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C5P635 (KEX1_COCP7) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:CPC735_035110
OrganismCoccidioides posadasii (strain C735) (Valley fever fungus) [Complete proteome]
Taxonomic identifier222929 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length641 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 641607Pheromone-processing carboxypeptidase KEX1
PRO_0000411914

Regions

Topological domain35 – 522488Lumenal Potential
Transmembrane523 – 54321Helical; Potential
Topological domain544 – 64198Cytoplasmic Potential
Compositional bias637 – 6415Poly-Ser

Sites

Active site1881 By similarity
Active site3891 By similarity
Active site4511 By similarity

Amino acid modifications

Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation4401N-linked (GlcNAc...) Potential
Glycosylation4481N-linked (GlcNAc...) Potential
Glycosylation5001N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5P635 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: DF5FE3A9BC27E772

FASTA64171,773
        10         20         30         40         50         60 
MRSTSTFTRT PAFLLHTLAR WLLVWGVLGS SVVAEKKCAS NYYVRSLPGQ PDGPLLKMHA 

        70         80         90        100        110        120 
GHVEVDHKNN GNLFFWHFQN RHIANRQRTV IWLNGGPGCS SMDGALMEIG PYRLKDDHTL 

       130        140        150        160        170        180 
IYNEGSWDEF ANILFVDQPV GTGFSYVNTN SYIHELDEMA SHFVTFLEKW FELFPEYEHD 

       190        200        210        220        230        240 
DLYFAGESYA GQYIPYIAKA ILDRNKNTTT QAQSRLWNLK GLLIGNGWIS PVEQYQAYLT 

       250        260        270        280        290        300 
YAYKENLIQS GTDAAKRVER AHSECISELD SGGKDRIHAG ACEKVLSAVL EVTRENGKCI 

       310        320        330        340        350        360 
NMYDIRLRDE FPSCGMNWPP DLKHITPYLR RDDVISALHV NDDKRTGWRE CTGAVSSNFN 

       370        380        390        400        410        420 
ARNSKPSVQL LPEILESGIP ITLFSGAKDF ICNHIGTEQF IHNMQWSGGT GFELSPGVWA 

       430        440        450        460        470        480 
PRHDWTFEGE AAGYYQEARN LTYVLFYNAS HMVPFDFGRR SRDMLDRFLG VDITSIGGNP 

       490        500        510        520        530        540 
ADSRIDGEKG ALTSVGNHPN STTAEQREKE KLKAATWAAY YKSGEVALVV VAIAAAVWGF 

       550        560        570        580        590        600 
FIWRSRRQRQ GSGYRGIYPN LNGLSSGSFS GFRNKRSSHD DIEAAADFDA SELDTLRGTD 

       610        620        630        640 
DRSRGANGHG SVGGDSEDED EKFGAQKESY HPSNMPSSSS S 

« Hide

References

[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C735.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ACFW01000025 Genomic DNA. Translation: EER28175.1.
RefSeqXP_003070320.1. XM_003070274.1.
UniGeneCpo.4836.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING222929.C5P635.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9695815.
KEGGcpw:CPC735_035110.

Phylogenomic databases

eggNOGCOG2939.
KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKEX1_COCP7
AccessionPrimary (citable) accession number: C5P635
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries