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C5PCN6

- DPEP2_COCP7

UniProt

C5PCN6 - DPEP2_COCP7

Protein

Putative dipeptidase CPC735_014430

Gene

CPC735_014430

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Hydrolyzes a wide range of dipeptides.By similarity

    Catalytic activityi

    Hydrolysis of dipeptides.PROSITE-ProRule annotation

    Cofactori

    Zinc.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi93 – 931Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi95 – 951Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi206 – 2061Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi206 – 2061Zinc 2; catalyticPROSITE-ProRule annotation
    Binding sitei233 – 2331SubstratePROSITE-ProRule annotation
    Metal bindingi277 – 2771Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi298 – 2981Zinc 2; catalyticPROSITE-ProRule annotation
    Binding sitei309 – 3091SubstratePROSITE-ProRule annotation
    Binding sitei369 – 3691SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-KW
    2. dipeptidyl-peptidase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. metalloexopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative dipeptidase CPC735_014430 (EC:3.4.13.19)
    Gene namesi
    ORF Names:CPC735_014430
    OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
    Taxonomic identifieri222929 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000009084: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 464464Putative dipeptidase CPC735_014430PRO_0000411216Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi145 ↔ 235PROSITE-ProRule annotation
    Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliC5PCN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 5617HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2355.
    KOiK01273.
    OrthoDBiEOG7XM371.

    Family and domain databases

    InterProiIPR000180. Dipep_AS.
    IPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5PCN6-1 [UniParc]FASTAAdd to Basket

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    MSTMSARDNE KGSARSQPSH AAASEIENVP RPSRQQSWTG TMIKVFIICA    50
    CAGIVSKYII PLDSIFKSVH IDPHDYATRA NRILSTTPLI DGHNDLPYLI 100
    RLETKNKIYD HEKLPFRTGL LSHTDQIKIQ EGKLGGQFWS VFVECATDPN 150
    AEIDDPTWAV RDTLEQIDVT KRLVQEYPDL LEYCESASCA KAAFKRGKVG 200
    SFLGIEGGHQ IGNSLASLRQ VYDLGVRYIT VTHNCDNAFA TAASTVAVGK 250
    PDLGLTDFGR EFVKEMNRLG MLVDLSHVSH QTMRDILSVT KAPVMFSHSS 300
    SYALSKHLRN VPDDVLNGVT KNGGVVMVTF VPSFLKVDDP ASATIHDAVD 350
    HILHVAKVAG WDHVGIGSDF DGTADVPEGL ENVSKYPRLI ELLLERGVTD 400
    EQARKLIGEN ILRVWSNVEE IAENIRALGE KPNEETWSGR KWTAAIDIPM 450
    PFMFKDSADK RKEL 464
    Length:464
    Mass (Da):51,382
    Last modified:September 1, 2009 - v1
    Checksum:i632DEA67DC973F69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFW01000043 Genomic DNA. Translation: EER24847.1.
    RefSeqiXP_003066992.1. XM_003066946.1.
    UniGeneiCpo.5191.

    Genome annotation databases

    GeneIDi9692463.
    KEGGicpw:CPC735_014430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFW01000043 Genomic DNA. Translation: EER24847.1 .
    RefSeqi XP_003066992.1. XM_003066946.1.
    UniGenei Cpo.5191.

    3D structure databases

    ProteinModelPortali C5PCN6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9692463.
    KEGGi cpw:CPC735_014430.

    Phylogenomic databases

    eggNOGi COG2355.
    KOi K01273.
    OrthoDBi EOG7XM371.

    Family and domain databases

    InterProi IPR000180. Dipep_AS.
    IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C735.

    Entry informationi

    Entry nameiDPEP2_COCP7
    AccessioniPrimary (citable) accession number: C5PCN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3