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C5P334 (DAPB_COCP7) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:CPC735_039860
OrganismCoccidioides posadasii (strain C735) (Valley fever fungus) [Complete proteome]
Taxonomic identifier222929 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length917 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 917917Probable dipeptidyl-aminopeptidase B
PRO_0000412142

Regions

Topological domain1 – 9090Cytoplasmic Potential
Transmembrane91 – 11121Helical; Signal-anchor for type II membrane protein; Potential
Topological domain112 – 917806Vacuolar Potential

Sites

Active site7541Charge relay system By similarity
Active site8311Charge relay system By similarity
Active site8641Charge relay system By similarity

Amino acid modifications

Glycosylation3501N-linked (GlcNAc...) Potential
Glycosylation4651N-linked (GlcNAc...) Potential
Glycosylation8131N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5P334 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 3986DB9EBD68189D

FASTA917102,500
        10         20         30         40         50         60 
MGVEKRINDE EMQPLAERDD KSRDSIDSTS TASISLALLG GANGSAHGSR AARTRKSENQ 

        70         80         90        100        110        120 
EKYHDDEEEG DLEEGFVPPA GGWSAPRKVS VIFTLIVTLC IAGWLVAFFV LLGRHKDSSK 

       130        140        150        160        170        180 
DAAVSQGESN IIPGIYSGGR GGKKLDLDGV LFGNWSPKSH DISWFPGPNG ADGLLLEQGG 

       190        200        210        220        230        240 
DRNKAYLRVE DIRSRNPGNK ADDTIVLMRE SSFMVGKRLV RPSKVWPSPD LKTVLVMSDQ 

       250        260        270        280        290        300 
RKNWRHSYTG NYWIFDVETQ TGEPLDPESL DGGIQLASWS PNSDAIVFTR KNNMFIRRLP 

       310        320        330        340        350        360 
SKNVKQITTD GGTNLFYGIP DWVYEEEVFS DSSATWWDGD GKFVAFLRTN ESRVPEYPVQ 

       370        380        390        400        410        420 
YFIPNTNKPS RPSEENYPDI RKIKYPKAGA PNPVVNIQFF DVEKEEVFSV DVKDDLPDDD 

       430        440        450        460        470        480 
RLVIGVTWAS NGNVLVRETN RESDRLSVVL IDAAKRAGKV VRSRNFSSLD GGWVEPSQTT 

       490        500        510        520        530        540 
HFVPADPKNG RPHDGYIETI PHDGFEHLAY FTPMDNSEPT VLTSGDWEVV DAPSAVDLKR 

       550        560        570        580        590        600 
GLVYFVAAKE NPTERHIYTV KLDGSDLQPI VDTKSAGYYS ISLSAGAGYA LLKYEGPDIP 

       610        620        630        640        650        660 
WQKVISTPAN EEKYEESIEK NPGLADMARK YALPSLHYQT ITISGYELQV VERRPANFNP 

       670        680        690        700        710        720 
DKKYPVLFHL YGGPGSQTVT KKFKVDFQSY VASNLGYIVV TVDGRGTGFI GRKARCAVRG 

       730        740        750        760        770        780 
NLGHYEAIDQ IETAKAWGKR SYVDAGRMAI WGWSYGGFMT LKTLEQDAGQ TFQYGMAVAP 

       790        800        810        820        830        840 
VTDWRFYDSI YTERYMHTPQ NNPEGYDRSA ISNVTALDQA VRFMIVHGSG DDNVHIQNTL 

       850        860        870        880        890        900 
TLLDKLDLGS VKNFDVHVYP DSDHSIYFHN ANKMVYQRLS DWLVNAFNGE WVKTRDPIPH 

       910 
KSLARRALGL INILRNG 

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References

[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C735.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ACFW01000014 Genomic DNA. Translation: EER28722.1.
RefSeqXP_003070867.1. XM_003070821.1.
UniGeneCpo.2.

3D structure databases

ProteinModelPortalC5P334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING222929.C5P334.

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9696361.
KEGGcpw:CPC735_039860.

Phylogenomic databases

eggNOGCOG1506.
KOK01282.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPB_COCP7
AccessionPrimary (citable) accession number: C5P334
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries