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C5MK33

- UT1_SHEEP

UniProt

C5MK33 - UT1_SHEEP

Protein

Urea transporter 1

Gene

SLC14A1

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei334 – 3341Important for channel permeabilityBy similarity

    GO - Molecular functioni

    1. urea channel activity Source: UniProtKB
    2. water transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. urea transmembrane transport Source: UniProtKB

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urea transporter 1
    Alternative name(s):
    Solute carrier family 14 member 1
    Urea transporter B
    Short name:
    UT-B
    Urea transporter, erythrocyte
    Gene namesi
    Name:SLC14A1
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Restricted to the basolateral membrane in various portions of the urothelium.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Urea transporter 1PRO_0000410965Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homotrimer; each subunit contains a pore through which urea permeates. Identified in a complex with STOM By similarity.By similarity

    Structurei

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei47 – 6418HelicalBy similarityAdd
    BLAST
    Intramembranei68 – 8316HelicalBy similarityAdd
    BLAST
    Intramembranei215 – 22915HelicalBy similarityAdd
    BLAST
    Intramembranei234 – 24512HelicalBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei86 – 10520HelicalBy similarityAdd
    BLAST
    Transmembranei110 – 13223HelicalBy similarityAdd
    BLAST
    Transmembranei139 – 16325HelicalBy similarityAdd
    BLAST
    Transmembranei168 – 18821HelicalBy similarityAdd
    BLAST
    Transmembranei250 – 26920HelicalBy similarityAdd
    BLAST
    Transmembranei279 – 29921HelicalBy similarityAdd
    BLAST
    Transmembranei304 – 32522HelicalBy similarityAdd
    BLAST
    Transmembranei328 – 34821HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the urea transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.3430.10. 1 hit.
    InterProiIPR029020. Ammonium/urea_transptr.
    IPR004937. Urea_transporter.
    [Graphical view]
    PANTHERiPTHR10464. PTHR10464. 1 hit.
    PfamiPF03253. UT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016502. Urea_transporter. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5MK33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDNPTAVKL DQGGNQAPQG QGRRRLPKAL GYITGDMKEF ANWLKDKPQA    50
    LQFVDWVLRG ISQVVFVSNP ISGILILVGL LVQNPWCALN GCVGTVVSTL 100
    TALLLNQDRS AITAGLQGYN ATLVGILMAI YSDKGNYFWW LLFPVSAMSM 150
    TCPIFSSALN SVLSKWDLPV FTLPFNMALS MYLSATGHFN PFFPSTLVTP 200
    VTSVPNVTWP DLSALQLLKS LPVGVGQIYG CDNPWAGGIF LGAILLSSPL 250
    MCLHAAIGSL LGIIAGLSLS APFENIYAGL WGFNSSLACI AIGGMFMALT 300
    WQTHLLALAC ALFTAYLGAS MSHVMAVVGL PSCTWPFCLA TLLFLLLTTK 350
    NPNIYKMPIS KVTYPEENRI FYLQSTKRTV QGPL 384
    Length:384
    Mass (Da):41,499
    Last modified:July 28, 2009 - v1
    Checksum:iF1E6BA58C8113163
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ118969 mRNA. Translation: ACR78174.1.
    RefSeqiNP_001156526.1. NM_001163054.1.
    UniGeneiOar.19933.

    Genome annotation databases

    GeneIDi100302356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ118969 mRNA. Translation: ACR78174.1 .
    RefSeqi NP_001156526.1. NM_001163054.1.
    UniGenei Oar.19933.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100302356.

    Organism-specific databases

    CTDi 6563.

    Family and domain databases

    Gene3Di 1.10.3430.10. 1 hit.
    InterProi IPR029020. Ammonium/urea_transptr.
    IPR004937. Urea_transporter.
    [Graphical view ]
    PANTHERi PTHR10464. PTHR10464. 1 hit.
    Pfami PF03253. UT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016502. Urea_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Urea transport in ovine forestomachs."
      Deiner C., Martens H., Lu Z., Kolisek M.
      Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ruminal epithelium.

    Entry informationi

    Entry nameiUT1_SHEEP
    AccessioniPrimary (citable) accession number: C5MK33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3