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C5JN54

- KEX1_AJEDS

UniProt

C5JN54 - KEX1_AJEDS

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ajellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851By similarity
Active sitei387 – 3871By similarity
Active sitei449 – 4491By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:BDBG_03944
OrganismiAjellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
Taxonomic identifieri559298 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000002038: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 638605Pheromone-processing carboxypeptidase KEX1PRO_0000411898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 520487LumenalSequence AnalysisAdd
BLAST
Topological domaini542 – 63897CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi564 – 5696Poly-Ser

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5JN54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFSETRAYS AWGAWSTWLT ICLALANLLP VTAKSAADYF VDSLPGQPEG
60 70 80 90 100
PLVKMHAGHI EINPETSGNF FFWHFANSHI ADKPRTIVWL NGGPGCSSED
110 120 130 140 150
GALMEIGPYR VTDDHMLNRT DGSWDEFANL LFVDQPVGTG FSYVSTGAYV
160 170 180 190 200
SELDEMTSQF VTFMEKWFEL FPHYEKDDLY FAGESYAGQY IPYIARAILD
210 220 230 240 250
RNKKESVQAQ NRQWNLKGLL IGNGWISPRH QYLSYLPYAY REGIIQGGTD
260 270 280 290 300
ASLRVEATIS KCMKKLNVED TTGTIHIADC EDILQTIVDE THKGNRCINM
310 320 330 340 350
YDIRLTDAYS ACGMNWPPDL KNIEPYLRYK NVTEALHINS DKQTGWTECS
360 370 380 390 400
GAVGGNFRAL KSKPSVELLP RLLEEGLPIL LFSGQKDLIC NHMGTEDMIK
410 420 430 440 450
DMKWSGGTGF ELSPGVWAPR QDWTFEGDSA GFYQQARNLT YVLFYNASHM
460 470 480 490 500
VPFDYPRRTR DMLDKFIGVD ITDIGGNPAD SRIGGEKGPT TSVGGHPNST
510 520 530 540 550
TAAEREKEKM KSAAWKAYYK SGEVALIVVA IAAIIWGVFI WRSRRQKLRN
560 570 580 590 600
SSHEYRGIYP MLGSSSSGSL PRFSNKRGRS ADDVEAADFD ETELDERLSR
610 620 630
AVSSRSSREH EPYAIGEEDG SDREGEGSDE RRGLVDKS
Length:638
Mass (Da):71,434
Last modified:July 28, 2009 - v1
Checksum:iD15DE8A8310A0954
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG657453 Genomic DNA. Translation: EEQ77618.1.
RefSeqiXP_002625885.1. XM_002625839.1.

Genome annotation databases

GeneIDi8505374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG657453 Genomic DNA. Translation: EEQ77618.1 .
RefSeqi XP_002625885.1. XM_002625839.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8505374.

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Blastomyces dermatitidis strain SLH14081."
    Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S.
    , Galagan J.E., Nusbaum C., Birren B.W.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SLH14081.

Entry informationi

Entry nameiKEX1_AJEDS
AccessioniPrimary (citable) accession number: C5JN54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3