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C5P8Q4

- MAP2_COCP7

UniProt

C5P8Q4 - MAP2_COCP7

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Protein
Methionine aminopeptidase 2
Gene
CPC735_002850
Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei202 – 2021Substrate By similarity
Metal bindingi222 – 2221Divalent metal cation 1 By similarity
Metal bindingi233 – 2331Divalent metal cation 1 By similarity
Metal bindingi233 – 2331Divalent metal cation 2; catalytic By similarity
Metal bindingi302 – 3021Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei310 – 3101Substrate By similarity
Metal bindingi338 – 3381Divalent metal cation 2; catalytic By similarity
Metal bindingi433 – 4331Divalent metal cation 1 By similarity
Metal bindingi433 – 4331Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2 (EC:3.4.11.18)
Short name:
MAP 2
Short name:
MetAP 2
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:CPC735_002850
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Methionine aminopeptidase 2UniRule annotation
PRO_0000407650Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi222929.C5P8Q4.

Structurei

3D structure databases

ProteinModelPortaliC5P8Q4.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 7917Lys-richUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0024.
KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5P8Q4-1 [UniParc]FASTAAdd to Basket

« Hide

MAVQALPEIN KLSVSEEGAA NAAAKGQAAQ GTAGNDDAEN DESDEDKEDE    50
QEVADGAAAA GGKKKKKKTK KKKKKGTAKV QSDPPRVPLS TLFPNNNYPE 100
GEIVEYKDDN AYRTTNEEKR YLDRMNNDFL TDYRKSAEIH RQVRQYAQKE 150
LLKPGRSLTE IAEGIEDSVR ALTGHMGLEE GDSLVAGMGF PTGLNINHCA 200
AHYSPNAGNK MVLQYGDVMK VDFGVHVNGR IVDSAFTVAF DPVYDNLLNA 250
VKDATNTGIR EAGIDVRMSD IGAAIQETME SYEVEINGTI YPVKAIRNLN 300
GHTIGHYLIH GGSTGKSVPI VKGGDQTKME EGETYAIETF GSTGKGFVRD 350
DMEVSHYAKV PDAPNVPLRL SSAKNLLNVI TKNFGTLPFC RRYLDRLGQE 400
KYLLGLNNLV SSGLVDAYPP LVDVKGSYTA QFEHTILLRP NVKEVITRGD 450
DY 452
Length:452
Mass (Da):49,394
Last modified:May 3, 2011 - v2
Checksum:i9E4A3B36E989C61F
GO

Sequence cautioni

The sequence EER26116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACFW01000030 Genomic DNA. Translation: EER26116.1. Different initiation.
RefSeqiXP_003068261.1. XM_003068215.1.
UniGeneiCpo.1088.

Genome annotation databases

GeneIDi9693744.
KEGGicpw:CPC735_002850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACFW01000030 Genomic DNA. Translation: EER26116.1 . Different initiation.
RefSeqi XP_003068261.1. XM_003068215.1.
UniGenei Cpo.1088.

3D structure databases

ProteinModelPortali C5P8Q4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 222929.C5P8Q4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9693744.
KEGGi cpw:CPC735_002850.

Phylogenomic databases

eggNOGi COG0024.
KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735.

Entry informationi

Entry nameiMAP2_COCP7
AccessioniPrimary (citable) accession number: C5P8Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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