C5J896 (KAX6G_OPICY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin alpha-KTx 6.16 Alternative name(s): OcyC12
Organism	Opisthacanthus cayaporum (South American scorpion)
Taxonomic identifier	573324 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Hemiscorpiidae › Liochelinae › Opisthacanthus

Protein attributes

Sequence length	67 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits voltage-gated potassium channels By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 6 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 67	43	Potassium channel toxin alpha-KTx 6.16		PRO_0000398609
Amino acid modifications
	Disulfide bond	34 ↔ 55		By similarity
	Disulfide bond	40 ↔ 60		By similarity
	Disulfide bond	44 ↔ 62		By similarity
	Disulfide bond	50 ↔ 65		By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5J896 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 23ABD0E1A00BEA75	FASTA	67	7,560
	10 20 30 40 50 60 MNLKLALVLL LTVINVGMLP GATSNGNIKT DIKCYRNSHC NFHCEKSYYC QGSKCVRKRC NCYNCPL

References

[1]

"Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum." Silva E.C., Camargos T.S., Maranhao A.Q., Silva-Pereira I., Silva L.P., Possani L.D., Schwartz E.F. Toxicon 54:252-261(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM998754 mRNA. Translation: CAX51400.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KAX6G_OPICY

Accession

Primary (citable) accession number: C5J896

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 5, 2010
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program