVQRRGR GVSHATSPTP DVSENKTETD
610 620
ASEFGDERRL TRSLRRARSS LHLAI
Length:625
Mass (Da):70,356
Last modified:September 1, 2009 - v1
Checksum:iDBE9C5314AE70B4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000049 Genomic DNA. Translation: EER24097.1.
RefSeqiXP_003066242.1. XM_003066196.1.

Genome annotation databases

EnsemblFungiiEER24097; EER24097; CPC735_054670.
GeneIDi9691712.
KEGGicpw:CPC735_054670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000049 Genomic DNA. Translation: EER24097.1.
RefSeqiXP_003066242.1. XM_003066196.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222929.XP_003066242.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEER24097; EER24097; CPC735_054670.
GeneIDi9691712.
KEGGicpw:CPC735_054670.

Organism-specific databases

EuPathDBiFungiDB:CPC735_054670.

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
KOiK11429.
OrthoDBiEOG092C4LF0.

Family and domain databases

InterProiView protein in InterPro
IPR025783. Hist-Lys_N-MeTrfase_SET9.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51567. SAM_MT43_SUVAR420_1. 1 hit.
PS50280. SET. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC5PHU4_COCP7
AccessioniPrimary (citable) accession number: C5PHU4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: February 15, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.