C5PCN6 (DPEP2_COCP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative dipeptidase CPC735_014430
EC=3.4.13.19

Gene names

ORF Names:

CPC735_014430

Organism

Coccidioides posadasii (strain C735) (Valley fever fungus) [Complete proteome]

Taxonomic identifier

222929 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides › Coccidioides posadasii

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes a wide range of dipeptides By similarity.
Catalytic activity	Hydrolysis of dipeptides.
Cofactor	Zinc By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the peptidase M19 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Metal-binding Zinc
Molecular function	Dipeptidase Hydrolase Metalloprotease Protease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	dipeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW dipeptidyl-peptidase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Putative dipeptidase CPC735_014430		PRO_0000411216
Regions
	Transmembrane	40 – 56	17	Helical; Potential
Sites
	Metal binding	93	1	Zinc 1; catalytic By similarity
	Metal binding	95	1	Zinc 1; catalytic By similarity
	Metal binding	206	1	Zinc 1; catalytic By similarity
	Metal binding	206	1	Zinc 2; catalytic By similarity
	Metal binding	277	1	Zinc 2; catalytic By similarity
	Metal binding	298	1	Zinc 2; catalytic By similarity
	Binding site	233	1	Substrate By similarity
	Binding site	309	1	Substrate By similarity
	Binding site	369	1	Substrate By similarity
Amino acid modifications
	Glycosylation	382	1	N-linked (GlcNAc...) Potential
	Disulfide bond	145 ↔ 235		By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5PCN6 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: 632DEA67DC973F69	FASTA	464	51,382
	10 20 30 40 50 60 MSTMSARDNE KGSARSQPSH AAASEIENVP RPSRQQSWTG TMIKVFIICA CAGIVSKYII 70 80 90 100 110 120 PLDSIFKSVH IDPHDYATRA NRILSTTPLI DGHNDLPYLI RLETKNKIYD HEKLPFRTGL 130 140 150 160 170 180 LSHTDQIKIQ EGKLGGQFWS VFVECATDPN AEIDDPTWAV RDTLEQIDVT KRLVQEYPDL 190 200 210 220 230 240 LEYCESASCA KAAFKRGKVG SFLGIEGGHQ IGNSLASLRQ VYDLGVRYIT VTHNCDNAFA 250 260 270 280 290 300 TAASTVAVGK PDLGLTDFGR EFVKEMNRLG MLVDLSHVSH QTMRDILSVT KAPVMFSHSS 310 320 330 340 350 360 SYALSKHLRN VPDDVLNGVT KNGGVVMVTF VPSFLKVDDP ASATIHDAVD HILHVAKVAG 370 380 390 400 410 420 WDHVGIGSDF DGTADVPEGL ENVSKYPRLI ELLLERGVTD EQARKLIGEN ILRVWSNVEE 430 440 450 460 IAENIRALGE KPNEETWSGR KWTAAIDIPM PFMFKDSADK RKEL

References

[1]

"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C735.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACFW01000043 Genomic DNA. Translation: EER24847.1.
RefSeq	XP_003066992.1. XM_003066946.1.
UniGene	Cpo.5191.
3D structure databases
ProteinModelPortal	C5PCN6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9692463.
KEGG	cpw:CPC735_014430.
Phylogenomic databases
eggNOG	COG2355.
KO	K01273.
Family and domain databases
InterPro	IPR000180. Pept_M19_AS. IPR008257. Peptidase_M19. [Graphical view]
PANTHER	PTHR10443. PTHR10443. 1 hit.
Pfam	PF01244. Peptidase_M19. 1 hit. [Graphical view]
PROSITE	PS00869. RENAL_DIPEPTIDASE_1. 1 hit. PS51365. RENAL_DIPEPTIDASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPEP2_COCP7

Accession

Primary (citable) accession number: C5PCN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	September 1, 2009
Last modified:	October 3, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program