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C5J7C4

- C5J7C4_MYCCR

UniProt

C5J7C4 - C5J7C4_MYCCR

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Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma conjunctivae (strain ATCC 25834 / HRC/581 / NCTC 10147)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptorUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi149 – 1491ZincUniRule annotation
Metal bindingi178 – 1781ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation
Nucleotide bindingi89 – 924ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:MCJ_007010Imported
OrganismiMycoplasma conjunctivae (strain ATCC 25834 / HRC/581 / NCTC 10147)Imported
Taxonomic identifieri572263 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001491: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi45361.MCJ_007010.

Structurei

3D structure databases

ProteinModelPortaliC5J7C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiDHISEST.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5J7C4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKKFFEGII EVITGPMFSG KSDELIKRVR TLSYANINTL VVKPKIDDRW
60 70 80 90 100
TTHEIVSRSG ARIPTFNVQD TQEIKALFEQ GDYQAIAVDE IQFFENEIIK
110 120 130 140 150
YLDDLANKGI RVIASGLDQD YARNPFGPLP QLMALAESVT KLQAICNICK
160 170 180
RAATTSARII NSKEQTFIGD SEEYQARCRA CHGKKKK
Length:187
Mass (Da):21,169
Last modified:July 28, 2009 - v1
Checksum:iD8EF5FB4160361DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM864216 Genomic DNA. Translation: CAT05387.1.
RefSeqiWP_012751880.1. NC_012806.1.
YP_002961190.1. NC_012806.1.

Genome annotation databases

EnsemblBacteriaiCAT05387; CAT05387; MCJ_007010.
GeneIDi7989662.
KEGGimco:MCJ_007010.
PATRICi20007599. VBIMycCon56923_0662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM864216 Genomic DNA. Translation: CAT05387.1 .
RefSeqi WP_012751880.1. NC_012806.1.
YP_002961190.1. NC_012806.1.

3D structure databases

ProteinModelPortali C5J7C4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 45361.MCJ_007010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAT05387 ; CAT05387 ; MCJ_007010 .
GeneIDi 7989662.
KEGGi mco:MCJ_007010.
PATRICi 20007599. VBIMycCon56923_0662.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.
OMAi DHISEST.
OrthoDBi EOG69D3J2.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Mycoplasma conjunctivae genome sequencing, annotation and analysis."
    Calderon-Copete S.P., Wigger G., Wunderlin C., Schmidheini T., Frey J., Quail M.A., Falquet L.
    BMC Bioinformatics 10:S7-S7(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25834 / HRC/581 / NCTC 10147Imported.

Entry informationi

Entry nameiC5J7C4_MYCCR
AccessioniPrimary (citable) accession number: C5J7C4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3