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C5P635

- KEX1_COCP7

UniProt

C5P635 - KEX1_COCP7

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei188 – 1881By similarity
    Active sitei389 – 3891By similarity
    Active sitei451 – 4511By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:CPC735_035110
    OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
    Taxonomic identifieri222929 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000009084: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 641607Pheromone-processing carboxypeptidase KEX1PRO_0000411914Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi222929.C5P635.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 522488LumenalSequence AnalysisAdd
    BLAST
    Topological domaini544 – 64198CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei523 – 54321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi637 – 6415Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2939.
    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C5P635-1 [UniParc]FASTAAdd to Basket

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    MRSTSTFTRT PAFLLHTLAR WLLVWGVLGS SVVAEKKCAS NYYVRSLPGQ    50
    PDGPLLKMHA GHVEVDHKNN GNLFFWHFQN RHIANRQRTV IWLNGGPGCS 100
    SMDGALMEIG PYRLKDDHTL IYNEGSWDEF ANILFVDQPV GTGFSYVNTN 150
    SYIHELDEMA SHFVTFLEKW FELFPEYEHD DLYFAGESYA GQYIPYIAKA 200
    ILDRNKNTTT QAQSRLWNLK GLLIGNGWIS PVEQYQAYLT YAYKENLIQS 250
    GTDAAKRVER AHSECISELD SGGKDRIHAG ACEKVLSAVL EVTRENGKCI 300
    NMYDIRLRDE FPSCGMNWPP DLKHITPYLR RDDVISALHV NDDKRTGWRE 350
    CTGAVSSNFN ARNSKPSVQL LPEILESGIP ITLFSGAKDF ICNHIGTEQF 400
    IHNMQWSGGT GFELSPGVWA PRHDWTFEGE AAGYYQEARN LTYVLFYNAS 450
    HMVPFDFGRR SRDMLDRFLG VDITSIGGNP ADSRIDGEKG ALTSVGNHPN 500
    STTAEQREKE KLKAATWAAY YKSGEVALVV VAIAAAVWGF FIWRSRRQRQ 550
    GSGYRGIYPN LNGLSSGSFS GFRNKRSSHD DIEAAADFDA SELDTLRGTD 600
    DRSRGANGHG SVGGDSEDED EKFGAQKESY HPSNMPSSSS S 641
    Length:641
    Mass (Da):71,773
    Last modified:September 1, 2009 - v1
    Checksum:iDF5FE3A9BC27E772
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFW01000025 Genomic DNA. Translation: EER28175.1.
    RefSeqiXP_003070320.1. XM_003070274.1.
    UniGeneiCpo.4836.

    Genome annotation databases

    GeneIDi9695815.
    KEGGicpw:CPC735_035110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFW01000025 Genomic DNA. Translation: EER28175.1 .
    RefSeqi XP_003070320.1. XM_003070274.1.
    UniGenei Cpo.4836.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 222929.C5P635.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9695815.
    KEGGi cpw:CPC735_035110.

    Phylogenomic databases

    eggNOGi COG2939.
    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C735.

    Entry informationi

    Entry nameiKEX1_COCP7
    AccessioniPrimary (citable) accession number: C5P635
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3