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C5MFP8 (KEX1_CANTT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:CTRG_04891
OrganismCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) [Complete proteome]
Taxonomic identifier294747 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 707690Pheromone-processing carboxypeptidase KEX1
PRO_0000411911

Regions

Topological domain18 – 564547Lumenal Potential
Transmembrane565 – 58521Helical; Potential
Topological domain586 – 707122Cytoplasmic Potential

Sites

Active site1831 By similarity
Active site3931 By similarity
Active site4511 By similarity

Amino acid modifications

Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation3781N-linked (GlcNAc...) Potential
Glycosylation4401N-linked (GlcNAc...) Potential
Glycosylation4481N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5MFP8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 1858B0F08F8E0492

FASTA70780,574
        10         20         30         40         50         60 
MLLSVFIILI NTLFVLAIPP KEGSDNNPSK KYLVTDLPGL YENVKPKISV PLMFSGQLEL 

        70         80         90        100        110        120 
YPENNTHYFF WKFVDSELNQ DTSKKTIFWL NGGPGCSSMD GALLETGPFR IDENEKVIYN 

       130        140        150        160        170        180 
NGSWHKFGDI IYVDQPAGTG FSFTNEYITD LDQVAWYFLK FMEEYYKLFP NEINNEIYFA 

       190        200        210        220        230        240 
GESYAGQYIP YIADAILKRN KNLKENDVKY DLKGILIGNG WVSPNQQSLS YLPFFINHGL 

       250        260        270        280        290        300 
IDKSHPRWGS LLSKHEKCQK IVNKIDGHFD EADVHPYEVN SATCESILTD LLNYSQDRES 

       310        320        330        340        350        360 
DSDHRCINMY DYTLRDSYPS CGMNWPFELK YVAPFLRKEE VMHDLNLVDL KYWRECSGKV 

       370        380        390        400        410        420 
GRMFGARNSL PAVHLLPNIS QEIPIILFNG ANDIICNSDG VLSYLDKLQW GGKVGFTNKD 

       430        440        450        460        470        480 
DQINWIYDNK EVGYILMERN ISFINIYNSS HMVPYDLPDV SRALMDLVSG KYEEKEKDGK 

       490        500        510        520        530        540 
REFITYPLGE VRNKLGQEIP ADESSKPIED KPDDKPIEDK PEETKPEQTK PEDETSSSTS 

       550        560        570        580        590        600 
EIIPTSEASF IPEPEESTSS KFTRLIQLGV IFIIFWGVYI LYVSYRARPS SIIKKPARST 

       610        620        630        640        650        660 
NSSGRKKNVQ WADQLNRFEE DENELGSPPP QGIIAKTISK ITGNTSNRGR YAPAGDGSRE 

       670        680        690        700 
FTDDIELGEG ISDPNVDEFI IGSDDDEDDD EDVETHEGNP KKTESKS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG692401 Genomic DNA. Translation: EER31161.1.
RefSeqXP_002550593.1. XM_002550547.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8298894.
KEGGctp:CTRG_04891.

Phylogenomic databases

KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_CANTT
AccessionPrimary (citable) accession number: C5MFP8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries