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C5P047

- C5P047_COCP7

UniProt

C5P047 - C5P047_COCP7

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Protein

Kynureninase

Gene

BNA5

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei139 – 1391Pyridoxal phosphateUniRule annotation
Binding sitei252 – 2521Pyridoxal phosphateUniRule annotation
Binding sitei255 – 2551Pyridoxal phosphateUniRule annotation
Binding sitei277 – 2771Pyridoxal phosphateUniRule annotation
Binding sitei315 – 3151Pyridoxal phosphateUniRule annotation
Binding sitei343 – 3431Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:BNA5UniRule annotation
ORF Names:CPC735_073740Imported
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)Imported
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000009084: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi222929.C5P047.

Structurei

3D structure databases

ProteinModelPortaliC5P047.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 1694Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
KOiK01556.
OrthoDBiEOG7V1G0J.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

C5P047-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADSSKAPLP FRDSALSFKR EYAESLDAQD PLREFRNQFI IPSKADLKRK
60 70 80 90 100
SLAVAEGESP SSDCIYLCGN SLGLQPKNAR TYIDRFLQTW ATKAVLGHFT
110 120 130 140 150
KLEDSPFPPY MDYDDVTSKL MAQVVGALPS EVAVMSTLTG NLHLLMASFY
160 170 180 190 200
RPTKEKYKII LEGKAFPSDH YAVESQIRHH GFDPKDAMVL IEPKDLKEPV
210 220 230 240 250
LPTERILKTI DEHASSTALI LLPGIQYYSG QYLDIPTITA HAHSKGLLIG
260 270 280 290 300
WDCAHAAGNV ELKLHNWDVD FAAWCTYKYM NSGPGSMGAL FVHEKHGQVN
310 320 330 340 350
LENKEDPYRH RLTGWWGGDK SLRFLMDNNF VPRPGAAGFQ LSNPSVLDMT
360 370 380 390 400
AVLSSLDIFD KATMPALRKK SLELTAYLEH LLLNSPEGVR PSGDPFSIIT
410 420 430 440 450
PSDPEARGAQ LSVLLKPGLL DSVFSHLVDN GVILDERKPD VIRVAPAPLY
460 470
NTFTDVWDFV QIFFDACRKA AQEKDTTS
Length:478
Mass (Da):53,246
Last modified:September 1, 2009 - v1
Checksum:i58E6F000CBE8957C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000009 Genomic DNA. Translation: EER29692.1.
RefSeqiXP_003071837.1. XM_003071791.1.
UniGeneiCpo.6523.

Genome annotation databases

GeneIDi9697331.
KEGGicpw:CPC735_073740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFW01000009 Genomic DNA. Translation: EER29692.1 .
RefSeqi XP_003071837.1. XM_003071791.1.
UniGenei Cpo.6523.

3D structure databases

ProteinModelPortali C5P047.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 222929.C5P047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9697331.
KEGGi cpw:CPC735_073740.

Phylogenomic databases

eggNOGi COG3844.
KOi K01556.
OrthoDBi EOG7V1G0J.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C735Imported.

Entry informationi

Entry nameiC5P047_COCP7
AccessioniPrimary (citable) accession number: C5P047
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3