Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase

Gene

CPC735_027520

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:CPC735_027520Imported
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)Imported
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000009084 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CPC735_027520.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi222929.XP_003069561.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 201AWSInterPro annotationAdd BLAST56
Domaini203 – 320SETInterPro annotationAdd BLAST118
Domaini327 – 343Post-SETInterPro annotationAdd BLAST17
Domaini604 – 635WWInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4442. Eukaryota.
COG2940. LUCA.
KOiK11423.
OrthoDBiEOG092C3T9B.

Family and domain databases

CDDicd00201. WW. 1 hit.
InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF08711. Med26. 1 hit.
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C5P7L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGHDDEEAR IETVKDAVTD MKLERQSSTE SIAPNGILDT ITPKDEPNGH
60 70 80 90 100
LSSKPSTPSL KPPKSRSRSS NSLAKDEVPE EKVGGDITIK QEPGQPPKLA
110 120 130 140 150
RSASQKLPAR AAPLFTDLPD KTTEATSTFQ LMEVCTYANK YLGYTEHAMD
160 170 180 190 200
CDCAEEWDAA TCRNTACGED SDCINRATKM ECFGDCGCGD SCQNQRFQRR
210 220 230 240 250
EYAKVSVIKT EKKGYGLRAD CDLRPNEFIF EYIGEVINEP QFRRRMIQYD
260 270 280 290 300
EEGIKHFYFM SLNKGEFVDA TKKGNLGRFC NHSCNPNCYV DKWVVGEKLR
310 320 330 340 350
MGIFAERYIK AGEELVFNYN VDRYGADPQP CYCGEPNCTG FIGGKTQTER
360 370 380 390 400
ATKLSHATIE ALGIDDPDGW DTAVARRPRK KKTGEDDEEY VDSLQPKSLD
410 420 430 440 450
ENGVTKVMAA LMQCKEKWIA VKLLGRIQRC EDERVRHRVV RMHGYQILNS
460 470 480 490 500
QLNTWKDDFN VVLQILDILD KFPRLTRNKI IDSKIEGTVS PLQECDDERV
510 520 530 540 550
AEKAKALLEI WSALEVGYRI PRMKRDPAAV NNTPTANHYE RRETAKDDRK
560 570 580 590 600
PNSSKSRSSS RSRSRSVDVT RNAPRGPAAL TRGGGKGHMH SYRPGQRPFR
610 620 630 640 650
RPFNPLPKGW FAAESNGRTY YYSATGETTW SRPTAPAVQP PPPPKRESKE
660 670 680 690 700
KTLQDIIDGI MNAKENTPKA KDKSATPATP ADAKIPEKKE HKEKWRSYSE
710 720 730 740 750
EKQKKLYENT LFPHVKYIVD KFKHKLPKDD LKRYAKEVAK KLVNSDFKNN
760 770 780 790 800
RVEDPTKISE KQIKQVKKYC KEYFDKAVAK HRAYEEKKAE RKSKGSVKAT
810 820 830 840 850
TSATIDKAET TSTKAPPQFD GAAETGDGDS DVQLSDAEYE DGQEGSSHHS
860 870 880 890 900
GLKRKRTDDE DFENDHENGG VSPTKRQRSA SLPIIPPPPP PMSPSNLVLD
910 920 930 940 950
DGSREALKRQ RTEGAEDDEY GDSTISSGKR QRSETPPPPP PPPPPADIPP
960 970 980 990 1000
ENIESENEND KDQEELQDYD VQEAKWGKED NIAIQSPSHS PFPAQSISNH
1010
SNTAHETDSH S
Length:1,011
Mass (Da):113,732
Last modified:September 1, 2009 - v1
Checksum:i858BFFAD67590DD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000025 Genomic DNA. Translation: EER27416.1.
RefSeqiXP_003069561.1. XM_003069515.1.
UniGeneiCpo.2947.

Genome annotation databases

EnsemblFungiiEER27416; EER27416; CPC735_027520.
GeneIDi9695056.
KEGGicpw:CPC735_027520.

Similar proteinsi

Entry informationi

Entry nameiC5P7L6_COCP7
AccessioniPrimary (citable) accession number: C5P7L6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: August 30, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported