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C5J7C4

- C5J7C4_MYCCR

UniProt

C5J7C4 - C5J7C4_MYCCR

Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma conjunctivae (strain ATCC 25834 / HRC/581 / NCTC 10147)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei90 – 901Proton acceptorUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi149 – 1491ZincUniRule annotation
    Metal bindingi178 – 1781ZincUniRule annotation
    Metal bindingi181 – 1811ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228ATPUniRule annotation
    Nucleotide bindingi89 – 924ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:MCJ_007010Imported
    OrganismiMycoplasma conjunctivae (strain ATCC 25834 / HRC/581 / NCTC 10147)Imported
    Taxonomic identifieri572263 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001491: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi45361.MCJ_007010.

    Structurei

    3D structure databases

    ProteinModelPortaliC5J7C4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiDHISEST.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5J7C4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYKKFFEGII EVITGPMFSG KSDELIKRVR TLSYANINTL VVKPKIDDRW    50
    TTHEIVSRSG ARIPTFNVQD TQEIKALFEQ GDYQAIAVDE IQFFENEIIK 100
    YLDDLANKGI RVIASGLDQD YARNPFGPLP QLMALAESVT KLQAICNICK 150
    RAATTSARII NSKEQTFIGD SEEYQARCRA CHGKKKK 187
    Length:187
    Mass (Da):21,169
    Last modified:July 28, 2009 - v1
    Checksum:iD8EF5FB4160361DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM864216 Genomic DNA. Translation: CAT05387.1.
    RefSeqiWP_012751880.1. NC_012806.1.
    YP_002961190.1. NC_012806.1.

    Genome annotation databases

    EnsemblBacteriaiCAT05387; CAT05387; MCJ_007010.
    GeneIDi7989662.
    KEGGimco:MCJ_007010.
    PATRICi20007599. VBIMycCon56923_0662.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM864216 Genomic DNA. Translation: CAT05387.1 .
    RefSeqi WP_012751880.1. NC_012806.1.
    YP_002961190.1. NC_012806.1.

    3D structure databases

    ProteinModelPortali C5J7C4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 45361.MCJ_007010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAT05387 ; CAT05387 ; MCJ_007010 .
    GeneIDi 7989662.
    KEGGi mco:MCJ_007010.
    PATRICi 20007599. VBIMycCon56923_0662.

    Phylogenomic databases

    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi DHISEST.
    OrthoDBi EOG69D3J2.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Mycoplasma conjunctivae genome sequencing, annotation and analysis."
      Calderon-Copete S.P., Wigger G., Wunderlin C., Schmidheini T., Frey J., Quail M.A., Falquet L.
      BMC Bioinformatics 10:S7-S7(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25834 / HRC/581 / NCTC 10147Imported.

    Entry informationi

    Entry nameiC5J7C4_MYCCR
    AccessioniPrimary (citable) accession number: C5J7C4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3