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Protein

Putative dipeptidase CPC735_014430

Gene

CPC735_014430

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi95 – 951Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi206 – 2061Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi206 – 2061Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei233 – 2331SubstratePROSITE-ProRule annotation
Metal bindingi277 – 2771Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi298 – 2981Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei309 – 3091SubstratePROSITE-ProRule annotation
Binding sitei369 – 3691SubstratePROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase CPC735_014430 (EC:3.4.13.19)
Gene namesi
ORF Names:CPC735_014430
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CPC735_014430.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 5617HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Putative dipeptidase CPC735_014430PRO_0000411216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi145 ↔ 235PROSITE-ProRule annotation
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi222929.XP_003066992.1.

Structurei

3D structure databases

ProteinModelPortaliC5PCN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2355.
KOiK01273.
OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5PCN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTMSARDNE KGSARSQPSH AAASEIENVP RPSRQQSWTG TMIKVFIICA
60 70 80 90 100
CAGIVSKYII PLDSIFKSVH IDPHDYATRA NRILSTTPLI DGHNDLPYLI
110 120 130 140 150
RLETKNKIYD HEKLPFRTGL LSHTDQIKIQ EGKLGGQFWS VFVECATDPN
160 170 180 190 200
AEIDDPTWAV RDTLEQIDVT KRLVQEYPDL LEYCESASCA KAAFKRGKVG
210 220 230 240 250
SFLGIEGGHQ IGNSLASLRQ VYDLGVRYIT VTHNCDNAFA TAASTVAVGK
260 270 280 290 300
PDLGLTDFGR EFVKEMNRLG MLVDLSHVSH QTMRDILSVT KAPVMFSHSS
310 320 330 340 350
SYALSKHLRN VPDDVLNGVT KNGGVVMVTF VPSFLKVDDP ASATIHDAVD
360 370 380 390 400
HILHVAKVAG WDHVGIGSDF DGTADVPEGL ENVSKYPRLI ELLLERGVTD
410 420 430 440 450
EQARKLIGEN ILRVWSNVEE IAENIRALGE KPNEETWSGR KWTAAIDIPM
460
PFMFKDSADK RKEL
Length:464
Mass (Da):51,382
Last modified:September 1, 2009 - v1
Checksum:i632DEA67DC973F69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000043 Genomic DNA. Translation: EER24847.1.
RefSeqiXP_003066992.1. XM_003066946.1.
UniGeneiCpo.5191.

Genome annotation databases

GeneIDi9692463.
KEGGicpw:CPC735_014430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000043 Genomic DNA. Translation: EER24847.1.
RefSeqiXP_003066992.1. XM_003066946.1.
UniGeneiCpo.5191.

3D structure databases

ProteinModelPortaliC5PCN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222929.XP_003066992.1.

Protein family/group databases

MEROPSiM19.A01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9692463.
KEGGicpw:CPC735_014430.

Organism-specific databases

EuPathDBiFungiDB:CPC735_014430.

Phylogenomic databases

eggNOGiCOG2355.
KOiK01273.
OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735.

Entry informationi

Entry nameiDPEP2_COCP7
AccessioniPrimary (citable) accession number: C5PCN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 1, 2009
Last modified: June 24, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.