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C5JN54

- KEX1_AJEDS

UniProt

C5JN54 - KEX1_AJEDS

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ajellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei185 – 1851By similarity
    Active sitei387 – 3871By similarity
    Active sitei449 – 4491By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:BDBG_03944
    OrganismiAjellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
    Taxonomic identifieri559298 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000002038: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 638605Pheromone-processing carboxypeptidase KEX1PRO_0000411898Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 520487LumenalSequence AnalysisAdd
    BLAST
    Topological domaini542 – 63897CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi564 – 5696Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C5JN54-1 [UniParc]FASTAAdd to Basket

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    MGFSETRAYS AWGAWSTWLT ICLALANLLP VTAKSAADYF VDSLPGQPEG    50
    PLVKMHAGHI EINPETSGNF FFWHFANSHI ADKPRTIVWL NGGPGCSSED 100
    GALMEIGPYR VTDDHMLNRT DGSWDEFANL LFVDQPVGTG FSYVSTGAYV 150
    SELDEMTSQF VTFMEKWFEL FPHYEKDDLY FAGESYAGQY IPYIARAILD 200
    RNKKESVQAQ NRQWNLKGLL IGNGWISPRH QYLSYLPYAY REGIIQGGTD 250
    ASLRVEATIS KCMKKLNVED TTGTIHIADC EDILQTIVDE THKGNRCINM 300
    YDIRLTDAYS ACGMNWPPDL KNIEPYLRYK NVTEALHINS DKQTGWTECS 350
    GAVGGNFRAL KSKPSVELLP RLLEEGLPIL LFSGQKDLIC NHMGTEDMIK 400
    DMKWSGGTGF ELSPGVWAPR QDWTFEGDSA GFYQQARNLT YVLFYNASHM 450
    VPFDYPRRTR DMLDKFIGVD ITDIGGNPAD SRIGGEKGPT TSVGGHPNST 500
    TAAEREKEKM KSAAWKAYYK SGEVALIVVA IAAIIWGVFI WRSRRQKLRN 550
    SSHEYRGIYP MLGSSSSGSL PRFSNKRGRS ADDVEAADFD ETELDERLSR 600
    AVSSRSSREH EPYAIGEEDG SDREGEGSDE RRGLVDKS 638
    Length:638
    Mass (Da):71,434
    Last modified:July 28, 2009 - v1
    Checksum:iD15DE8A8310A0954
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG657453 Genomic DNA. Translation: EEQ77618.1.
    RefSeqiXP_002625885.1. XM_002625839.1.

    Genome annotation databases

    GeneIDi8505374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG657453 Genomic DNA. Translation: EEQ77618.1 .
    RefSeqi XP_002625885.1. XM_002625839.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8505374.

    Phylogenomic databases

    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Blastomyces dermatitidis strain SLH14081."
      Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S.
      , Galagan J.E., Nusbaum C., Birren B.W.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SLH14081.

    Entry informationi

    Entry nameiKEX1_AJEDS
    AccessioniPrimary (citable) accession number: C5JN54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3