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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

CPC735_039850

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (CPC735_039850), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (CPC735_030760), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (CPC735_024240)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:CPC735_039850Imported
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)Imported
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000009084 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CPC735_039850

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi222929.XP_003070866.1

Structurei

3D structure databases

ProteinModelPortaliC5P333
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 457FAD_binding_2InterPro annotationAdd BLAST396
Domaini512 – 647Succ_DH_flav_CInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
KOiK00234
OrthoDBiEOG092C17LB

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

C5P333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNGLRSLA PATRFSRSLR DQRRLFSSSR PAARIITSQP LRAKEASPFL
60 70 80 90 100
TKKYPVIDHE YDAVVVGAGG AGLRAAFGLA EAGFNTACVT KLFPTRSHTV
110 120 130 140 150
AAQGGINAAL GNMHEDDWRW HMYDTVKGSD WLGDQDAIHY MTREAPQSVI
160 170 180 190 200
ELEGYGCPFS RTEDGKIYQR AFGGQSKEFG KGGQAYRCCA AADRTGHALL
210 220 230 240 250
HTLYGQSLRY NASYFIEYFA LDLLMENGEC KGILAYNQED GTLHRFKAHH
260 270 280 290 300
TVLATGGYGR AYFSCTSAHT CTGDGMAMVA RAGLPNQDLE FVQFHPTGIY
310 320 330 340 350
GAGCLITEGA RGEGGYLLNS NGERFMERYA STAKDLASRD VVSRSMTLEI
360 370 380 390 400
REGRGVGPEK DHIYLQLSHL PPEILHERLP GISETASIFA GVDVTKQPIP
410 420 430 440 450
VLPTVHYNMG GIPTRYTGEV LTIDEKGNDK VVPGLYACGE AACVSVHGAN
460 470 480 490 500
RLGANSLLDL IVFGRAVSHT IRDNATPNTP HKEISADAGA ESIEVLDKIR
510 520 530 540 550
TADGPKSTFD IRNAMQKTMQ TDVSVFRTQE SLDEGVRKIN EVDQMFAQVG
560 570 580 590 600
TKDRSMIWNS DLVETLELRN LLTCATQTAV AAANRKESRG AHAREDYPDR
610 620 630 640
DDANWMKHTL TFQKEPHGKV DLTYRAVTQT TLDESECKPV PPFKRVY
Length:647
Mass (Da):71,140
Last modified:September 1, 2009 - v1
Checksum:iB643ED174B3AB31B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000014 Genomic DNA Translation: EER28721.1
RefSeqiXP_003070866.1, XM_003070820.1
UniGeneiCpo.2345

Genome annotation databases

EnsemblFungiiEER28721; EER28721; CPC735_039850
GeneIDi9696360
KEGGicpw:CPC735_039850

Similar proteinsi

Entry informationi

Entry nameiC5P333_COCP7
AccessioniPrimary (citable) accession number: C5P333
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: March 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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