ID   C5P6J9_COCP7            Unreviewed;       505 AA.
AC   C5P6J9;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Aldehyde dehydrogenase, putative {ECO:0000313|EMBL:EER27049.1};
DE            EC=1.2.1.3 {ECO:0000313|EMBL:EER27049.1};
GN   ORFNames=CPC735_023850 {ECO:0000313|EMBL:EER27049.1};
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929 {ECO:0000313|EMBL:EER27049.1, ECO:0000313|Proteomes:UP000009084};
RN   [1] {ECO:0000313|EMBL:EER27049.1, ECO:0000313|Proteomes:UP000009084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024149};
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EER27049.1}.
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DR   EMBL; ACFW01000025; EER27049.1; -; Genomic_DNA.
DR   RefSeq; XP_003069194.1; XM_003069148.1.
DR   AlphaFoldDB; C5P6J9; -.
DR   GeneID; 9694689; -.
DR   KEGG; cpw:CPC735_023850; -.
DR   VEuPathDB; FungiDB:CPC735_023850; -.
DR   HOGENOM; CLU_005391_0_1_1; -.
DR   OrthoDB; 216092at2759; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   CDD; cd07091; ALDH_F1-2_Ald2-like; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR11699:SF272; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:EER27049.1}.
FT   DOMAIN          42..495
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
SQ   SEQUENCE   505 AA;  53380 MW;  B3A355B6E2828213 CRC64;
     MRTKSSVGIM AAQTVTLQGA EGRSIEIPTG LFINNEFVPS LTGTTLDTTN PANGDLLATI
     AAASEEDINA AVQSAKDAFY TTWKATPPTT RQSLMLKLAD LIERDVDEFA NLEALDGGIL
     LSGSKGMHVP HSVETLRYFA GWADKIDGKS IAIPSGIAYT HREPLGVCAA IVPWNAPLIV
     TMWKLAPCIA AGNTLVLKTS ELTPLYGIKL AALIKEAGFP AGVVNIVTGL GAVAGRALSE
     HMDVRKIAFT GSTLTGRAIM KAAASSNLKK VTLELGGKGP TIIFDDADLQ NAVFWATLGI
     TANNGQICVA GSRIYVQEGI YEKFIAAFSA ASTKAVAGDP LLSNTTKGPI VSADQHSKIM
     GYIKKGQDEG ARLLHGGGQP APGYIENTAF VDVNEDMTIM REEIFGPVAA ISKFKTESEA
     IQKANNTEYG LSSAIFTNNV SRADRVSRAL ESGQVTVNSW GMVHANVPFG GIKMSGFGKD
     MGEESLDGWT GTKTIKYHTL PEVPN
//