C5PHM7 (AMPP3_COCP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PEPP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	PEPP
ORF Names:	CPC735_054000

Organism

Coccidioides posadasii (strain C735) (Valley fever fungus) [Complete proteome]

Taxonomic identifier

222929 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides › Coccidioides posadasii

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Probable Xaa-Pro aminopeptidase PEPP		PRO_0000411869
Sites
	Metal binding	265	1	Manganese 2 By similarity
	Metal binding	276	1	Manganese 1 By similarity
	Metal binding	276	1	Manganese 2 By similarity
	Metal binding	399	1	Manganese 1 By similarity
	Metal binding	439	1	Manganese 1 By similarity
	Metal binding	439	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5PHM7 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: 3382417B65392FBE	FASTA	469	52,198
	10 20 30 40 50 60 MDSAVTAVLA GKYPAKQHAR RVAEALKASG HDGSGVIYLE GTKTRMAEDS DEAVPFRQRR 70 80 90 100 110 120 NFYYLSGCEL ADSYVTYNID QDELVLYIPA ADPDEVMWTG LPLSPEEALK KYDVDKVLAS 130 140 150 160 170 180 SEINAHLAHY CTNKETAPKR VYAIPDRVCA ETTFLPFDDT NWDALSNALN QCRKVKDDYE 190 200 210 220 230 240 IALLKRSNEI SALAHLAVMK AAKLAKNERE LEAVFRSTCL SHGSRGQSYG PIVAAGVNGA 250 260 270 280 290 300 TLHYQTNDMD LEDPVTGERP SLLVDAGGEY RLYCSDITRA YPLSGKFSVE ARQIYDIVLD 310 320 330 340 350 360 MQTQCMDMIK PGVAWDDIHA RAHKVAISGL LRLGILRGSE EELFEKRISV AFFPHGLGHY 370 380 390 400 410 420 MGMDTHDVGG NPNHADPNPM FRYLRLRGTL SPSEVVTVEP GVYFCRFIIE PYLSSPELGK 430 440 450 460 YIDSAVLDKY WKVGGVRIED NLVITQDGYL NLTTAPKDPE EVERIVQQG

References

[1]

"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C735.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACFW01000049 Genomic DNA. Translation: EER24030.1.
RefSeq	XP_003066175.1. XM_003066129.1.
UniGene	Cpo.1194.
3D structure databases
ProteinModelPortal	C5PHM7.
ModBase	Search...
Protein-protein interaction databases
STRING	222929.C5PHM7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9691645.
KEGG	cpw:CPC735_054000.
Phylogenomic databases
eggNOG	COG0006.
KO	K14213.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_COCP7

Accession

Primary (citable) accession number: C5PHM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	September 1, 2009
Last modified:	April 3, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program