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C5K1Y9

- CBPYA_AJEDS

UniProt

C5K1Y9 - CBPYA_AJEDS

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Protein
Carboxypeptidase Y homolog A
Gene
CPYA, BDBG_08833
Organism
Ajellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei264 – 2641 By similarity
Active sitei455 – 4551 By similarity
Active sitei517 – 5171 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:BDBG_08833
OrganismiAjellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
Taxonomic identifieri559298 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000002038: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Propeptidei18 – 123106 By similarity
PRO_0000407422Add
BLAST
Chaini124 – 545422Carboxypeptidase Y homolog A
PRO_0000407423Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi177 ↔ 416 By similarity
Glycosylationi208 – 2081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi311 ↔ 325 By similarity
Disulfide bondi335 ↔ 358 By similarity
Disulfide bondi342 ↔ 351 By similarity
Disulfide bondi380 ↔ 386 By similarity
Glycosylationi485 – 4851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi506 – 5061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5K1Y9-1 [UniParc]FASTAAdd to Basket

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MKSLALALLV GGAIAAGPQQ QVLQAPVDNP DVAEPPLQTI ADTFDHLRGQ    50
ATNLWNDVID KVPNIMDTIT HTPPPKKFNR RPDSEWNHIV RGAEIQAVWV 100
EGDDGEKHRK VGGKLEAYDL RVKAVDPKAL GVDTVRQYSG YLDDNENDKH 150
LFYWFFESRN DPENDPVVLW LNGGPGCSSL TGLFLELGPS SITEDLKVNY 200
NPYSWNANAS VIFLDQPVNV GYSYSGGSVS DTNAAGKDVY ALLTLFFEQF 250
PEYAKQDFHI AGESYAGHYI PVFASEIMAH KERNINLKSI LIGNGLTDPL 300
TQYPLYRPMA CGEGGYPAVL DQASCQSMDN ALPRCLSMIE ACYSSESAWT 350
CVPASIYCNN AIIGPYQRTG RNPYDVRTDC EGGNLCYTQL GDISKYLNQA 400
EVMKALGAEV STYDSCNMDI NRNFLFRGDW MKPFHRLVPG LIAEMPVLLY 450
AGDADFICNW LGNKAWAEAL EYPGHAKFAA AEMKNLTIVD NKSKGKVIGQ 500
VKSAGNFTFM RLYGGGHMVP LDQPEASLEF MNRWLKGEWS AKSSS 545
Length:545
Mass (Da):60,297
Last modified:July 28, 2009 - v1
Checksum:i242B1440A8EF227A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG657476 Genomic DNA. Translation: EEQ74619.1.
RefSeqiXP_002620806.1. XM_002620760.1.

Genome annotation databases

GeneIDi8501362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG657476 Genomic DNA. Translation: EEQ74619.1 .
RefSeqi XP_002620806.1. XM_002620760.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8501362.

Phylogenomic databases

OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Blastomyces dermatitidis strain SLH14081."
    Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S.
    , Galagan J.E., Nusbaum C., Birren B.W.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SLH14081.

Entry informationi

Entry nameiCBPYA_AJEDS
AccessioniPrimary (citable) accession number: C5K1Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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