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C5M276

- LIPA_CANTT

UniProt

C5M276 - LIPA_CANTT

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Protein
Lipoyl synthase, mitochondrial
Gene
CTRG_00165
Organism
Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi103 – 1031Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi109 – 1091Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi128 – 1281Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi132 – 1321Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi135 – 1351Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrial (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
ORF Names:CTRG_00165
OrganismiCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Taxonomic identifieri294747 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000002037: Unassembled WGS sequence

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 377Lipoyl synthase, mitochondrialUniRule annotationPRO_0000398261
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Structurei

3D structure databases

ProteinModelPortaliC5M276.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK03644.
OrthoDBiEOG79KPR7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5M276-1 [UniParc]FASTAAdd to Basket

« Hide

MISRTPLFRT SIPIQRTLAT NVKPRRKRTV FTDELNKGPS FEDFVSGKAK    50
DMMEDPLELA RKDPNAKLPK WLKVPIPKGK SFHNVKKDVR ELKLSTVCEE 100
AKCPNISECW GGKKSEATAT IMLLGDTCTR GCRFCSVKTN RKPAAPDPNE 150
PENTAEAIKR WGLGYVVLTT VDRDDLVDGG ARHLAETVEK IKQKAPQILV 200
EVLGGDFRGD LDMVEILANS GLDVYAHNLE TVEDLTPHIR DRRATYRQSL 250
AVLERAKKTK PSLVTKTSLM LGFGETDEQI MKTLKDLREI GCDVVTFGQY 300
MRPTKRHMKV VEYVTPEKFD YWRDTALDMG FLYVASGPLV RSSYKAGEAF 350
IENVLKKRRH NVGETPRLQS VAKPSVY 377
Length:377
Mass (Da):42,515
Last modified:July 28, 2009 - v1
Checksum:i144EC19BDF927A65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG692395 Genomic DNA. Translation: EER35426.1.
RefSeqiXP_002545384.1. XM_002545338.1.

Genome annotation databases

GeneIDi8301163.
KEGGictp:CTRG_00165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG692395 Genomic DNA. Translation: EER35426.1 .
RefSeqi XP_002545384.1. XM_002545338.1.

3D structure databases

ProteinModelPortali C5M276.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8301163.
KEGGi ctp:CTRG_00165.

Phylogenomic databases

KOi K03644.
OrthoDBi EOG79KPR7.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-3404 / T1.

Entry informationi

Entry nameiLIPA_CANTT
AccessioniPrimary (citable) accession number: C5M276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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