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C5MFP8

- KEX1_CANTT

UniProt

C5MFP8 - KEX1_CANTT

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei183 – 1831PROSITE-ProRule annotation
    Active sitei393 – 3931PROSITE-ProRule annotation
    Active sitei451 – 4511PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:CTRG_04891
    OrganismiCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
    Taxonomic identifieri294747 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000002037: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 707690Pheromone-processing carboxypeptidase KEX1PRO_0000411911Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 564547LumenalSequence AnalysisAdd
    BLAST
    Topological domaini586 – 707122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei565 – 58521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C5MFP8-1 [UniParc]FASTAAdd to Basket

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    MLLSVFIILI NTLFVLAIPP KEGSDNNPSK KYLVTDLPGL YENVKPKISV    50
    PLMFSGQLEL YPENNTHYFF WKFVDSELNQ DTSKKTIFWL NGGPGCSSMD 100
    GALLETGPFR IDENEKVIYN NGSWHKFGDI IYVDQPAGTG FSFTNEYITD 150
    LDQVAWYFLK FMEEYYKLFP NEINNEIYFA GESYAGQYIP YIADAILKRN 200
    KNLKENDVKY DLKGILIGNG WVSPNQQSLS YLPFFINHGL IDKSHPRWGS 250
    LLSKHEKCQK IVNKIDGHFD EADVHPYEVN SATCESILTD LLNYSQDRES 300
    DSDHRCINMY DYTLRDSYPS CGMNWPFELK YVAPFLRKEE VMHDLNLVDL 350
    KYWRECSGKV GRMFGARNSL PAVHLLPNIS QEIPIILFNG ANDIICNSDG 400
    VLSYLDKLQW GGKVGFTNKD DQINWIYDNK EVGYILMERN ISFINIYNSS 450
    HMVPYDLPDV SRALMDLVSG KYEEKEKDGK REFITYPLGE VRNKLGQEIP 500
    ADESSKPIED KPDDKPIEDK PEETKPEQTK PEDETSSSTS EIIPTSEASF 550
    IPEPEESTSS KFTRLIQLGV IFIIFWGVYI LYVSYRARPS SIIKKPARST 600
    NSSGRKKNVQ WADQLNRFEE DENELGSPPP QGIIAKTISK ITGNTSNRGR 650
    YAPAGDGSRE FTDDIELGEG ISDPNVDEFI IGSDDDEDDD EDVETHEGNP 700
    KKTESKS 707
    Length:707
    Mass (Da):80,574
    Last modified:July 28, 2009 - v1
    Checksum:i1858B0F08F8E0492
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG692401 Genomic DNA. Translation: EER31161.1.
    RefSeqiXP_002550593.1. XM_002550547.1.

    Genome annotation databases

    GeneIDi8298894.
    KEGGictp:CTRG_04891.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG692401 Genomic DNA. Translation: EER31161.1 .
    RefSeqi XP_002550593.1. XM_002550547.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8298894.
    KEGGi ctp:CTRG_04891.

    Phylogenomic databases

    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-3404 / T1.

    Entry informationi

    Entry nameiKEX1_CANTT
    AccessioniPrimary (citable) accession number: C5MFP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3