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C5K1Y9 (CBPYA_AJEDS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:CPYA
ORF Names:BDBG_08833
OrganismAjellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis) [Complete proteome]
Taxonomic identifier559298 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces

Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 123106 By similarity
PRO_0000407422
Chain124 – 545422Carboxypeptidase Y homolog A
PRO_0000407423

Sites

Active site2641 By similarity
Active site4551 By similarity
Active site5171 By similarity

Amino acid modifications

Glycosylation2081N-linked (GlcNAc...) Potential
Glycosylation4851N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Glycosylation5061N-linked (GlcNAc...) Potential
Disulfide bond177 ↔ 416 By similarity
Disulfide bond311 ↔ 325 By similarity
Disulfide bond335 ↔ 358 By similarity
Disulfide bond342 ↔ 351 By similarity
Disulfide bond380 ↔ 386 By similarity

Sequences

Sequence LengthMass (Da)Tools
C5K1Y9 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 242B1440A8EF227A

FASTA54560,297
        10         20         30         40         50         60 
MKSLALALLV GGAIAAGPQQ QVLQAPVDNP DVAEPPLQTI ADTFDHLRGQ ATNLWNDVID 

        70         80         90        100        110        120 
KVPNIMDTIT HTPPPKKFNR RPDSEWNHIV RGAEIQAVWV EGDDGEKHRK VGGKLEAYDL 

       130        140        150        160        170        180 
RVKAVDPKAL GVDTVRQYSG YLDDNENDKH LFYWFFESRN DPENDPVVLW LNGGPGCSSL 

       190        200        210        220        230        240 
TGLFLELGPS SITEDLKVNY NPYSWNANAS VIFLDQPVNV GYSYSGGSVS DTNAAGKDVY 

       250        260        270        280        290        300 
ALLTLFFEQF PEYAKQDFHI AGESYAGHYI PVFASEIMAH KERNINLKSI LIGNGLTDPL 

       310        320        330        340        350        360 
TQYPLYRPMA CGEGGYPAVL DQASCQSMDN ALPRCLSMIE ACYSSESAWT CVPASIYCNN 

       370        380        390        400        410        420 
AIIGPYQRTG RNPYDVRTDC EGGNLCYTQL GDISKYLNQA EVMKALGAEV STYDSCNMDI 

       430        440        450        460        470        480 
NRNFLFRGDW MKPFHRLVPG LIAEMPVLLY AGDADFICNW LGNKAWAEAL EYPGHAKFAA 

       490        500        510        520        530        540 
AEMKNLTIVD NKSKGKVIGQ VKSAGNFTFM RLYGGGHMVP LDQPEASLEF MNRWLKGEWS 


AKSSS 

« Hide

References

[1]"The genome sequence of Blastomyces dermatitidis strain SLH14081."
Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S. expand/collapse author list , Galagan J.E., Nusbaum C., Birren B.W.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SLH14081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG657476 Genomic DNA. Translation: EEQ74619.1.
RefSeqXP_002620806.1. XM_002620760.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8501362.

Phylogenomic databases

OrthoDBEOG7XDBR1.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_AJEDS
AccessionPrimary (citable) accession number: C5K1Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries