C5P7J2 (AMPP1_COCP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	CPC735_027280

Organism

Coccidioides posadasii (strain C735) (Valley fever fungus) [Complete proteome]

Taxonomic identifier

222929 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides › Coccidioides posadasii

Protein attributes

Sequence length	651 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 651	651	Probable Xaa-Pro aminopeptidase P		PRO_0000411787
Sites
	Metal binding	448	1	Manganese 2 By similarity
	Metal binding	459	1	Manganese 1 By similarity
	Metal binding	459	1	Manganese 2 By similarity
	Metal binding	557	1	Manganese 1 By similarity
	Metal binding	571	1	Manganese 1 By similarity
	Metal binding	571	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5P7J2 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: AEBFA0DB692CD098	FASTA	651	72,466
	10 20 30 40 50 60 MTLFRSSLRL RLPVTLLSPP PIHKHSRLFS ASHRLFTAAE MPVDTSQRLA KLRELMKERH 70 80 90 100 110 120 VDVYLIPSED SHQSEYIAPC DARRAFISGF TGSAGCAIVS MSKAALSTDG RYFNQAAKQL 130 140 150 160 170 180 DENWLLLKRG MENVPTWQEW TAEQAEGGKV VGVDPSLITA AEARKLSDTI KNTGGSLVGV 190 200 210 220 230 240 PDNLVDLVWG GDRPARPREK VMVHPIEFAG QSFEEKITDL RKELTKKKRA GMVISMLDEI 250 260 270 280 290 300 AWLYNLRGAD IPFNPVFFAY AIVTHSTAEL FVDEAKLTQA VKEHLGDKVA LRPYESIFES 310 320 330 340 350 360 LKLLSQAAAS NGDEGHQKFL LSDKASWSLN LALGGEEKVE EVRSPIADAK AVKNAVELEG 370 380 390 400 410 420 TRACHIRDGA ALTEYFAWLE NELINKKTVL NEVDASDKLA QIRSKHKDFV GLSFDTISST 430 440 450 460 470 480 GPNAAIIHYR AERGNCPNID PNAVYLCDSG AQYLDGTTDT TRTLHFGKPT EMEKKAYTLV 490 500 510 520 530 540 LKGLISIDTA VFPKGTTGYA IDAFARQHLW RNGLDYLHGT GHGVGSYLNV HEGPMGIGTR 550 560 570 580 590 600 VQYAETPITA GNVLSDEPGY YEDGNFGIRI ENIVVAKEVK TPHKFGDKPW IGFEHVTMTP 610 620 630 640 650 LCQNLMDTSL LTAEEKKWVN DYHTEVWEKT KGFFNNDELT RNWLKRETQP I

References

[1]

"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C735.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACFW01000025 Genomic DNA. Translation: EER27392.1.
RefSeq	XP_003069537.1. XM_003069491.1.
UniGene	Cpo.2647.
3D structure databases
ProteinModelPortal	C5P7J2.
ModBase	Search...
Protein-protein interaction databases
STRING	222929.C5P7J2.
Protein family/group databases
MEROPS	M24.009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9695032.
KEGG	cpw:CPC735_027280.
Phylogenomic databases
eggNOG	COG0006.
KO	K01262.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_COCP7

Accession

Primary (citable) accession number: C5P7J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	September 1, 2009
Last modified:	April 3, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program