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C5PCN6 (DPEP2_COCP7) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative dipeptidase CPC735_014430

EC=3.4.13.19
Gene names
ORF Names:CPC735_014430
OrganismCoccidioides posadasii (strain C735) (Valley fever fungus) [Complete proteome]
Taxonomic identifier222929 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes a wide range of dipeptides By similarity.

Catalytic activity

Hydrolysis of dipeptides.

Cofactor

Zinc By similarity.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the peptidase M19 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 464464Putative dipeptidase CPC735_014430
PRO_0000411216

Regions

Transmembrane40 – 5617Helical; Potential

Sites

Metal binding931Zinc 1; catalytic By similarity
Metal binding951Zinc 1; catalytic By similarity
Metal binding2061Zinc 1; catalytic By similarity
Metal binding2061Zinc 2; catalytic By similarity
Metal binding2771Zinc 2; catalytic By similarity
Metal binding2981Zinc 2; catalytic By similarity
Binding site2331Substrate By similarity
Binding site3091Substrate By similarity
Binding site3691Substrate By similarity

Amino acid modifications

Glycosylation3821N-linked (GlcNAc...) Potential
Disulfide bond145 ↔ 235 By similarity

Sequences

Sequence LengthMass (Da)Tools
C5PCN6 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 632DEA67DC973F69

FASTA46451,382
        10         20         30         40         50         60 
MSTMSARDNE KGSARSQPSH AAASEIENVP RPSRQQSWTG TMIKVFIICA CAGIVSKYII 

        70         80         90        100        110        120 
PLDSIFKSVH IDPHDYATRA NRILSTTPLI DGHNDLPYLI RLETKNKIYD HEKLPFRTGL 

       130        140        150        160        170        180 
LSHTDQIKIQ EGKLGGQFWS VFVECATDPN AEIDDPTWAV RDTLEQIDVT KRLVQEYPDL 

       190        200        210        220        230        240 
LEYCESASCA KAAFKRGKVG SFLGIEGGHQ IGNSLASLRQ VYDLGVRYIT VTHNCDNAFA 

       250        260        270        280        290        300 
TAASTVAVGK PDLGLTDFGR EFVKEMNRLG MLVDLSHVSH QTMRDILSVT KAPVMFSHSS 

       310        320        330        340        350        360 
SYALSKHLRN VPDDVLNGVT KNGGVVMVTF VPSFLKVDDP ASATIHDAVD HILHVAKVAG 

       370        380        390        400        410        420 
WDHVGIGSDF DGTADVPEGL ENVSKYPRLI ELLLERGVTD EQARKLIGEN ILRVWSNVEE 

       430        440        450        460 
IAENIRALGE KPNEETWSGR KWTAAIDIPM PFMFKDSADK RKEL 

« Hide

References

[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C735.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ACFW01000043 Genomic DNA. Translation: EER24847.1.
RefSeqXP_003066992.1. XM_003066946.1.
UniGeneCpo.5191.

3D structure databases

ProteinModelPortalC5PCN6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9692463.
KEGGcpw:CPC735_014430.

Phylogenomic databases

eggNOGCOG2355.
KOK01273.
OrthoDBEOG7XM371.

Family and domain databases

InterProIPR000180. Renal_dipep_AS.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERPTHR10443. PTHR10443. 1 hit.
PfamPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPEP2_COCP7
AccessionPrimary (citable) accession number: C5PCN6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries