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C5P212 (CBPYA_COCP7) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:cpyA
ORF Names:CPC735_036210
OrganismCoccidioides posadasii (strain C735) (Valley fever fungus) [Complete proteome]
Taxonomic identifier222929 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 122105 By similarity
PRO_0000407445
Chain123 – 539417Carboxypeptidase Y homolog A
PRO_0000407446

Sites

Active site2631 By similarity
Active site4551 By similarity
Active site5171 By similarity

Amino acid modifications

Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation5061N-linked (GlcNAc...) Potential
Disulfide bond176 ↔ 416 By similarity
Disulfide bond310 ↔ 324 By similarity
Disulfide bond334 ↔ 357 By similarity
Disulfide bond341 ↔ 350 By similarity
Disulfide bond379 ↔ 386 By similarity

Sequences

Sequence LengthMass (Da)Tools
C5P212 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: A801B5BA731EAE37

FASTA53960,311
        10         20         30         40         50         60 
MKALTATLLV GTALAAVPPQ QPIQVPTEDS AWAKPLENLK DTFKTLGNDA KQAWNELASA 

        70         80         90        100        110        120 
FPDAINEYTL FSAPKKHTRR PDTHWDHIVR GSDVQSIWVE GADGQKRREV DGKLEKYDLR 

       130        140        150        160        170        180 
VKAVDPSKLG IDKVKQYSGY LDDKENDKHL FYWFFESRND PKNDPVVLWL NGGPGCSSLT 

       190        200        210        220        230        240 
GLFLELGPAS IDKNLKVVHN PYSWNSNASV IFLDQPVNVG FSYSGGSVSD TIAAGKDVYA 

       250        260        270        280        290        300 
LLTLFFKQFP QYATQDFHIA GESYAGHYIP VFASEILSHK NRNINLQSVL IGNGLTDPLT 

       310        320        330        340        350        360 
QYPHYRPMAC GEGGYPAVLD ESTCRSMDNS LPRCLSMIES CYSSESAWLC VPASIYCNNA 

       370        380        390        400        410        420 
MIGPYQRTGQ NPYDVRAKCE DGGSLCYSQL GYITEWLNQK SVMDALGVEV SSYDSCNMDI 

       430        440        450        460        470        480 
NRNFLFHGDW MKPFHRVVPG LIDQIRVLIY AGDADFICNW LGNQAWTDAL EWSGREKFAK 

       490        500        510        520        530 
AELKDLTIVD NENKGKNIGK VKSYGNFTFM RLFGGGHMVP LDQPEASLEF FNRWLGGEW 

« Hide

References

« Hide 'large scale' references
[1]"A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice."
Tarcha E.J., Basrur V., Hung C.Y., Gardner M.J., Cole G.T.
Infect. Immun. 74:516-527(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C735.
[2]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C735.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ176864 Genomic DNA. Translation: ABA54912.1.
ACFW01000012 Genomic DNA. Translation: EER28915.1.
RefSeqXP_003071060.1. XM_003071014.1.
UniGeneCpo.2989.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING222929.C5P212.

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9696555.
KEGGcpw:CPC735_036210.

Phylogenomic databases

eggNOGCOG2939.
KOK13289.
OrthoDBEOG7XDBR1.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_COCP7
AccessionPrimary (citable) accession number: C5P212
Secondary accession number(s): Q3HYC0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 1, 2009
Last modified: February 19, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries