ID   C5P6M8_COCP7            Unreviewed;       619 AA.
AC   C5P6M8;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=V-type ATPase, C subunit family protein {ECO:0000313|EMBL:EER27078.1};
GN   ORFNames=CPC735_024140 {ECO:0000313|EMBL:EER27078.1};
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929 {ECO:0000313|EMBL:EER27078.1, ECO:0000313|Proteomes:UP000009084};
RN   [1] {ECO:0000313|EMBL:EER27078.1, ECO:0000313|Proteomes:UP000009084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC       {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004128}.
CC   -!- SIMILARITY: Belongs to the V-ATPase proteolipid subunit family.
CC       {ECO:0000256|ARBA:ARBA00007296}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EER27078.1}.
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DR   EMBL; ACFW01000025; EER27078.1; -; Genomic_DNA.
DR   RefSeq; XP_003069223.1; XM_003069177.1.
DR   AlphaFoldDB; C5P6M8; -.
DR   SMR; C5P6M8; -.
DR   GeneID; 9694718; -.
DR   KEGG; cpw:CPC735_024140; -.
DR   VEuPathDB; FungiDB:CPC735_024140; -.
DR   HOGENOM; CLU_441445_0_0_1; -.
DR   OrthoDB; 2723686at2759; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   CDD; cd18175; ATP-synt_Vo_c_ATP6C_rpt1; 1.
DR   CDD; cd18176; ATP-synt_Vo_c_ATP6C_rpt2; 1.
DR   Gene3D; 1.20.120.610; lithium bound rotor ring of v- atpase; 1.
DR   InterPro; IPR002379; ATPase_proteolipid_c-like_dom.
DR   InterPro; IPR000245; ATPase_proteolipid_csu.
DR   InterPro; IPR011555; ATPase_proteolipid_su_C_euk.
DR   InterPro; IPR035921; F/V-ATP_Csub_sf.
DR   NCBIfam; TIGR01100; V_ATP_synt_C; 1.
DR   PANTHER; PTHR10263:SF5; V-TYPE PROTON ATPASE 16 KDA PROTEOLIPID SUBUNIT C; 1.
DR   PANTHER; PTHR10263; V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT; 1.
DR   Pfam; PF00137; ATP-synt_C; 2.
DR   PRINTS; PR00122; VACATPASE.
DR   SUPFAM; SSF81333; F1F0 ATP synthase subunit C; 2.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        514..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        547..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        584..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          476..534
FT                   /note="V-ATPase proteolipid subunit C-like"
FT                   /evidence="ECO:0000259|Pfam:PF00137"
FT   DOMAIN          551..610
FT                   /note="V-ATPase proteolipid subunit C-like"
FT                   /evidence="ECO:0000259|Pfam:PF00137"
SQ   SEQUENCE   619 AA;  66120 MW;  182190B633E47592 CRC64;
     MGHIFQDALR TDEEIKDIYS ISAVVDKLPI PAGLVSSARS ASPEDSPAFE KEGCEGISLL
     IADQESLSGD IVRPMRRRDV SMPEIEPTIT YAMTYEQDGG EKVSTEVGVR IANTIFVTGT
     PRTMLASRWR FDEEIGKLKP KETKDLVICR IESNANSSVT PFIPLHPVTQ PRKVITSMGN
     VLSQISTGNG STKSAPASAE LEKALPAYID KHQLQNRRLA VWALVKPEEL HCSSEASPEA
     SGTDDVSNAI KKSARLHRLM SGGGGWGKKQ GLLSLDPEYS YQEEHSSGHR RPINELFERN
     TIEPDIEQTA FDSFPSFMEF NNGKLVTPLS EAAKPGDTVQ FFVAPLDTAV PIHSPLGHTN
     SSQGSQPAEV AERFIFGVIP SVETASVPVA GLENDLRSST QVSDKHLIVV PNHFGALSEN
     GITFTTFEQD SLTGADERAL EVSGTKIDVP GSRISIRTQF KSTLVHNLPR CLQTSGCSSA
     IIFTCFGAAY GTAKAGVGVC STAVLRPDLI VKNIVPIVMA GIIGIYGLVV SVLIANDLGQ
     NKSLYTGFIQ LGAGLSVGLA GLAAGFAIGI VGDAGVRGTA QQPRLFVGMI LILIFAEVLG
     LYGLIVALLM NSRASGAEC
//