ID   C5M6Y6_CANTT            Unreviewed;       329 AA.
AC   C5M6Y6;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=Protein URE2 {ECO:0000256|PIRNR:PIRNR037861};
GN   ORFNames=CTRG_01617 {ECO:0000313|EMBL:EER34756.1};
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747 {ECO:0000313|EMBL:EER34756.1, ECO:0000313|Proteomes:UP000002037};
RN   [1] {ECO:0000313|EMBL:EER34756.1, ECO:0000313|Proteomes:UP000002037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Plays an important role in the cellular response to the
CC       nitrogen source. {ECO:0000256|PIRNR:PIRNR037861}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037861}.
CC   -!- SIMILARITY: Belongs to the GST superfamily.
CC       {ECO:0000256|ARBA:ARBA00007409, ECO:0000256|PIRNR:PIRNR037861}.
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DR   EMBL; GG692396; EER34756.1; -; Genomic_DNA.
DR   RefSeq; XP_002547311.1; XM_002547265.1.
DR   AlphaFoldDB; C5M6Y6; -.
DR   STRING; 294747.C5M6Y6; -.
DR   EnsemblFungi; CTRG_01617-t43_1; CTRG_01617-t43_1-p1; CTRG_01617.
DR   GeneID; 8301267; -.
DR   KEGG; ctp:CTRG_01617; -.
DR   VEuPathDB; FungiDB:CTRG_01617; -.
DR   eggNOG; KOG0867; Eukaryota.
DR   HOGENOM; CLU_011226_14_1_1; -.
DR   OrthoDB; 1404190at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:EnsemblFungi.
DR   GO; GO:0051219; F:phosphoprotein binding; IEA:EnsemblFungi.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR   GO; GO:0010621; P:negative regulation of transcription by transcription factor localization; IEA:EnsemblFungi.
DR   GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR   GO; GO:0032447; P:protein urmylation; IEA:EnsemblFungi.
DR   GO; GO:0006808; P:regulation of nitrogen utilization; IEA:EnsemblFungi.
DR   CDD; cd03048; GST_N_Ure2p_like; 1.
DR   Gene3D; 1.20.1050.10; -; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017298; Ure2.
DR   PANTHER; PTHR44051; GLUTATHIONE S-TRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR44051:SF3; TRANSCRIPTIONAL REGULATOR URE2; 1.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PIRSF; PIRSF037861; Prion_URE2; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SFLD; SFLDG00358; Main_(cytGST); 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063,
KW   ECO:0000256|PIRNR:PIRNR037861};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002037}.
FT   DOMAIN          87..171
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          180..329
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  37405 MW;  EA9AC14D824C3F9A CRC64;
     MSDPRHPLNS GENNNNNNNN NNNSNTNNSN NTHTISNLSA GLKSVSLADQ QQNEVNLNLL
     QQQLHREATT QQQQSRITQF FQNQPAEGYT LFSHRSAPNG FKVAIILSEL NLPFNTIFLD
     FNNGEQRAPE FVTINPNARV PALIDHYNEN TSIWESGAII LYLVSKYLKE NGECSLWSDN
     LIEQSQISSW LFFQTSGHAP MIGQALHFRY FHSCPVPSAV ERYTDEVRRV YGVVEMALAE
     RREALIMDLD VENAAAYSAG TTPLSQSRYF DYPVWLVGDR ATVADLSFVP WNNVVDRIGI
     NLKVEFPEVY KWTKYMMRRP AVIRALRGD
//