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C5P212

- CBPYA_COCP7

UniProt

C5P212 - CBPYA_COCP7

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Protein
Carboxypeptidase Y homolog A
Gene
cpyA, CPC735_036210
Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei263 – 2631 By similarity
Active sitei455 – 4551 By similarity
Active sitei517 – 5171 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:CPC735_036210
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Propeptidei18 – 122105 By similarity
PRO_0000407445Add
BLAST
Chaini123 – 539417Carboxypeptidase Y homolog A
PRO_0000407446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi176 ↔ 416 By similarity
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi310 ↔ 324 By similarity
Disulfide bondi334 ↔ 357 By similarity
Disulfide bondi341 ↔ 350 By similarity
Disulfide bondi379 ↔ 386 By similarity
Glycosylationi506 – 5061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi222929.C5P212.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5P212-1 [UniParc]FASTAAdd to Basket

« Hide

MKALTATLLV GTALAAVPPQ QPIQVPTEDS AWAKPLENLK DTFKTLGNDA    50
KQAWNELASA FPDAINEYTL FSAPKKHTRR PDTHWDHIVR GSDVQSIWVE 100
GADGQKRREV DGKLEKYDLR VKAVDPSKLG IDKVKQYSGY LDDKENDKHL 150
FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFLELGPAS IDKNLKVVHN 200
PYSWNSNASV IFLDQPVNVG FSYSGGSVSD TIAAGKDVYA LLTLFFKQFP 250
QYATQDFHIA GESYAGHYIP VFASEILSHK NRNINLQSVL IGNGLTDPLT 300
QYPHYRPMAC GEGGYPAVLD ESTCRSMDNS LPRCLSMIES CYSSESAWLC 350
VPASIYCNNA MIGPYQRTGQ NPYDVRAKCE DGGSLCYSQL GYITEWLNQK 400
SVMDALGVEV SSYDSCNMDI NRNFLFHGDW MKPFHRVVPG LIDQIRVLIY 450
AGDADFICNW LGNQAWTDAL EWSGREKFAK AELKDLTIVD NENKGKNIGK 500
VKSYGNFTFM RLFGGGHMVP LDQPEASLEF FNRWLGGEW 539
Length:539
Mass (Da):60,311
Last modified:September 1, 2009 - v1
Checksum:iA801B5BA731EAE37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ176864 Genomic DNA. Translation: ABA54912.1.
ACFW01000012 Genomic DNA. Translation: EER28915.1.
RefSeqiXP_003071060.1. XM_003071014.1.
UniGeneiCpo.2989.

Genome annotation databases

GeneIDi9696555.
KEGGicpw:CPC735_036210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ176864 Genomic DNA. Translation: ABA54912.1 .
ACFW01000012 Genomic DNA. Translation: EER28915.1 .
RefSeqi XP_003071060.1. XM_003071014.1.
UniGenei Cpo.2989.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 222929.C5P212.

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9696555.
KEGGi cpw:CPC735_036210.

Phylogenomic databases

eggNOGi COG2939.
KOi K13289.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice."
    Tarcha E.J., Basrur V., Hung C.Y., Gardner M.J., Cole G.T.
    Infect. Immun. 74:516-527(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C735.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735.

Entry informationi

Entry nameiCBPYA_COCP7
AccessioniPrimary (citable) accession number: C5P212
Secondary accession number(s): Q3HYC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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