SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C5MK33

- UT1_SHEEP

UniProt

C5MK33 - UT1_SHEEP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Urea transporter 1
Gene
SLC14A1
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei334 – 3341Important for channel permeability By similarity

GO - Molecular functioni

  1. urea channel activity Source: UniProtKB
  2. water transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. urea transmembrane transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporter 1
Alternative name(s):
Solute carrier family 14 member 1
Urea transporter B
Short name:
UT-B
Urea transporter, erythrocyte
Gene namesi
Name:SLC14A1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity. Basolateral cell membrane; Multi-pass membrane protein By similarity
Note: Restricted to the basolateral membrane in various portions of the urothelium By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei47 – 6418Helical; By similarity
Add
BLAST
Intramembranei68 – 8316Helical; By similarity
Add
BLAST
Transmembranei86 – 10520Helical; By similarity
Add
BLAST
Transmembranei110 – 13223Helical; By similarity
Add
BLAST
Transmembranei139 – 16325Helical; By similarity
Add
BLAST
Transmembranei168 – 18821Helical; By similarity
Add
BLAST
Intramembranei215 – 22915Helical; By similarity
Add
BLAST
Intramembranei234 – 24512Helical; By similarity
Add
BLAST
Transmembranei250 – 26920Helical; By similarity
Add
BLAST
Transmembranei279 – 29921Helical; By similarity
Add
BLAST
Transmembranei304 – 32522Helical; By similarity
Add
BLAST
Transmembranei328 – 34821Helical; By similarity
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Urea transporter 1
PRO_0000410965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi206 – 2061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotrimer; each subunit contains a pore through which urea permeates. Identified in a complex with STOM By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 1 hit.
[Graphical view]
PIRSFiPIRSF016502. Urea_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

C5MK33-1 [UniParc]FASTAAdd to Basket

« Hide

MDDNPTAVKL DQGGNQAPQG QGRRRLPKAL GYITGDMKEF ANWLKDKPQA    50
LQFVDWVLRG ISQVVFVSNP ISGILILVGL LVQNPWCALN GCVGTVVSTL 100
TALLLNQDRS AITAGLQGYN ATLVGILMAI YSDKGNYFWW LLFPVSAMSM 150
TCPIFSSALN SVLSKWDLPV FTLPFNMALS MYLSATGHFN PFFPSTLVTP 200
VTSVPNVTWP DLSALQLLKS LPVGVGQIYG CDNPWAGGIF LGAILLSSPL 250
MCLHAAIGSL LGIIAGLSLS APFENIYAGL WGFNSSLACI AIGGMFMALT 300
WQTHLLALAC ALFTAYLGAS MSHVMAVVGL PSCTWPFCLA TLLFLLLTTK 350
NPNIYKMPIS KVTYPEENRI FYLQSTKRTV QGPL 384
Length:384
Mass (Da):41,499
Last modified:July 28, 2009 - v1
Checksum:iF1E6BA58C8113163
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ118969 mRNA. Translation: ACR78174.1.
RefSeqiNP_001156526.1. NM_001163054.1.
UniGeneiOar.19933.

Genome annotation databases

GeneIDi100302356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ118969 mRNA. Translation: ACR78174.1 .
RefSeqi NP_001156526.1. NM_001163054.1.
UniGenei Oar.19933.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100302356.

Organism-specific databases

CTDi 6563.

Family and domain databases

Gene3Di 1.10.3430.10. 1 hit.
InterProi IPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view ]
PANTHERi PTHR10464. PTHR10464. 1 hit.
Pfami PF03253. UT. 1 hit.
[Graphical view ]
PIRSFi PIRSF016502. Urea_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Urea transport in ovine forestomachs."
    Deiner C., Martens H., Lu Z., Kolisek M.
    Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ruminal epithelium.

Entry informationi

Entry nameiUT1_SHEEP
AccessioniPrimary (citable) accession number: C5MK33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi