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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei263 – 2631PROSITE-ProRule annotation
Active sitei455 – 4551PROSITE-ProRule annotation
Active sitei517 – 5171PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:CPC735_036210
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 122105By similarityPRO_0000407445Add
BLAST
Chaini123 – 539417Carboxypeptidase Y homolog APRO_0000407446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi176 ↔ 416By similarity
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi310 ↔ 324By similarity
Disulfide bondi334 ↔ 357By similarity
Disulfide bondi341 ↔ 350By similarity
Disulfide bondi379 ↔ 386By similarity
Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi222929.C5P212.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5P212-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKALTATLLV GTALAAVPPQ QPIQVPTEDS AWAKPLENLK DTFKTLGNDA
60 70 80 90 100
KQAWNELASA FPDAINEYTL FSAPKKHTRR PDTHWDHIVR GSDVQSIWVE
110 120 130 140 150
GADGQKRREV DGKLEKYDLR VKAVDPSKLG IDKVKQYSGY LDDKENDKHL
160 170 180 190 200
FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFLELGPAS IDKNLKVVHN
210 220 230 240 250
PYSWNSNASV IFLDQPVNVG FSYSGGSVSD TIAAGKDVYA LLTLFFKQFP
260 270 280 290 300
QYATQDFHIA GESYAGHYIP VFASEILSHK NRNINLQSVL IGNGLTDPLT
310 320 330 340 350
QYPHYRPMAC GEGGYPAVLD ESTCRSMDNS LPRCLSMIES CYSSESAWLC
360 370 380 390 400
VPASIYCNNA MIGPYQRTGQ NPYDVRAKCE DGGSLCYSQL GYITEWLNQK
410 420 430 440 450
SVMDALGVEV SSYDSCNMDI NRNFLFHGDW MKPFHRVVPG LIDQIRVLIY
460 470 480 490 500
AGDADFICNW LGNQAWTDAL EWSGREKFAK AELKDLTIVD NENKGKNIGK
510 520 530
VKSYGNFTFM RLFGGGHMVP LDQPEASLEF FNRWLGGEW
Length:539
Mass (Da):60,311
Last modified:September 1, 2009 - v1
Checksum:iA801B5BA731EAE37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176864 Genomic DNA. Translation: ABA54912.1.
ACFW01000012 Genomic DNA. Translation: EER28915.1.
RefSeqiXP_003071060.1. XM_003071014.1.
UniGeneiCpo.2989.

Genome annotation databases

GeneIDi9696555.
KEGGicpw:CPC735_036210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176864 Genomic DNA. Translation: ABA54912.1.
ACFW01000012 Genomic DNA. Translation: EER28915.1.
RefSeqiXP_003071060.1. XM_003071014.1.
UniGeneiCpo.2989.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222929.C5P212.

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9696555.
KEGGicpw:CPC735_036210.

Phylogenomic databases

eggNOGiCOG2939.
KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice."
    Tarcha E.J., Basrur V., Hung C.Y., Gardner M.J., Cole G.T.
    Infect. Immun. 74:516-527(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C735.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735.

Entry informationi

Entry nameiCBPYA_COCP7
AccessioniPrimary (citable) accession number: C5P212
Secondary accession number(s): Q3HYC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 1, 2009
Last modified: January 7, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.