Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

CPC735_039850

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (CPC735_039850), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (CPC735_030760), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (CPC735_024240)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:CPC735_039850Imported
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)Imported
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CPC735_039850.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi222929.XP_003070866.1.

Structurei

3D structure databases

ProteinModelPortaliC5P333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiCOG1053.
KOiK00234.
OrthoDBiEOG7V76G3.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5P333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNGLRSLA PATRFSRSLR DQRRLFSSSR PAARIITSQP LRAKEASPFL
60 70 80 90 100
TKKYPVIDHE YDAVVVGAGG AGLRAAFGLA EAGFNTACVT KLFPTRSHTV
110 120 130 140 150
AAQGGINAAL GNMHEDDWRW HMYDTVKGSD WLGDQDAIHY MTREAPQSVI
160 170 180 190 200
ELEGYGCPFS RTEDGKIYQR AFGGQSKEFG KGGQAYRCCA AADRTGHALL
210 220 230 240 250
HTLYGQSLRY NASYFIEYFA LDLLMENGEC KGILAYNQED GTLHRFKAHH
260 270 280 290 300
TVLATGGYGR AYFSCTSAHT CTGDGMAMVA RAGLPNQDLE FVQFHPTGIY
310 320 330 340 350
GAGCLITEGA RGEGGYLLNS NGERFMERYA STAKDLASRD VVSRSMTLEI
360 370 380 390 400
REGRGVGPEK DHIYLQLSHL PPEILHERLP GISETASIFA GVDVTKQPIP
410 420 430 440 450
VLPTVHYNMG GIPTRYTGEV LTIDEKGNDK VVPGLYACGE AACVSVHGAN
460 470 480 490 500
RLGANSLLDL IVFGRAVSHT IRDNATPNTP HKEISADAGA ESIEVLDKIR
510 520 530 540 550
TADGPKSTFD IRNAMQKTMQ TDVSVFRTQE SLDEGVRKIN EVDQMFAQVG
560 570 580 590 600
TKDRSMIWNS DLVETLELRN LLTCATQTAV AAANRKESRG AHAREDYPDR
610 620 630 640
DDANWMKHTL TFQKEPHGKV DLTYRAVTQT TLDESECKPV PPFKRVY
Length:647
Mass (Da):71,140
Last modified:September 1, 2009 - v1
Checksum:iB643ED174B3AB31B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000014 Genomic DNA. Translation: EER28721.1.
RefSeqiXP_003070866.1. XM_003070820.1.
UniGeneiCpo.2345.

Genome annotation databases

GeneIDi9696360.
KEGGicpw:CPC735_039850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000014 Genomic DNA. Translation: EER28721.1.
RefSeqiXP_003070866.1. XM_003070820.1.
UniGeneiCpo.2345.

3D structure databases

ProteinModelPortaliC5P333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222929.XP_003070866.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9696360.
KEGGicpw:CPC735_039850.

Organism-specific databases

EuPathDBiFungiDB:CPC735_039850.

Phylogenomic databases

eggNOGiCOG1053.
KOiK00234.
OrthoDBiEOG7V76G3.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735Imported.

Entry informationi

Entry nameiC5P333_COCP7
AccessioniPrimary (citable) accession number: C5P333
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: July 22, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.