C5JQ04 (AMPP3_AJEDS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PEPP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	PEPP
ORF Names:	BDBG_04813

Organism

Ajellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis) [Complete proteome]

Taxonomic identifier

559298 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces › Ajellomyces dermatitidis

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Probable Xaa-Pro aminopeptidase PEPP		PRO_0000411861
Sites
	Metal binding	264	1	Manganese 2 By similarity
	Metal binding	275	1	Manganese 1 By similarity
	Metal binding	275	1	Manganese 2 By similarity
	Metal binding	398	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5JQ04 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 9989C2B4CA176C38	FASTA	468	52,142
	10 20 30 40 50 60 MDASVDKILA GKYPAKHHAK RVAARIRELG HGEAGVIYLE SQKTRMIEDN DGEMPFRQRR 70 80 90 100 110 120 NFFYLSGCPL PDSYLTYNIE EDHLTLFIPP IDEDSVIWSG LPLSPDEALE LYDVDAVLST 130 140 150 160 170 180 ADVNASLAHY CSAKEGTKVF AISDQVSPHI TFLPFQETDF DVLKRAAEEA RVVKDDYEIA 190 200 210 220 230 240 LLRRANEISS KAHVAVIKAA KSAMNERELE ATFIATCMSY GCREQSYHPI FAGGTNGATL 250 260 270 280 290 300 HYQKNDQDLV DKTTGEKKLN MLVDAGGEYR NYCADITRVF PLSGKFSAES RQIYDIVLEM 310 320 330 340 350 360 QMTSLAMIKA GVMWEDVHSN SHRVAIRGLL KLGILRGTEQ ELFDKGISVA FFPHGLGHYL 370 380 390 400 410 420 GMDTHDTGGN PNYEDKDSKF KYLRLRGVLA CGGVVTVEPG LYFCRFIIDP YLASPELGKY 430 440 450 460 IDANVLEKYW SVGGVRLEDN VVVTQNGYDN LTTAPKIPEE IEKLAAGP

References

[1]

"The genome sequence of Blastomyces dermatitidis strain SLH14081." Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S. , Galagan J.E., Nusbaum C., Birren B.W. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SLH14081.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG657455 Genomic DNA. Translation: EEQ78160.1.
RefSeq	XP_002624949.1. XM_002624903.1.
3D structure databases
ProteinModelPortal	C5JQ04.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8504593.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_AJEDS

Accession

Primary (citable) accession number: C5JQ04

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 28, 2009
Last modified:	March 6, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program