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C5P212

- CBPYA_COCP7

UniProt

C5P212 - CBPYA_COCP7

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei263 – 2631PROSITE-ProRule annotation
    Active sitei455 – 4551PROSITE-ProRule annotation
    Active sitei517 – 5171PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:CPC735_036210
    OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
    Taxonomic identifieri222929 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000009084: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 122105By similarityPRO_0000407445Add
    BLAST
    Chaini123 – 539417Carboxypeptidase Y homolog APRO_0000407446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi176 ↔ 416By similarity
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi310 ↔ 324By similarity
    Disulfide bondi334 ↔ 357By similarity
    Disulfide bondi341 ↔ 350By similarity
    Disulfide bondi379 ↔ 386By similarity
    Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi222929.C5P212.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    KOiK13289.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C5P212-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKALTATLLV GTALAAVPPQ QPIQVPTEDS AWAKPLENLK DTFKTLGNDA    50
    KQAWNELASA FPDAINEYTL FSAPKKHTRR PDTHWDHIVR GSDVQSIWVE 100
    GADGQKRREV DGKLEKYDLR VKAVDPSKLG IDKVKQYSGY LDDKENDKHL 150
    FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFLELGPAS IDKNLKVVHN 200
    PYSWNSNASV IFLDQPVNVG FSYSGGSVSD TIAAGKDVYA LLTLFFKQFP 250
    QYATQDFHIA GESYAGHYIP VFASEILSHK NRNINLQSVL IGNGLTDPLT 300
    QYPHYRPMAC GEGGYPAVLD ESTCRSMDNS LPRCLSMIES CYSSESAWLC 350
    VPASIYCNNA MIGPYQRTGQ NPYDVRAKCE DGGSLCYSQL GYITEWLNQK 400
    SVMDALGVEV SSYDSCNMDI NRNFLFHGDW MKPFHRVVPG LIDQIRVLIY 450
    AGDADFICNW LGNQAWTDAL EWSGREKFAK AELKDLTIVD NENKGKNIGK 500
    VKSYGNFTFM RLFGGGHMVP LDQPEASLEF FNRWLGGEW 539
    Length:539
    Mass (Da):60,311
    Last modified:September 1, 2009 - v1
    Checksum:iA801B5BA731EAE37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ176864 Genomic DNA. Translation: ABA54912.1.
    ACFW01000012 Genomic DNA. Translation: EER28915.1.
    RefSeqiXP_003071060.1. XM_003071014.1.
    UniGeneiCpo.2989.

    Genome annotation databases

    GeneIDi9696555.
    KEGGicpw:CPC735_036210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ176864 Genomic DNA. Translation: ABA54912.1 .
    ACFW01000012 Genomic DNA. Translation: EER28915.1 .
    RefSeqi XP_003071060.1. XM_003071014.1.
    UniGenei Cpo.2989.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 222929.C5P212.

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9696555.
    KEGGi cpw:CPC735_036210.

    Phylogenomic databases

    eggNOGi COG2939.
    KOi K13289.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice."
      Tarcha E.J., Basrur V., Hung C.Y., Gardner M.J., Cole G.T.
      Infect. Immun. 74:516-527(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C735.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C735.

    Entry informationi

    Entry nameiCBPYA_COCP7
    AccessioniPrimary (citable) accession number: C5P212
    Secondary accession number(s): Q3HYC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3