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C5J7C4

- C5J7C4_MYCCR

UniProt

C5J7C4 - C5J7C4_MYCCR

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Protein
Thymidine kinase
Gene
tdk, MCJ_007010
Organism
Mycoplasma conjunctivae (strain ATCC 25834 / HRC/581 / NCTC 10147)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptor By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi149 – 1491Zinc By similarityUniRule annotation
Metal bindingi178 – 1781Zinc By similarityUniRule annotation
Metal bindingi181 – 1811Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarityUniRule annotation
Nucleotide bindingi89 – 924ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:MCJ_007010Imported
OrganismiMycoplasma conjunctivae (strain ATCC 25834 / HRC/581 / NCTC 10147)
Taxonomic identifieri572263 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001491: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi45361.MCJ_007010.

Structurei

3D structure databases

ProteinModelPortaliC5J7C4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiDHISEST.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5J7C4-1 [UniParc]FASTAAdd to Basket

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MYKKFFEGII EVITGPMFSG KSDELIKRVR TLSYANINTL VVKPKIDDRW    50
TTHEIVSRSG ARIPTFNVQD TQEIKALFEQ GDYQAIAVDE IQFFENEIIK 100
YLDDLANKGI RVIASGLDQD YARNPFGPLP QLMALAESVT KLQAICNICK 150
RAATTSARII NSKEQTFIGD SEEYQARCRA CHGKKKK 187
Length:187
Mass (Da):21,169
Last modified:July 28, 2009 - v1
Checksum:iD8EF5FB4160361DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM864216 Genomic DNA. Translation: CAT05387.1.
RefSeqiWP_012751880.1. NC_012806.1.
YP_002961190.1. NC_012806.1.

Genome annotation databases

EnsemblBacteriaiCAT05387; CAT05387; MCJ_007010.
GeneIDi7989662.
KEGGimco:MCJ_007010.
PATRICi20007599. VBIMycCon56923_0662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM864216 Genomic DNA. Translation: CAT05387.1 .
RefSeqi WP_012751880.1. NC_012806.1.
YP_002961190.1. NC_012806.1.

3D structure databases

ProteinModelPortali C5J7C4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 45361.MCJ_007010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAT05387 ; CAT05387 ; MCJ_007010 .
GeneIDi 7989662.
KEGGi mco:MCJ_007010.
PATRICi 20007599. VBIMycCon56923_0662.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.
OMAi DHISEST.
OrthoDBi EOG69D3J2.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Mycoplasma conjunctivae genome sequencing, annotation and analysis."
    Calderon-Copete S.P., Wigger G., Wunderlin C., Schmidheini T., Frey J., Quail M.A., Falquet L.
    BMC Bioinformatics 10:S7-S7(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25834 / HRC/581 / NCTC 10147.

Entry informationi

Entry nameiC5J7C4_MYCCR
AccessioniPrimary (citable) accession number: C5J7C4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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