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C5P334

- DAPB_COCP7

UniProt

C5P334 - DAPB_COCP7

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei754 – 7541Charge relay systemBy similarity
    Active sitei831 – 8311Charge relay systemBy similarity
    Active sitei864 – 8641Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:CPC735_039860
    OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
    Taxonomic identifieri222929 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000009084: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 917917Probable dipeptidyl-aminopeptidase BPRO_0000412142Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi222929.C5P334.

    Structurei

    3D structure databases

    ProteinModelPortaliC5P334.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 917806VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei91 – 11121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1506.
    KOiK01282.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5P334-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVEKRINDE EMQPLAERDD KSRDSIDSTS TASISLALLG GANGSAHGSR    50
    AARTRKSENQ EKYHDDEEEG DLEEGFVPPA GGWSAPRKVS VIFTLIVTLC 100
    IAGWLVAFFV LLGRHKDSSK DAAVSQGESN IIPGIYSGGR GGKKLDLDGV 150
    LFGNWSPKSH DISWFPGPNG ADGLLLEQGG DRNKAYLRVE DIRSRNPGNK 200
    ADDTIVLMRE SSFMVGKRLV RPSKVWPSPD LKTVLVMSDQ RKNWRHSYTG 250
    NYWIFDVETQ TGEPLDPESL DGGIQLASWS PNSDAIVFTR KNNMFIRRLP 300
    SKNVKQITTD GGTNLFYGIP DWVYEEEVFS DSSATWWDGD GKFVAFLRTN 350
    ESRVPEYPVQ YFIPNTNKPS RPSEENYPDI RKIKYPKAGA PNPVVNIQFF 400
    DVEKEEVFSV DVKDDLPDDD RLVIGVTWAS NGNVLVRETN RESDRLSVVL 450
    IDAAKRAGKV VRSRNFSSLD GGWVEPSQTT HFVPADPKNG RPHDGYIETI 500
    PHDGFEHLAY FTPMDNSEPT VLTSGDWEVV DAPSAVDLKR GLVYFVAAKE 550
    NPTERHIYTV KLDGSDLQPI VDTKSAGYYS ISLSAGAGYA LLKYEGPDIP 600
    WQKVISTPAN EEKYEESIEK NPGLADMARK YALPSLHYQT ITISGYELQV 650
    VERRPANFNP DKKYPVLFHL YGGPGSQTVT KKFKVDFQSY VASNLGYIVV 700
    TVDGRGTGFI GRKARCAVRG NLGHYEAIDQ IETAKAWGKR SYVDAGRMAI 750
    WGWSYGGFMT LKTLEQDAGQ TFQYGMAVAP VTDWRFYDSI YTERYMHTPQ 800
    NNPEGYDRSA ISNVTALDQA VRFMIVHGSG DDNVHIQNTL TLLDKLDLGS 850
    VKNFDVHVYP DSDHSIYFHN ANKMVYQRLS DWLVNAFNGE WVKTRDPIPH 900
    KSLARRALGL INILRNG 917
    Length:917
    Mass (Da):102,500
    Last modified:September 1, 2009 - v1
    Checksum:i3986DB9EBD68189D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFW01000014 Genomic DNA. Translation: EER28722.1.
    RefSeqiXP_003070867.1. XM_003070821.1.
    UniGeneiCpo.2.

    Genome annotation databases

    GeneIDi9696361.
    KEGGicpw:CPC735_039860.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFW01000014 Genomic DNA. Translation: EER28722.1 .
    RefSeqi XP_003070867.1. XM_003070821.1.
    UniGenei Cpo.2.

    3D structure databases

    ProteinModelPortali C5P334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 222929.C5P334.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9696361.
    KEGGi cpw:CPC735_039860.

    Phylogenomic databases

    eggNOGi COG1506.
    KOi K01282.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C735.

    Entry informationi

    Entry nameiDAPB_COCP7
    AccessioniPrimary (citable) accession number: C5P334
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3