ID   C5PGW1_COCP7            Unreviewed;       548 AA.
AC   C5PGW1;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   ORFNames=CPC735_051340 {ECO:0000313|EMBL:EER23764.1};
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929 {ECO:0000313|EMBL:EER23764.1, ECO:0000313|Proteomes:UP000009084};
RN   [1] {ECO:0000313|EMBL:EER23764.1, ECO:0000313|Proteomes:UP000009084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- PATHWAY: Amino-acid degradation; L-alanine degradation via transaminase
CC       pathway; pyruvate from L-alanine: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00025708}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. Alanine aminotransferase subfamily.
CC       {ECO:0000256|ARBA:ARBA00025785}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EER23764.1}.
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DR   EMBL; ACFW01000049; EER23764.1; -; Genomic_DNA.
DR   RefSeq; XP_003065909.1; XM_003065863.1.
DR   AlphaFoldDB; C5PGW1; -.
DR   GeneID; 9691379; -.
DR   KEGG; cpw:CPC735_051340; -.
DR   VEuPathDB; FungiDB:CPC735_051340; -.
DR   HOGENOM; CLU_014254_3_0_1; -.
DR   OrthoDB; 5472891at2759; -.
DR   UniPathway; UPA00528; UER00586.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0004021; F:L-alanine:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 1.10.287.1970; -; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR045088; ALAT1/2-like.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11751; ALANINE AMINOTRANSFERASE; 1.
DR   PANTHER; PTHR11751:SF29; ALANINE TRANSAMINASE; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:EER23764.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EER23764.1}.
FT   DOMAIN          162..531
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   548 AA;  60387 MW;  93CFE999E64B7A14 CRC64;
     MPPLPRYTRS FALSFPPRER VLSGARLVPL TRFAAGSASL VLDIARSSSL GPWISSRSYS
     GNKMGSLPVG RLHKGNINPN VLAAKYAVRG ELAVKAEEYR VKLEQELDTL PFDKVIFANI
     GNPQQLDQKP ITFFRQVLSL MEYPPLLENE ETLKSVFGYK QDVIDRAKYL LKDVQSVGAY
     SQSHGSPLVR KSVANFMEKR DGFPADPAHI YLSAGASSGV NTLLNILCAG HDSGVLVPIP
     QYPLYTATLA VLNARCVPYY LDEESNWGTD VDGIKASVAK AKEEGTDVRA IVVINPGNPT
     GACLSPEAVK KVIDLAVDEH LVIIADEVYQ TNIFKGEFTS FKKRLRQLQQ ESPGKYDHVE
     LASLHSVSKG MVGECGHRGG YFELVGFHAD VEEQVYKFIS VMLCPPVIGQ CLVELMVNPP
     KEGDPSYELY QKEYSAISTG LYQRAAALYE AFKQMEGVEC QEPTGAMYLF PSITLPQKAI
     AAAEAAGRHP DEFYSLRLLD ATGVCIVPGS GFGQKPGTYH FRTTFLAPGT DWVNRIVAFH
     KKFMDEFR
//