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C5J896 (KAX6G_OPICY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 6.16
Alternative name(s):
OcyC12
OrganismOpisthacanthus cayaporum (South American scorpion)
Taxonomic identifier573324 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaHemiscorpiidaeOpisthacanthus

Protein attributes

Sequence length67 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits voltage-gated potassium channels By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 6 subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 6743Potassium channel toxin alpha-KTx 6.16
PRO_0000398609

Amino acid modifications

Disulfide bond34 ↔ 55 By similarity
Disulfide bond40 ↔ 60 By similarity
Disulfide bond44 ↔ 62 By similarity
Disulfide bond50 ↔ 65 By similarity

Sequences

Sequence LengthMass (Da)Tools
C5J896 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 23ABD0E1A00BEA75

FASTA677,560
        10         20         30         40         50         60 
MNLKLALVLL LTVINVGMLP GATSNGNIKT DIKCYRNSHC NFHCEKSYYC QGSKCVRKRC 


NCYNCPL 

« Hide

References

[1]"Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum."
Silva E.C., Camargos T.S., Maranhao A.Q., Silva-Pereira I., Silva L.P., Possani L.D., Schwartz E.F.
Toxicon 54:252-261(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM998754 mRNA. Translation: CAX51400.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
[Graphical view]
SUPFAMSSF57095. SSF57095. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKAX6G_OPICY
AccessionPrimary (citable) accession number: C5J896
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 28, 2009
Last modified: October 16, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries