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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Ajellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei264PROSITE-ProRule annotation1
Active sitei455PROSITE-ProRule annotation1
Active sitei517PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:BDBG_08833
OrganismiAjellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
Taxonomic identifieri559298 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeBlastomyces
Proteomesi
  • UP000002038 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040742218 – 123By similarityAdd BLAST106
ChainiPRO_0000407423124 – 545Carboxypeptidase Y homolog AAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi177 ↔ 416By similarity
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi311 ↔ 325By similarity
Disulfide bondi335 ↔ 358By similarity
Disulfide bondi342 ↔ 351By similarity
Disulfide bondi380 ↔ 386By similarity
Glycosylationi485N-linked (GlcNAc...)Sequence analysis1
Glycosylationi491N-linked (GlcNAc...)Sequence analysis1
Glycosylationi506N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi559298.XP_002620806.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5K1Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLALALLV GGAIAAGPQQ QVLQAPVDNP DVAEPPLQTI ADTFDHLRGQ
60 70 80 90 100
ATNLWNDVID KVPNIMDTIT HTPPPKKFNR RPDSEWNHIV RGAEIQAVWV
110 120 130 140 150
EGDDGEKHRK VGGKLEAYDL RVKAVDPKAL GVDTVRQYSG YLDDNENDKH
160 170 180 190 200
LFYWFFESRN DPENDPVVLW LNGGPGCSSL TGLFLELGPS SITEDLKVNY
210 220 230 240 250
NPYSWNANAS VIFLDQPVNV GYSYSGGSVS DTNAAGKDVY ALLTLFFEQF
260 270 280 290 300
PEYAKQDFHI AGESYAGHYI PVFASEIMAH KERNINLKSI LIGNGLTDPL
310 320 330 340 350
TQYPLYRPMA CGEGGYPAVL DQASCQSMDN ALPRCLSMIE ACYSSESAWT
360 370 380 390 400
CVPASIYCNN AIIGPYQRTG RNPYDVRTDC EGGNLCYTQL GDISKYLNQA
410 420 430 440 450
EVMKALGAEV STYDSCNMDI NRNFLFRGDW MKPFHRLVPG LIAEMPVLLY
460 470 480 490 500
AGDADFICNW LGNKAWAEAL EYPGHAKFAA AEMKNLTIVD NKSKGKVIGQ
510 520 530 540
VKSAGNFTFM RLYGGGHMVP LDQPEASLEF MNRWLKGEWS AKSSS
Length:545
Mass (Da):60,297
Last modified:July 28, 2009 - v1
Checksum:i242B1440A8EF227A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG657476 Genomic DNA. Translation: EEQ74619.1.
RefSeqiXP_002620806.1. XM_002620760.1.

Genome annotation databases

EnsemblFungiiEEQ74619; EEQ74619; BDBG_08833.
GeneIDi8501362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG657476 Genomic DNA. Translation: EEQ74619.1.
RefSeqiXP_002620806.1. XM_002620760.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi559298.XP_002620806.1.

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEQ74619; EEQ74619; BDBG_08833.
GeneIDi8501362.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_AJEDS
AccessioniPrimary (citable) accession number: C5K1Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.