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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei263PROSITE-ProRule annotation1
Active sitei455PROSITE-ProRule annotation1
Active sitei517PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERicocpo-q3hyc0. Carboxypeptidase_S10.
MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:CPC735_036210
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000009084 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CPC735_036210.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040744518 – 122By similarityAdd BLAST105
ChainiPRO_0000407446123 – 539Carboxypeptidase Y homolog AAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi176 ↔ 416By similarity
Glycosylationi207N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi310 ↔ 324By similarity
Disulfide bondi334 ↔ 357By similarity
Disulfide bondi341 ↔ 350By similarity
Disulfide bondi379 ↔ 386By similarity
Glycosylationi506N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi222929.XP_003071060.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
KOiK13289.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5P212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALTATLLV GTALAAVPPQ QPIQVPTEDS AWAKPLENLK DTFKTLGNDA
60 70 80 90 100
KQAWNELASA FPDAINEYTL FSAPKKHTRR PDTHWDHIVR GSDVQSIWVE
110 120 130 140 150
GADGQKRREV DGKLEKYDLR VKAVDPSKLG IDKVKQYSGY LDDKENDKHL
160 170 180 190 200
FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFLELGPAS IDKNLKVVHN
210 220 230 240 250
PYSWNSNASV IFLDQPVNVG FSYSGGSVSD TIAAGKDVYA LLTLFFKQFP
260 270 280 290 300
QYATQDFHIA GESYAGHYIP VFASEILSHK NRNINLQSVL IGNGLTDPLT
310 320 330 340 350
QYPHYRPMAC GEGGYPAVLD ESTCRSMDNS LPRCLSMIES CYSSESAWLC
360 370 380 390 400
VPASIYCNNA MIGPYQRTGQ NPYDVRAKCE DGGSLCYSQL GYITEWLNQK
410 420 430 440 450
SVMDALGVEV SSYDSCNMDI NRNFLFHGDW MKPFHRVVPG LIDQIRVLIY
460 470 480 490 500
AGDADFICNW LGNQAWTDAL EWSGREKFAK AELKDLTIVD NENKGKNIGK
510 520 530
VKSYGNFTFM RLFGGGHMVP LDQPEASLEF FNRWLGGEW
Length:539
Mass (Da):60,311
Last modified:September 1, 2009 - v1
Checksum:iA801B5BA731EAE37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176864 Genomic DNA. Translation: ABA54912.1.
ACFW01000012 Genomic DNA. Translation: EER28915.1.
RefSeqiXP_003071060.1. XM_003071014.1.
UniGeneiCpo.2989.

Genome annotation databases

EnsemblFungiiEER28915; EER28915; CPC735_036210.
GeneIDi9696555.
KEGGicpw:CPC735_036210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176864 Genomic DNA. Translation: ABA54912.1.
ACFW01000012 Genomic DNA. Translation: EER28915.1.
RefSeqiXP_003071060.1. XM_003071014.1.
UniGeneiCpo.2989.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222929.XP_003071060.1.

Protein family/group databases

ESTHERicocpo-q3hyc0. Carboxypeptidase_S10.
MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEER28915; EER28915; CPC735_036210.
GeneIDi9696555.
KEGGicpw:CPC735_036210.

Organism-specific databases

EuPathDBiFungiDB:CPC735_036210.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
KOiK13289.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_COCP7
AccessioniPrimary (citable) accession number: C5P212
Secondary accession number(s): Q3HYC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 1, 2009
Last modified: September 7, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.