C5PAH2 (AMPP2_COCP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase CPC735_009100
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

CPC735_009100

Organism

Coccidioides posadasii (strain C735) (Valley fever fungus) [Complete proteome]

Taxonomic identifier

222929 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides › Coccidioides posadasii

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Probable Xaa-Pro aminopeptidase CPC735_009100		PRO_0000411832
Sites
	Metal binding	275	1	Manganese 2 By similarity
	Metal binding	286	1	Manganese 1 By similarity
	Metal binding	286	1	Manganese 2 By similarity
	Metal binding	421	1	Manganese 1 By similarity
	Metal binding	460	1	Manganese 1 By similarity
	Metal binding	460	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5PAH2 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: C26B4C0FBE5FAF02	FASTA	487	54,980
	10 20 30 40 50 60 MAGSNTLSSS EHGDDPRGHS YSIHIQTRGT TLDKYPAKQH ARNVARQLGL TDGLIYLMSQ 70 80 90 100 110 120 STRTLEDSDQ PQPFRQRRYF FYLSGVDEPD CHLTFDIKSD ILTLYVPHYD LRKAIWVGPT 130 140 150 160 170 180 LRPSEAMMRY DLNAAKTYDE LSKNIRTWAS KRMSPVIYIL HEGQKPNINA HFLAFNHEDL 190 200 210 220 230 240 LPAMDACREI KDEHEIDLIR RANEISASAH IEVLLGIRNM QNEAEIHGKF LDTCVSQGAR 250 260 270 280 290 300 NQSYEIIAAS GENAAILHYT KNNEPLDDRQ LVCLDAGAEW NCYASDVTRT FPRRPYWPSC 310 320 330 340 350 360 ESANIYSVVQ RMQEECINGL KEGVRYLDLH ILAHRIAIEE LLSLGILKGG STEEILQSGA 370 380 390 400 410 420 SLVFFPHGLG HHVGLEVHDV SPTPLMAFSL DKYKGLPLLS CRPPCTLSAP YLKAGMVVTV 430 440 450 460 470 480 EPGIYFSRPA LKDARRKPLS KYIDMDVVQK YIPVGGVRIE DDILVTRDGF ENLTKAPKGR EMLKTIR

References

[1]

"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C735.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACFW01000030 Genomic DNA. Translation: EER26734.1.
RefSeq	XP_003068879.1. XM_003068833.1.
UniGene	Cpo.1661.
3D structure databases
ProteinModelPortal	C5PAH2.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9694362.
KEGG	cpw:CPC735_009100.
Phylogenomic databases
eggNOG	COG0006.
KO	K14213.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_COCP7

Accession

Primary (citable) accession number: C5PAH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	September 1, 2009
Last modified:	March 6, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program