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Protein

Histone-lysine N-methyltransferase

Gene

CPC735_027520

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
ORF Names:CPC735_027520Imported
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)Imported
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi222929.C5P7L6.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG2940.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5P7L6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGHDDEEAR IETVKDAVTD MKLERQSSTE SIAPNGILDT ITPKDEPNGH
60 70 80 90 100
LSSKPSTPSL KPPKSRSRSS NSLAKDEVPE EKVGGDITIK QEPGQPPKLA
110 120 130 140 150
RSASQKLPAR AAPLFTDLPD KTTEATSTFQ LMEVCTYANK YLGYTEHAMD
160 170 180 190 200
CDCAEEWDAA TCRNTACGED SDCINRATKM ECFGDCGCGD SCQNQRFQRR
210 220 230 240 250
EYAKVSVIKT EKKGYGLRAD CDLRPNEFIF EYIGEVINEP QFRRRMIQYD
260 270 280 290 300
EEGIKHFYFM SLNKGEFVDA TKKGNLGRFC NHSCNPNCYV DKWVVGEKLR
310 320 330 340 350
MGIFAERYIK AGEELVFNYN VDRYGADPQP CYCGEPNCTG FIGGKTQTER
360 370 380 390 400
ATKLSHATIE ALGIDDPDGW DTAVARRPRK KKTGEDDEEY VDSLQPKSLD
410 420 430 440 450
ENGVTKVMAA LMQCKEKWIA VKLLGRIQRC EDERVRHRVV RMHGYQILNS
460 470 480 490 500
QLNTWKDDFN VVLQILDILD KFPRLTRNKI IDSKIEGTVS PLQECDDERV
510 520 530 540 550
AEKAKALLEI WSALEVGYRI PRMKRDPAAV NNTPTANHYE RRETAKDDRK
560 570 580 590 600
PNSSKSRSSS RSRSRSVDVT RNAPRGPAAL TRGGGKGHMH SYRPGQRPFR
610 620 630 640 650
RPFNPLPKGW FAAESNGRTY YYSATGETTW SRPTAPAVQP PPPPKRESKE
660 670 680 690 700
KTLQDIIDGI MNAKENTPKA KDKSATPATP ADAKIPEKKE HKEKWRSYSE
710 720 730 740 750
EKQKKLYENT LFPHVKYIVD KFKHKLPKDD LKRYAKEVAK KLVNSDFKNN
760 770 780 790 800
RVEDPTKISE KQIKQVKKYC KEYFDKAVAK HRAYEEKKAE RKSKGSVKAT
810 820 830 840 850
TSATIDKAET TSTKAPPQFD GAAETGDGDS DVQLSDAEYE DGQEGSSHHS
860 870 880 890 900
GLKRKRTDDE DFENDHENGG VSPTKRQRSA SLPIIPPPPP PMSPSNLVLD
910 920 930 940 950
DGSREALKRQ RTEGAEDDEY GDSTISSGKR QRSETPPPPP PPPPPADIPP
960 970 980 990 1000
ENIESENEND KDQEELQDYD VQEAKWGKED NIAIQSPSHS PFPAQSISNH
1010
SNTAHETDSH S
Length:1,011
Mass (Da):113,732
Last modified:September 1, 2009 - v1
Checksum:i858BFFAD67590DD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000025 Genomic DNA. Translation: EER27416.1.
RefSeqiXP_003069561.1. XM_003069515.1.
UniGeneiCpo.2947.

Genome annotation databases

GeneIDi9695056.
KEGGicpw:CPC735_027520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000025 Genomic DNA. Translation: EER27416.1.
RefSeqiXP_003069561.1. XM_003069515.1.
UniGeneiCpo.2947.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222929.C5P7L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9695056.
KEGGicpw:CPC735_027520.

Phylogenomic databases

eggNOGiCOG2940.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735Imported.

Entry informationi

Entry nameiC5P7L6_COCP7
AccessioniPrimary (citable) accession number: C5P7L6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: February 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.