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C5MK33 (UT1_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Urea transporter 1
Alternative name(s):
Solute carrier family 14 member 1
Urea transporter B
Short name=UT-B
Urea transporter, erythrocyte
Gene names
Name:SLC14A1
OrganismOvis aries (Sheep) [Complete proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Low-affinity facilitative urea transporter that allow rapid equilibration between the urinary space and the hyperosmotic interstitium. the rate of urea conduction is increased by hypoosmotic stress. Mediates urea transport in erythrocytes By similarity.

Subunit structure

Homotrimer By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Cell membrane By similarity.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Urea transporter 1
PRO_0000410965

Regions

Transmembrane61 – 8121Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane169 – 18921Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane305 – 32521Helical; Potential
Transmembrane327 – 34721Helical; Potential

Amino acid modifications

Glycosylation2061N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5MK33 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: F1E6BA58C8113163

FASTA38441,499
        10         20         30         40         50         60 
MDDNPTAVKL DQGGNQAPQG QGRRRLPKAL GYITGDMKEF ANWLKDKPQA LQFVDWVLRG 

        70         80         90        100        110        120 
ISQVVFVSNP ISGILILVGL LVQNPWCALN GCVGTVVSTL TALLLNQDRS AITAGLQGYN 

       130        140        150        160        170        180 
ATLVGILMAI YSDKGNYFWW LLFPVSAMSM TCPIFSSALN SVLSKWDLPV FTLPFNMALS 

       190        200        210        220        230        240 
MYLSATGHFN PFFPSTLVTP VTSVPNVTWP DLSALQLLKS LPVGVGQIYG CDNPWAGGIF 

       250        260        270        280        290        300 
LGAILLSSPL MCLHAAIGSL LGIIAGLSLS APFENIYAGL WGFNSSLACI AIGGMFMALT 

       310        320        330        340        350        360 
WQTHLLALAC ALFTAYLGAS MSHVMAVVGL PSCTWPFCLA TLLFLLLTTK NPNIYKMPIS 

       370        380 
KVTYPEENRI FYLQSTKRTV QGPL 

« Hide

References

[1]"Urea transport in ovine forestomachs."
Deiner C., Martens H., Lu Z., Kolisek M.
Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ruminal epithelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GQ118969 mRNA. Translation: ACR78174.1.
RefSeqNP_001156526.1. NM_001163054.1.
UniGeneOar.19933.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100302356.

Organism-specific databases

CTD6563.

Family and domain databases

InterProIPR004937. Urea_transporter.
[Graphical view]
PANTHERPTHR10464. PTHR10464. 1 hit.
PfamPF03253. UT. 1 hit.
[Graphical view]
PIRSFPIRSF016502. Urea_transporter. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUT1_SHEEP
AccessionPrimary (citable) accession number: C5MK33
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program