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C5JC30

- DAPB_AJEDS

UniProt

C5JC30 - DAPB_AJEDS

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
DAPB, BDBG_00095
Organism
Ajellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei754 – 7541Charge relay system By similarity
Active sitei831 – 8311Charge relay system By similarity
Active sitei864 – 8641Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:BDBG_00095
OrganismiAjellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)
Taxonomic identifieri559298 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000002038: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei96 – 11621Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini117 – 915799Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 915915Probable dipeptidyl-aminopeptidase B
PRO_0000412128Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi572 – 5721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi813 – 8131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi900 – 9001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC5JC30.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

C5JC30-1 [UniParc]FASTAAdd to Basket

« Hide

MAGEKGGSRD EEREPLTRGS IEFRDSINSF DYSSSTASLS LAVIDRINGS    50
TQDSRLGEKD QRDDDHDQYR NEEEYDVEDA DYIPSGGKTV QKTTKIVLWA 100
LLFLCVGGWS LAFVIFLFRG HDTPQTSIAS EENISSGGAR GNRITLDEVL 150
GGEWAPRAHS ISWFPGPNGE DGLILEKDNL SATAYLRVED IVGRKDPKAS 200
KKSIVLMQKK MFTVGRETVY SAQAWPSPDL KTVLVLSDQQ KNWRHSFTGK 250
YWLFDVETQT GQPLDPGAPD RRIQLASWSP QSDAVVFTRD NNMFLRKLTS 300
NEVATITTDG GVDLFYGVPD WVYEEEVFSG NSATWWASDG DYIAFLRTNE 350
SSVPDYPIQY FASRPSGENP KPGEENYPEV REVKYPKAGA PNPIVDLQFY 400
DVGKGEVFSV DVTSEFADDD RLIIEVLWAS NGKALVRETN RESDILSIAI 450
IDVLSRTGRI VRREDVNALD GGWVEPTQST RFIPADPDHG RLDDGYIDTV 500
IYEGRDQLAY FTPLDNPKPI MLTKGHSEVV NAPSGVDLKR GLVYFVVAGN 550
EPWERHIYSV NFDGTSLQPL TNVTESSYYD VSFSNGAGYA LLNYRGPKVP 600
WQKVINTPAN ENSFEAIIEQ NDHLSRKLRL FSLESKVYQH VTVDGFSLPV 650
MERRPPNFDP AKKYPVLFHL YGGPGSQTVS KKFSVDFQSY VASTLGYIVV 700
TVDGRGTGHI GRKARCIIRG NLGHYEARDQ IETAKKWAAK PYVDESRMAI 750
WGWSYGGFMT LKTLEQDGGR TFQYGMAVAP VTDWRYYDSI YTERYMRTPQ 800
HNQGGYDTSA ISNTTALASN IRFLLMHGTA DDNVHIQNSL TLLDKLDLDD 850
VDNYDVHVFP DSDHSIYFHN AHKMVYNRLG DWLINAFNGE WLKVHKPTPN 900
NSLFRRAETW GGLPV 915
Length:915
Mass (Da):102,912
Last modified:July 28, 2009 - v1
Checksum:i396FF2E496FA8454
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG657448 Genomic DNA. Translation: EEQ69277.1.
RefSeqiXP_002628849.1. XM_002628803.1.

Genome annotation databases

GeneIDi8508112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG657448 Genomic DNA. Translation: EEQ69277.1 .
RefSeqi XP_002628849.1. XM_002628803.1.

3D structure databases

ProteinModelPortali C5JC30.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8508112.

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Blastomyces dermatitidis strain SLH14081."
    Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S.
    , Galagan J.E., Nusbaum C., Birren B.W.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SLH14081.

Entry informationi

Entry nameiDAPB_AJEDS
AccessioniPrimary (citable) accession number: C5JC30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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