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C5P047 (C5P047_COCP7) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Subcellular location

Cytoplasm By similarity PIRNR PIRNR038800.

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Sequences

Sequence LengthMass (Da)Tools
C5P047 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 58E6F000CBE8957C

FASTA47853,246
        10         20         30         40         50         60 
MADSSKAPLP FRDSALSFKR EYAESLDAQD PLREFRNQFI IPSKADLKRK SLAVAEGESP 

        70         80         90        100        110        120 
SSDCIYLCGN SLGLQPKNAR TYIDRFLQTW ATKAVLGHFT KLEDSPFPPY MDYDDVTSKL 

       130        140        150        160        170        180 
MAQVVGALPS EVAVMSTLTG NLHLLMASFY RPTKEKYKII LEGKAFPSDH YAVESQIRHH 

       190        200        210        220        230        240 
GFDPKDAMVL IEPKDLKEPV LPTERILKTI DEHASSTALI LLPGIQYYSG QYLDIPTITA 

       250        260        270        280        290        300 
HAHSKGLLIG WDCAHAAGNV ELKLHNWDVD FAAWCTYKYM NSGPGSMGAL FVHEKHGQVN 

       310        320        330        340        350        360 
LENKEDPYRH RLTGWWGGDK SLRFLMDNNF VPRPGAAGFQ LSNPSVLDMT AVLSSLDIFD 

       370        380        390        400        410        420 
KATMPALRKK SLELTAYLEH LLLNSPEGVR PSGDPFSIIT PSDPEARGAQ LSVLLKPGLL 

       430        440        450        460        470 
DSVFSHLVDN GVILDERKPD VIRVAPAPLY NTFTDVWDFV QIFFDACRKA AQEKDTTS

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References

[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C735.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ACFW01000009 Genomic DNA. Translation: EER29692.1.
RefSeqXP_003071837.1. XM_003071791.1.
UniGeneCpo.6523.

3D structure databases

ProteinModelPortalC5P047.
ModBaseSearch...

Protein-protein interaction databases

STRING222929.C5P047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9697331.
KEGGcpw:CPC735_073740.

Phylogenomic databases

eggNOGCOG3844.
KOK01556.

Enzyme and pathway databases

UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC5P047_COCP7
AccessionPrimary (citable) accession number: C5P047
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 3, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info