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C5MFP8

- KEX1_CANTT

UniProt

C5MFP8 - KEX1_CANTT

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831PROSITE-ProRule annotation
Active sitei393 – 3931PROSITE-ProRule annotation
Active sitei451 – 4511PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CTRG_04891
OrganismiCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Taxonomic identifieri294747 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000002037: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 564547LumenalSequence AnalysisAdd
BLAST
Transmembranei565 – 58521HelicalSequence AnalysisAdd
BLAST
Topological domaini586 – 707122CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 707690Pheromone-processing carboxypeptidase KEX1PRO_0000411911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5MFP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLSVFIILI NTLFVLAIPP KEGSDNNPSK KYLVTDLPGL YENVKPKISV
60 70 80 90 100
PLMFSGQLEL YPENNTHYFF WKFVDSELNQ DTSKKTIFWL NGGPGCSSMD
110 120 130 140 150
GALLETGPFR IDENEKVIYN NGSWHKFGDI IYVDQPAGTG FSFTNEYITD
160 170 180 190 200
LDQVAWYFLK FMEEYYKLFP NEINNEIYFA GESYAGQYIP YIADAILKRN
210 220 230 240 250
KNLKENDVKY DLKGILIGNG WVSPNQQSLS YLPFFINHGL IDKSHPRWGS
260 270 280 290 300
LLSKHEKCQK IVNKIDGHFD EADVHPYEVN SATCESILTD LLNYSQDRES
310 320 330 340 350
DSDHRCINMY DYTLRDSYPS CGMNWPFELK YVAPFLRKEE VMHDLNLVDL
360 370 380 390 400
KYWRECSGKV GRMFGARNSL PAVHLLPNIS QEIPIILFNG ANDIICNSDG
410 420 430 440 450
VLSYLDKLQW GGKVGFTNKD DQINWIYDNK EVGYILMERN ISFINIYNSS
460 470 480 490 500
HMVPYDLPDV SRALMDLVSG KYEEKEKDGK REFITYPLGE VRNKLGQEIP
510 520 530 540 550
ADESSKPIED KPDDKPIEDK PEETKPEQTK PEDETSSSTS EIIPTSEASF
560 570 580 590 600
IPEPEESTSS KFTRLIQLGV IFIIFWGVYI LYVSYRARPS SIIKKPARST
610 620 630 640 650
NSSGRKKNVQ WADQLNRFEE DENELGSPPP QGIIAKTISK ITGNTSNRGR
660 670 680 690 700
YAPAGDGSRE FTDDIELGEG ISDPNVDEFI IGSDDDEDDD EDVETHEGNP

KKTESKS
Length:707
Mass (Da):80,574
Last modified:July 28, 2009 - v1
Checksum:i1858B0F08F8E0492
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG692401 Genomic DNA. Translation: EER31161.1.
RefSeqiXP_002550593.1. XM_002550547.1.

Genome annotation databases

GeneIDi8298894.
KEGGictp:CTRG_04891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG692401 Genomic DNA. Translation: EER31161.1 .
RefSeqi XP_002550593.1. XM_002550547.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8298894.
KEGGi ctp:CTRG_04891.

Phylogenomic databases

KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-3404 / T1.

Entry informationi

Entry nameiKEX1_CANTT
AccessioniPrimary (citable) accession number: C5MFP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3