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C5P047

- C5P047_COCP7

UniProt

C5P047 - C5P047_COCP7

Protein

Kynureninase

Gene

BNA5

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei138 – 1381Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei139 – 1391Pyridoxal phosphateUniRule annotation
    Binding sitei252 – 2521Pyridoxal phosphateUniRule annotation
    Binding sitei255 – 2551Pyridoxal phosphateUniRule annotation
    Binding sitei277 – 2771Pyridoxal phosphateUniRule annotation
    Binding sitei315 – 3151Pyridoxal phosphateUniRule annotation
    Binding sitei343 – 3431Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    Biosynthesis of nicotinic acid protein 5UniRule annotation
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:BNA5UniRule annotation
    ORF Names:CPC735_073740Imported
    OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)Imported
    Taxonomic identifieri222929 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000009084: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi222929.C5P047.

    Structurei

    3D structure databases

    ProteinModelPortaliC5P047.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni166 – 1694Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    KOiK01556.
    OrthoDBiEOG7V1G0J.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5P047-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADSSKAPLP FRDSALSFKR EYAESLDAQD PLREFRNQFI IPSKADLKRK    50
    SLAVAEGESP SSDCIYLCGN SLGLQPKNAR TYIDRFLQTW ATKAVLGHFT 100
    KLEDSPFPPY MDYDDVTSKL MAQVVGALPS EVAVMSTLTG NLHLLMASFY 150
    RPTKEKYKII LEGKAFPSDH YAVESQIRHH GFDPKDAMVL IEPKDLKEPV 200
    LPTERILKTI DEHASSTALI LLPGIQYYSG QYLDIPTITA HAHSKGLLIG 250
    WDCAHAAGNV ELKLHNWDVD FAAWCTYKYM NSGPGSMGAL FVHEKHGQVN 300
    LENKEDPYRH RLTGWWGGDK SLRFLMDNNF VPRPGAAGFQ LSNPSVLDMT 350
    AVLSSLDIFD KATMPALRKK SLELTAYLEH LLLNSPEGVR PSGDPFSIIT 400
    PSDPEARGAQ LSVLLKPGLL DSVFSHLVDN GVILDERKPD VIRVAPAPLY 450
    NTFTDVWDFV QIFFDACRKA AQEKDTTS 478
    Length:478
    Mass (Da):53,246
    Last modified:September 1, 2009 - v1
    Checksum:i58E6F000CBE8957C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFW01000009 Genomic DNA. Translation: EER29692.1.
    RefSeqiXP_003071837.1. XM_003071791.1.
    UniGeneiCpo.6523.

    Genome annotation databases

    GeneIDi9697331.
    KEGGicpw:CPC735_073740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFW01000009 Genomic DNA. Translation: EER29692.1 .
    RefSeqi XP_003071837.1. XM_003071791.1.
    UniGenei Cpo.6523.

    3D structure databases

    ProteinModelPortali C5P047.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 222929.C5P047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9697331.
    KEGGi cpw:CPC735_073740.

    Phylogenomic databases

    eggNOGi COG3844.
    KOi K01556.
    OrthoDBi EOG7V1G0J.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C735Imported.

    Entry informationi

    Entry nameiC5P047_COCP7
    AccessioniPrimary (citable) accession number: C5P047
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3