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Protein

Tryptophan synthase

Gene

CTRG_04034

Organism
Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Tryptophan synthase (CTRG_04034)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthaseUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
ORF Names:CTRG_04034Imported
OrganismiCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)Imported
Taxonomic identifieri294747 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000002037 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi294747.XP_002549737.1

Structurei

3D structure databases

ProteinModelPortaliC5MCT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini343 – 669PALPInterPro annotationAdd BLAST327

Phylogenomic databases

eggNOGiKOG1395 Eukaryota
KOG4175 Eukaryota
COG0133 LUCA
COG0159 LUCA
KOiK01694
OrthoDBiEOG092C0Y7R

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
cd04724 Tryptophan_synthase_alpha, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00131 Trp_synth_alpha, 1 hit
MF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR018204 Trp_synthase_alpha_AS
IPR002028 Trp_synthase_suA
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PF00290 Trp_syntA, 1 hit
TIGRFAMsiTIGR00262 trpA, 1 hit
TIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00167 TRP_SYNTHASE_ALPHA, 1 hit
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

C5MCT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALLKETFA RCKKEGRKAL VNFITAGFPT IEDTVPILKN MQEAGVDIIE
60 70 80 90 100
LGVPFSDPIA DGPTIQQANN VALENGITVP KVLQLLSQAR EQGVTVPIIL
110 120 130 140 150
MGYYNPILKY GEQKFLKDAA DAGASGFIVV DLPPEEAIKF RTECAQHGLS
160 170 180 190 200
YVPLVAPATS DERLKTLGQI ADSFIYVVSK MGTTGASTKV SSGIEELCAR
210 220 230 240 250
VRKFAGEDTP LAVGFGVSTR EHFETVGQVA DGVVIGSKIV TLIGESKPGA
260 270 280 290 300
RGQTAYDYVR SILGEDFKPS YPASFERSNA DASKETKAVL EETHKYNPKF
310 320 330 340 350
GDFGGQYVPE ALHTCLLELE KGFEDAVADP QFWKDFRDLY SYIGRPSSLH
360 370 380 390 400
KADRLTEHAG GAQIWLKRED LNHTGSHKIN NALAQVLIAK RLGKKKIIAE
410 420 430 440 450
TGAGQHGVAT ATACAKFGLE CTVFMGAEDT RRQALNVFRM KILGANVVAV
460 470 480 490 500
KNGTQTLRDA TSEAFRFWVS NLETTHYVVG SAIGPHPYPT LVRTFQSVIG
510 520 530 540 550
QETKEQFKEL NNGKLPNAVV ACVGGGSNST GMFSPFEHDT EVKMLGVEAG
560 570 580 590 600
GDGLDTDRHS ATLTAGIPGV FHGVKTYVLQ DDDGQVHDTH SVSAGLDYPG
610 620 630 640 650
VGPELAYWKS TGRADFIAAT DAQALEGFRL LSQLEGIIPA LESSHAIYGG
660 670 680 690 700
VQLAKSLPKD QHIVINVSGR GDKDVQSVAE VLPRLGEQIG WDLRFEEDPS

K
Length:701
Mass (Da):75,642
Last modified:July 28, 2009 - v1
Checksum:i235D82FD5FA8D65E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG692399 Genomic DNA Translation: EER32363.1
RefSeqiXP_002549737.1, XM_002549691.1

Genome annotation databases

EnsemblFungiiEER32363; EER32363; CTRG_04034
GeneIDi8297012
KEGGictp:CTRG_04034

Similar proteinsi

Entry informationi

Entry nameiC5MCT3_CANTT
AccessioniPrimary (citable) accession number: C5MCT3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 25, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health