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Protein

Mitogen-activated protein kinase

Gene

CPC735_025180

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
ORF Names:CPC735_025180Imported
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)Imported
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CPC735_025180.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi222929.XP_003069327.1.

Structurei

3D structure databases

ProteinModelPortaliC5P6Y2.
SMRiC5P6Y2. Positions 3-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0515.
KOiK04441.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5P6Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFVRAQIF GTTFEITTRY TDLQPVGMGA FGLVCSARDQ LTNQAVAVKK
60 70 80 90 100
IMKPFSTPVL AKRTYRELKL LKHLRHENVI SLSDIFISPL EDIYFVTELL
110 120 130 140 150
GTDLHRLLTS RPLEKQFIQY FLYQILRGLK YVHSAGVVHR DLKPSNILIN
160 170 180 190 200
ENCDLKICDF GLARVQDPQM TGYVSTRYYR APEIMLTWQK YDVEVDVWSA
210 220 230 240 250
GCIFAEMLSG RPLFPGKDHV NQFSIITELL GSPPDDVIKT ICSANTLQFV
260 270 280 290 300
QSLPKRERQP LSEKFKGAEP LAVDLLERML VFDPKKRITA AEGLAHEYLA
310 320 330 340 350
PYHDPTDEPV AETQFDWSFN DAELPIDSWK VMMYSEILDY HNVDQDSQGI
360
HGTPLNTEAQ RVPM
Length:364
Mass (Da):41,608
Last modified:September 1, 2009 - v1
Checksum:iCB4A1CFAD2137BF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000025 Genomic DNA. Translation: EER27182.1.
RefSeqiXP_003069327.1. XM_003069281.1.
UniGeneiCpo.2625.

Genome annotation databases

GeneIDi9694822.
KEGGicpw:CPC735_025180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000025 Genomic DNA. Translation: EER27182.1.
RefSeqiXP_003069327.1. XM_003069281.1.
UniGeneiCpo.2625.

3D structure databases

ProteinModelPortaliC5P6Y2.
SMRiC5P6Y2. Positions 3-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222929.XP_003069327.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9694822.
KEGGicpw:CPC735_025180.

Organism-specific databases

EuPathDBiFungiDB:CPC735_025180.

Phylogenomic databases

eggNOGiCOG0515.
KOiK04441.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735Imported.

Entry informationi

Entry nameiC5P6Y2_COCP7
AccessioniPrimary (citable) accession number: C5P6Y2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: June 24, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.