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Protein

Putative dipeptidase CPC735_015490

Gene

CPC735_015490

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi69 – 691Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi178 – 1781Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi178 – 1781Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei205 – 2051SubstratePROSITE-ProRule annotation
Metal bindingi250 – 2501Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi271 – 2711Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei282 – 2821SubstratePROSITE-ProRule annotation
Binding sitei342 – 3421SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase CPC735_015490 (EC:3.4.13.19)
Gene namesi
ORF Names:CPC735_015490
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 444410Putative dipeptidase CPC735_015490PRO_0000411213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi118 ↔ 207PROSITE-ProRule annotation
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC5PCZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2355.
KOiK01273.
OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5PCZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRTEHNGS WLRNAGSLLS VLACVAVLAS PASATPASAA AAAAPRTDDY
60 70 80 90 100
LKRAERILKF TPLIDGHNDL PNFIRKTTKN QIYEGKIPFE DELPGHTDLK
110 120 130 140 150
RLRKGRVGGQ FWSVYTPCPD PPVPIDNPTW SVRDTLEQID VTKRLIEKYS
160 170 180 190 200
RDLQFCGDAR CARRAFRRGK IASFLGIEGG HQIGNSLGDL RRVYELGVRY
210 220 230 240 250
ITVTHNCDNA FATAQSTVAD GLPDTGLMKP FGIEFVKEMN RLGMLVDLSH
260 270 280 290 300
VSANTMRDTL KVARAPVIFS HSSAYAVSNH LRNVPDDVLK EVAKNNGVVM
310 320 330 340 350
VTFVSRFVNV ENPDAADINT VVDHIFHIAK VAGWDHVGIG GDYDGTVYLP
360 370 380 390 400
KGLEDVSKYP HLIARVLERG ATTQQVRKLV GENILRVWTE VERIAKRLQK
410 420 430 440
TELPNEAYWE GRNWTRPAKR DLNADFEGRS VPLFTSASNG DFCD
Length:444
Mass (Da):49,351
Last modified:August 31, 2009 - v1
Checksum:i139F0A86FA3F1B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000043 Genomic DNA. Translation: EER24951.1.
RefSeqiXP_003067096.1. XM_003067050.1.

Genome annotation databases

GeneIDi9692567.
KEGGicpw:CPC735_015490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000043 Genomic DNA. Translation: EER24951.1.
RefSeqiXP_003067096.1. XM_003067050.1.

3D structure databases

ProteinModelPortaliC5PCZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM19.A01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9692567.
KEGGicpw:CPC735_015490.

Phylogenomic databases

eggNOGiCOG2355.
KOiK01273.
OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735.

Entry informationi

Entry nameiDPEP1_COCP7
AccessioniPrimary (citable) accession number: C5PCZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2011
Last sequence update: August 31, 2009
Last modified: January 6, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.